Journal of the Korea Convergence Society (한국융합학회논문지)

Korea Convergence Society (한국융합학회)
권호 표지
DOI QR코드

DOI QR Code

Risk Factors for Depression, Anxiety, and Stress in Patients with Polycystic Ovary Syndrome

다낭난소증후군 환자에서의 우울, 불안, 스트레스를 유발하는 위험 인자

  • Park, Joon Cheol (Department of Obstetrics and Gynecology, Keimyung University School of Medicine)
  • 박준철 (계명대학교 의과대학 산부인과)
  • Received : 2022.02.10
  • Accepted : 2022.03.20
  • Published : 2022.03.28
Download PDF
⟨ Previous Next ⟩

Abstract

The aim of this study was to evaluate anxiety, depression and stress in women with polycystic ovary syndrome(PCOS) and to investigate the risk factors related to psychological difficulties. Sixty women with PCOS were evaluated for level of psychological stress using Beck depression inventory(BDI) and Depression anxiety stress scale(DASS) questionnaire. Serum antimullerian hormone, total testosterone, lutenizing hormone, follicle stimulating hormone, estradiol, lipid profile and 75g oral glucose tolerance test were measured. Thirty healthy women served as the control. Fifty two women with PCOS and 29 healthy women completed a questionnaire. Women with depression who scored >13 by BDI and >10 by DASS were 38.5 %, women with anxiety who scored >8 by DASS were 23.1 %, and women with stress who scored >15 by DASS were 30.8 %, which were significantly higher than control. In PCOS women, total testosterone, LH and AMH were significantly correlated with depression and stress. Weight, body mass index and waist-hip ratio were also significantly correlated with depression. In women diagnosed as diabetes and hyperlipidemia, depression and stress were significantly prevalent. Women with PCOS seemed to be more vulnerable to depression, anxiety and stress. Early diagnosis and management should be considered.

본 연구는 다낭난소증후군 여성의 불안, 우울, 스트레스를 평가하고, 발병 위험인자에 대하여 살펴보고자, 다낭난소증후군 여성을 대상으로 Beck's 우울증(BDI) 및 우울 불안 스트레스 척도(DASS) 설문을 시행하였고, 항뮐러리안호르몬(AMH), 총 테스토스테론, 황체형성호르몬(LH), 난포자극호르몬(FSH), 에스트라디올(E2), 지질대사검사 및 당부하검사(OGTT)를 시행 후 분석하였다. 설문지를 완전히 작성하여 회수된 52명의 환자군과 29명의 건강한 가임기 여성 대조군을 분석하였다. 다낭난소증후군 환자 중 BDI>13점, DASS>10점인 우울증 38.5 %, DASS>8점인 불안 23.1 %, DASS>15점인 스트레스 30.8 %로 대조군에 비해 유의하게 높았다. 총 테스토스테론, LH 및 AMH는 우울증 및 스트레스와 유의한 상관관계를 보였고, 체중 및 체질량지수도 우울증과 유의한 상관관계를 보였다. 당뇨병과 고지혈증으로 진단된 여성에서 우울증과 스트레스가 높았다. 다낭난소증후군 여성은 우울증, 불안 및 스트레스에 더 취약한 것으로 나타나, 조기진단과 치료가 중요하다.

Keywords

References

  1. N. Raja-Khan et al. (2015). Mindfulness-based stress reduction for overweight/obese women with and without polycystic ovary syndrome: design and methods of a pilot randomized controlled trial, Contemp Clin Trials, 41, 287-297. DOI : 10.1016/j.cct.2015.01.021
  2. S. Benson et al. (2009). Disturbed stress responses in women with polycystic ovary syndrome, Psychoneuroendocrinology, 34(5), 727-735. DOI : 10.1016/j.psyneuen.2008.12.001
  3. C. Brady, S. S. Mousa & S. A. Mousa. (2009). Polycystic ovary syndrome and its impact on women's quality of life: More than just an endocrine disorder, Drug Healthc Patient Saf, 1, 9-15. DOI : 10.2147/dhps.s4388
  4. S. Alur-Gupta, I. Lee, A. Chemerinski, C. Liu, J. Lipson, K. Allison et al. (2021). Racial differences in anxiety, depression, and quality of life in women with polycystic ovary syndrome, F S Rep, 2(2), 230-237. DOI : 10.1016/j.xfre.2021.03.003
  5. S. Y. Lim et al. (2011). The validation study of Beck depression scale 2 in Korean women, Anxiety and Mood, 7(1), 48-53.
  6. D. Jun, V. Johnston, J. M. Kim, S. O'Leary. (2018). Cross-cultural adaptation and validation of the Depression, Anxiety and Stress Scale-21 (DASS-21) in the Korean working population. Work, 59(1), 93-102. DOI : 10.3233/WOR-172661
  7. H. Teede, A. Deeks & L. Moran. (2010). Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med, 8, 41. DOI : 10.1186/1741-7015-8-41
  8. V. Kumarapeli, R. A. Seneviratne & C. Wijeyaratne. (2011). Health-related quality of life and psychological distress in polycystic ovary syndrome: a hidden facet in South Asian women, BJOG, 118(3), 319-328. DOI : 10.1111/j.1471-0528.2010.02799.x
  9. F. Z. Zangeneh, M. Jafarabadi, M. M. Naghizadeh, N. Abedinia & F. Haghollahi. (2012). Psychological distress in women with polycystic ovary syndrome from imam khomeini hospital, tehran, J Reprod Infertil, 13(2), 111-115.
  10. F. Bazarganipour, S. Ziaei, A. Montazeri, F. Foroozanfard, A. Kazemnejad & S. Faghihzadeh. (2013). Psychological investigation in patients with polycystic ovary syndrome, Health Qual Life Outcomes, 11, 141. DOI: 10.1186/1477-7525-11-141
  11. A. Dokras, S. Clifton, W. Futterweit & R. Wild. (2011). Increased risk for abnormal depression scores in women with polycystic ovary syndrome: a systematic review and meta-analysis, Obstet Gynecol, 117(1), 145-152. DOI : 10.1097/AOG.0b013e318202b0a4
  12. A. Dokras, S. Clifton, W. Futterweit & R. Wild. (2012). Increased prevalence of anxiety symptoms in women with polycystic ovary syndrome: systematic review and meta-analysis, Fertil Steril, 97(1), 225-230. DOI : 10.1016/j.fertnstert.2011.10.022
  13. M. B. Khomami, F. R. Tehrani, S. Hashemi, M. Farahmand & F. Azizi. (2015). Of PCOS symptoms, hirsutism has the most significant impact on the quality of life of Iranian women, PLoS One, 10(4), e0123608. DOI : 10.1371/journal.pone.0123608
  14. I. S. Rodino, S. Byrne & K. A. Sanders. (2016). Obesity and psychological wellbeing in patients undergoing fertility treatment, Reprod Biomed Online, 32(1), 104-112. DOI : 10.1016/j.rbmo.2015.10.002
  15. J. Guidi et al. (2015). Psychological aspects of hyperandrogenic states in late adolescent and young women, Clin Endocrinol (Oxf), 83(6), 872-878. DOI : 10.1111/cen.12783
  16. A. Keegan, L. M. Liao & M. Boyle. (2003). Hirsutism: a psychological analysis, J Health Psychol, 8(3), 327-345. DOI : 10.1177/13591053030083004
  17. K. M. Carpenter, D. S. Hasin, D. B. Allison & M. S. Faith. (2009). Relationships between obesity and DSM-IV major depressive disorder, suicide ideation, and suicide attempts: results from a general population study, Am J Public Health, 90(2), 251-257. DOI : 10.2105/ajph.90.2.251
  18. M. J. Kwon, Y. S. Song, & S. A. Kim. (2021). Influencing factors of depression in adults according to the cause of stress, J Korea Convergence Society, 12(12), 453-465. https://doi.org/10.15207/JKCS.2021.12.12.453
  19. J. Schmid, S. Kirchengast, E. Vytiska-Binstorfer & J. Huber. (2004). Infertility caused by PCOS--health-related quality of life among Austrian and Moslem immigrant women in Austria, Hum Reprod, 19(10), 2251-2257. DOI: 10.1093/humrep/deh432
  20. D. Dowdy. (2012). Emotional needs of teens with polycystic ovary syndrome, J Pediatr Nurs, 27(1), 55-64. DOI : 10.1016/j.pedn.2010.08.001
  21. L. Kolahi, N. Asemi, M. Mirzaei, N. Adibi, M. Beiraghdar & A. M. Mehret. (2015). The relationship between quality of life and coping strategies in polycystic ovary syndrome patients, Adv Biomed Res, 4, 168. DOI : 10.4103/2277-9175.162545
  22. S. Hahn et al. (2006). Metformin treatment of polycystic ovary syndrome improves health-related quality-of-life, emotional distress and sexuality, Hum Reprod, 21(7), 1925-1934. DOI : 10.1093/humrep/del069
  23. N. Cinar, A. Harmanci, B. Demir & B. O. Yildiz. (2012). Effect of an oral contraceptive on emotional distress, anxiety and depression of women with polycystic ovary syndrome: a prospective study, Hum Reprod, 27(6), 1840-1845. DOI : 10.1093/humrep/des113
  24. C. Stefanaki et al. (2015). Impact of a mindfulness stress management program on stress, anxiety, depression and quality of life in women with polycystic ovary syndrome: a randomized controlled trial, Stress, 18(1), 57-66. DOI : 10.3109/10253890.2014.974030
  25. M. Mansson, J. Holte, K. Landin-Wilhelmsen, E. Dahlgren, A. Johansson, M. Landen. (2008). Women with polycystic ovary syndrome are often depressed or anxious - a case control study, Psychoneuroendocrinology, 33(8), 1132-1138. DOI : 10.1016/j.psyneuen.2008.06.003