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A Case of Asthma-Chronic Obstructive Pulmonary Disease Syndrome Exacerbated After COVID-19 Infection

코로나19 감염으로 악화된 천식-만성폐쇄성폐질환 중복증후군 환자 치험 1례

  • Mariah, Kim (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Hee-kyung, Kang (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • So-jung, Park (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • So-yeon, Kim (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Young-ju, Yun (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • In, Lee (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Chang-woo, Han (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Jin-woo, Hong (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Jung-nam, Kwon (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Jun-yong, Choi (Dept. of Korean Internal Medicine, Korean Medicine Hospital of Pusan National University)
  • 김마리아 (부산대학교 한방병원 한방내과) ;
  • 강희경 (부산대학교 한방병원 한방내과) ;
  • 박소정 (부산대학교 한방병원 한방내과) ;
  • 김소연 (부산대학교 한방병원 한방내과) ;
  • 윤영주 (부산대학교 한방병원 한방내과) ;
  • 이인 (부산대학교 한방병원 한방내과) ;
  • 한창우 (부산대학교 한방병원 한방내과) ;
  • 홍진우 (부산대학교 한방병원 한방내과) ;
  • 권정남 (부산대학교 한방병원 한방내과) ;
  • 최준용 (부산대학교 한방병원 한방내과)
  • Received : 2022.11.03
  • Accepted : 2022.12.27
  • Published : 2022.12.30

Abstract

Background: We present a case of asthma-chronic obstructive pulmonary disease syndrome (ACOS), which has features of both asthma and chronic obstructive pulmonary disease, in a 63-year-old man treated with Korean medicine. Methods: For four weeks of hospitalization, the patient received acupuncture, Guarujisil-tang decoction, and herbal steam therapy. The main symptoms of ACOS, which are dyspnea, chest discomfort, and throat discomfort, were treated with acupuncture. Guarujisil-tang decoction and herbal steam therapy were administered to relieve cough and smooth the expectoration of mucus. Results: By the end of hospitalization, no significant change was observed in lung function. However, the patient's subjective symptoms, including dyspnea, chest discomfort, sore throat, and sweating, were improved. The patient's objective sign of opaque yellow mucus changed to clear mucus after the treatment. His scores for the quality of life questionnaire for adult Korean asthmatics and the modified Borg scale also showed improvement from 42 to 62 and from 3 to 1, respectively. Conclusions: Although we reported only one ACOS case, this study is significant in that case reports of ACOS treated with Korean medicine are rare. Further study is needed to confirm the effectiveness of Korean medicine in patients with ACOS.

Keywords

Acknowledgement

본 연구는 2021년도 부산대학교병원 임상연구비 지원으로 이루어졌음.

References

  1. Adeloye D, Chua S, Lee C, Basquill C, Papana A, Theodoratou E, et al. Global and regional estimates of COPD prevalence: Systematic review and meta-analysis. J Glob Health 2015;5(2):020415. 
  2. Soriano JB, Davis KJ, Coleman B, Visick G, Mannino D, Pride NB. The proportional Venn diagram of obstructive lung disease: two approximations from the United States and the United Kingdom. Chest 2003;124(2):474-81.  https://doi.org/10.1378/chest.124.2.474
  3. Bleecker ER. Similarities and differences in asthma and COPD. The Dutch hypothesis. Chest 2004;126(2 Suppl):93S-5S;discussion 159S-61S. 
  4. Sin DD. Asthma-COPD Overlap Syndrome: What We Know and What We Don't. Tuberculosis and Respiratory Diseases 2017;80(1):11-20.  https://doi.org/10.4046/trd.2017.80.1.11
  5. Department of Pulmonary System of Nationwide College of Korean Medicine. Internal Medicine of Pulmonary System. Seoul: Nado; 2019. 
  6. Shergis JL, Wu L, Zhang AL, Guo X, Lu C, Xue CC. Herbal medicine for adults with asthma: A systematic review. J Asthma 2016;53(6):650-9.  https://doi.org/10.3109/02770903.2015.1101473
  7. Kwon CY, Lee B, Lee BJ, Kim KI, Jung HJ. Herbal Medicine Compared to Placebo for Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis. Front Pharmacol 2021;12:717570. 
  8. Park JW, Cho YS, Lee SY, Nahm DH, Kim YK, Kim DK, et al. Multi-center study for the utilization of quality of life questionnaire for adult Korean asthmatics (QLQAKA). Korean J Asthma Allergy Clin Immunol 2000;20(3):467-79. 
  9. Kendrick KR, Baxi SC, Smith RM. Usefulness of the modified 0-10 Borg scale in assessing the degree of dyspnea in patients with COPD and asthma. J Emerg Nurs 2000;26(3):216-22.  https://doi.org/10.1016/S0099-1767(00)90093-X
  10. Dirkje SP, Klaus FR, The Asthma-COPD overlap syndrome. N Engl J Med 2015;373:1241-9.  https://doi.org/10.1056/NEJMra1411863
  11. Bujarski S, Parulekar AD, Sharafkhaneh A, Hanania NA. The Asthma COPD Overlap Syndrome (ACOS). Curr Allergy Asthma Rep 2015;15(7):1-9.  https://doi.org/10.1007/s11882-014-0501-1
  12. Kim HK, Lee SD. Pathophysiology of Chronic Obstructive Pulmonary Disease. Tuberculosis and Respiratory Diseases 2005;59(1):5-13.  https://doi.org/10.4046/trd.2005.59.1.5
  13. Leung JM, Sin DD. Asthma-COPD overlap syndrome: pathogenesis, clinical features, and therapeutic targets. BMJ 2017;358:j3772. 
  14. Louie S, Zeki AA, Schivo M, Chan AL, Yoneda KY, Avdalovic M, et al. The asthma-chronic obstructive pulmonary disease overlap syndrome: pharmacotherapeutic considerations. Expert Rev Clin Pharmacol 2013;6(2):197-219.  https://doi.org/10.1586/ecp.13.2
  15. 黃度淵. 方藥合編. 서울: 南山堂; 1978, p. 287-8. 
  16. Lee MW, Park DI. The clinical study of Gualouzhishiltang on chronic respiratory disease due to smoking. Korean J Orient Int Med 1998;19(1):343-52. 
  17. Park JJ, Kim YS, Seol IC. Effect of Jawan-Chihyosan and Gwaru-Jisiltang on Secretion of Mucin by the First Cultivated Goblet Cells of Rodent's Airway. Korean J Oriental Physiology & Pathology 2006;20(1):69-75. 
  18. Lee JE, Park YC. Effects of CheongGeumGangHwa-Tang(CGGH), GwaRuJiSil-Tang(GRJS) on mucin secretion from airway goblet cells. Korean J Orient Int Med 2004;25(2):238-44. 
  19. Nurwati I, Muthmainah M, Huda KN. Acupuncture for Asthma:Its Potential Significance in Clinical Practice. Medical Acupuncture 2020;32(5):272-9.  https://doi.org/10.1089/acu.2020.1443
  20. Choi JY, Jung HJ, Kim JI, Lee MS, Kang KW, Roh YL, et al. A randomized pilot study of acupuncture as an adjunct therapy in adult asthmatic patients. J Asthma 2010;47(7):774-80. https://doi.org/10.3109/02770903.2010.485665