한국동물위생학회지 (Korean Journal of Veterinary Service)

  • 제45권1호
  • /
  • Pages.55-61
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  • 2022
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  • 3022-7372(pISSN)
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  • 2287-7630(eISSN)
한국동물위생학회 (The Korean Society of Veterinary Service)
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Assessment of coagulation function by thromboelastography in dogs with mitral valve insufficiency

  • Jeong, Chorok (College of Veterinary Medicine, Jeonbuk National University) ;
  • Seo, Minwoong (College of Veterinary Medicine, Jeonbuk National University) ;
  • Chang, Ocki (College of Veterinary Medicine, Jeonbuk National University) ;
  • Park, Jinho (College of Veterinary Medicine, Jeonbuk National University) ;
  • Park, Chul (College of Veterinary Medicine, Jeonbuk National University)
  • 투고 : 2022.01.27
  • 심사 : 2022.03.23
  • 발행 : 2022.03.30
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초록

In veterinary medicine, a variety of disease are known to cause coagulation abnormalities. Identification of these coagulation abnormalities have been relied on traditional coagulation assays(platelet concentration, aPTT, PT, D-dimer, fibrinogen) which take only a small part of the coagulation pathways rather than global hemostatic capacity. Among of the hypercoagulable diseases, cardiovascular disease, such as mitral valvular disease, was not regarded as the cause of the hypercoagulability. The value of a thromboelastography (TEG) as an early predictor of coagulopathy, especially hypercoagulability, has been founded. It was associated with decreased R and K values, and increased MA and α angle. The objective of this study was to compare thromboelastography results and those of traditional coagulation tests between twenty adult dogs with mitral insufficiency (MVI group) and eleven adult healthy dogs (Healthy group). As a results, MA values in the patients with mitral insufficiency (68.8±7.8 mm) were significantly higher than the normal patients (60.4±4.8 mm) (P value<0.05). Although a little report has been reported in veterinary medicine, platelet activation seems to be related with hypercoagulability in MVI patients in human medicine. The result of this report can support this pathophysiology in veterinary medicine. In addition to traditional coagulation assay, global assessment of coagulopathy using TEG, especially ability to detect hypercoagulability, may be useful for customized treatment in MVI patients. To achieve this, further study is needed to define pathophysiology and effect of medication.

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과제정보

This study was supported by Agriculture, Food and Rural Affairs Convergence Technologies Program for Educating Creative Global Leader.

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