Journal of Dental Anesthesia and Pain Medicine

  • 제22권2호
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  • Pages.97-105
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  • 2022
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  • 2383-9309(pISSN)
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  • 2383-9317(eISSN)
대한치과마취과학회 (The Korean Dental Society of Anesthsiology)
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The anti-nociceptive effect of BPC-157 on the incisional pain model in rats

  • Jung, Young-Hoon (Department of Anesthesia and Pain Medicine, Pusan National University Hospital) ;
  • Kim, Haekyu (Department of Anesthesia and Pain Medicine, Pusan National University Hospital) ;
  • Kim, Hyaejin (Department of Anesthesia and Pain Medicine, Pusan National University Hospital) ;
  • Kim, Eunsoo (Department of Anesthesia and Pain Medicine, Pusan National University Hospital) ;
  • Baik, Jiseok (Department of Anesthesia and Pain Medicine, Pusan National University Hospital) ;
  • Kang, Hyunjong (Department of Anesthesia and Pain Medicine, Pusan National University Hospital)
  • 투고 : 2022.01.05
  • 심사 : 2022.01.24
  • 발행 : 2022.04.01
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초록

Background: The pentadecapeptide BPC-157 has been shown to have anti-inflammatory and wound healing effects on multiple target tissues and organs. Peptides have potent anti-inflammatory effects on periodontal tissues in rats with periodontitis. Few studies have investigated the effect of BPC-157 on pain after dental procedures or oral surgeries. The purpose of the present study was to investigate the antinociceptive effects of BPC-157 on postoperative incisional pain in rats. Methods: Sprague-Dawley rats were randomly divided into five groups: control (saline with the same volume), BPC10 (10 ㎍/kg of BPC-157), BPC20 (20 ㎍/kg of BPC-157), BPC40 (40 ㎍/kg of BPC-157), and morphine (5 mg/kg of morphine). A 1-cm longitudinal incision was made through the skin, fascia, and muscle of the plantar aspect of the hind paw in isoflurane-anesthetised rats. Withdrawal responses were measured using von Frey filaments at 0, 2, 6 h and 4, 7 d after incision. The formalin test was also performed to differentiate its anti-nociceptive effect from an inflammatory reaction or central sensitization. Pain behavior was quantified periodically in phases 1 and 2 by counting the number of flinches in the ipsilateral paw after injection with 30 µL of 5% formalin. Results: The threshold of mechanical allodynia was significantly increased in the BPC10, BPC20, BPC40 and morphine groups compared with that in the control group at 2 h. These increasing thresholds then returned to the levels of the control group. The BPC-157 group showed a much higher threshold at 4 days after incision than the control group. The thresholds of the BPC groups, except the morphine group, were normalized 7 days after incision. The flinching numbers of the BPC10, BPC20, BPC40 and morphine groups were significantly decreased in phase 1, but there was no decrease in the BPC-157 groups except the morphine group in phase 2. Conclusions: BPC-157 was effective only for a short period after incision. It was also effective during phase 1 but not during phase 2, as determined by the formalin test. BPC-157 might have a short antinociceptive effect, even though it has anti-inflammatory and wound healing effects.

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과제정보

The authors declare no conflict of interest relevant to this article. The study was funded by the Basic Research Support Project of Pusan National University.

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