Childhood Kidney Diseases

Korean Society of Pediatric Nephrology (대한소아신장학회)
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Newly diagnosed pediatric immunoglobulin A nephropathy after vaccination against SARS-CoV-2: a case report

  • Do Young, Kim (Department of Pediatrics, Korea University Ansan Hospital) ;
  • Hyung Eun, Yim (Department of Pediatrics, Korea University Ansan Hospital) ;
  • Min Hwa, Son (Department of Pediatrics, Korea University Ansan Hospital) ;
  • Kee Hwan, Yoo (Department of Pediatrics, Korea University Guro Hospital)
  • Received : 2022.09.08
  • Accepted : 2022.10.31
  • Published : 2022.12.31
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Abstract

The messenger RNA-based vaccine for the coronavirus disease 2019 (COVID-19) may induce glomerulonephritis, including immunoglobulin A nephropathy (IgAN). New-onset IgAN triggered by vaccination against COVID-19 has been reported rarely, especially in children. Herein, we report a pediatric case of newly diagnosed IgAN after administration of the Pfizer vaccine for COVID-19. A 12-year-old girl was referred to our hospital for evaluation of gross hematuria after inoculation with the second dose of Pfizer's COVID-19 vaccine; she had no adverse effects after the first dose. At the time of admission, she showed heavy proteinuria and persistent hematuria. Kidney biopsy revealed an IgAN, and she was treated with an oral steroid and an angiotensin-converting enzyme inhibitor. Four months after discharge, the proteinuria and hematuria resolved completely.

Keywords

Acknowledgement

We would like to express our gratitude to Professor Bo-Kyung Je (Department of Radiology, Korea University Ansan Hospital, Korea University College of Medicine) for performing the kidney biopsy.

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