Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Where Does N-Formylmethionine Come from? What for? Where Is It Going? What is the origin of N-formylmethionine in eukaryotic cells?

  • Lee, Chang-Seok (Department of Life Sciences, Pohang University of Science and Technology) ;
  • Kim, Dasom (Department of Life Sciences, Pohang University of Science and Technology) ;
  • Hwang, Cheol-Sang (Department of Life Sciences, Pohang University of Science and Technology)
  • Received : 2021.12.07
  • Accepted : 2021.12.20
  • Published : 2022.03.31
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Abstract

Keywords

Acknowledgement

We thank all the members of the Hwang laboratories for their discussions and comments. We also thank Edanz (https://www.edanz.com/ac) for editing a draft of this manuscript. This work was supported by grants from the Korean Government (MSIP) NRF-2020R1A3B2078127 and NRF-2017R1A5A1015366 (C.-S.H.), and the BK21 Plus program (C.-S.H.).

References

  1. Adams, J.M. and Capecchi, M.R. (1966). N-formylmethionyl-sRNA as the initiator of protein synthesis. Proc. Natl. Acad. Sci. U. S. A. 55, 147-155. https://doi.org/10.1073/pnas.55.1.147
  2. Cai, N., Gomez-Duran, A., Yonova-Doing, E., Kundu, K., Burgess, A., Golder, Z., Calabrese, C., Bonder, M., Camacho, M., Lawson, R., et al. (2021). Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases. Nat. Med. 27, 1564-1575. https://doi.org/10.1038/s41591-021-01441-3
  3. Chinnery, P.F., Elliott, H.R., Syed, A., Rothwell, P.M., and Oxford Vascular Study (2010). Mitochondrial DNA haplogroups and risk of transient ischaemic attack and ischaemic stroke: a genetic association study. Lancet Neurol. 9, 498-503. https://doi.org/10.1016/S1474-4422(10)70083-1
  4. Dickerman, H.W., Steers, E., Jr., Redfield, B.G., and Weissbach, H. (1967). Methionyl soluble ribonucleic acid transformylase. I. Purification and partial characterization. J. Biol. Chem. 242, 1522-1525. https://doi.org/10.1016/S0021-9258(18)96123-5
  5. Housman, D., Jacobs-Lorena, M., Rajbhandary, U.L., and Lodish, H.F. (1970). Initiation of haemoglobin synthesis by methionyl-tRNA. Nature 227, 913-918. https://doi.org/10.1038/227913a0
  6. Hudson, G., Nalls, M., Evans, J., Breen, D., Winder-Rhodes, S., Morrison, K., Morris, H., Williams-Gray, C., Barker, R., Singleton, A., et al. (2013). Two-stage association study and meta-analysis of mitochondrial DNA variants in Parkinson's disease. Neurology 80, 2042-2048. https://doi.org/10.1212/WNL.0b013e318294b434
  7. Kim, J., Seok, O., Ju, S., Heo, J., Yeom, J., Kim, D., Yoo, J., Varshavsky, A., Lee, C., and Hwang, C. (2018). Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway. Science 362, eaat0174. https://doi.org/10.1126/science.aat0174
  8. Kummer, E. and Ban, N. (2021). Mechanisms and regulation of protein synthesis in mitochondria. Nat. Rev. Mol. Cell Biol. 22, 307-325. https://doi.org/10.1038/s41580-021-00332-2
  9. Marcker, K. and Sanger, F. (1964). N-formyl-methionyl-S-RNA. J. Mol. Biol. 8, 835-840. https://doi.org/10.1016/s0022-2836(64)80164-9
  10. Raoof, M., Zhang, Q., Itagaki, K., and Hauser, C. (2010). Mitochondrial peptides are potent immune activators that activate human neutrophils via FPR-1. J. Trauma 68, 1328-1334. https://doi.org/10.1097/TA.0b013e3181dcd28d
  11. Smith, A.E. and Marcker, K.A. (1968). N-formylmethionyl transfer RNA in mitochondria from yeast and rat liver. J. Mol. Biol. 38, 241-243. https://doi.org/10.1016/0022-2836(68)90409-9
  12. Waller, J.P. (1963). The NH2-terminal residues of the proteins from cell-free extracts of E. coli. J. Mol. Biol. 7, 483-496. https://doi.org/10.1016/s0022-2836(63)80096-0
  13. Zhang, G., Wang, X., Rothermel, B., Lavandero, S., and Wang, Z. (2021). The integrated stress response in ischemic diseases. Cell Death Differ. 2021 Nov 6 [Epub]. https://doi.org/10.1038/s41418-021-00889-7