한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제50권4호
  • /
  • Pages.533-547
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  • 2022
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  • 1598-642X(pISSN)
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  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
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Hair Growth Effect of TS-SCLF from Schisandra chinensis Extract Fermented with Lactobacillus plantarum

  • Young Min, Woo (Department of Pharmaceutical Engineering, College of Medical and Life Science, Silla University) ;
  • Jae Yong, Seo (Creative Innovation Research Center, Cosmecca Korea, Co., Ltd.) ;
  • Soo-ya, Kim (Department of Pharmaceutical Engineering, College of Medical and Life Science, Silla University) ;
  • Ji Hyun, Cha (Department of Pharmaceutical Engineering, College of Medical and Life Science, Silla University) ;
  • Hyun Dae, Cho (Creative Innovation Research Center, Cosmecca Korea, Co., Ltd.) ;
  • Young Kwon, Cha (Creative Innovation Research Center, Cosmecca Korea, Co., Ltd.) ;
  • Ju Tae, Jeong (Creative Innovation Research Center, Cosmecca Korea, Co., Ltd.) ;
  • Sung Min, Park (Bio Convergence R&D Center, CoseedBioPharm, Co., Ltd.) ;
  • Hwa Sun, Ryu (Bio Convergence R&D Center, CoseedBioPharm, Co., Ltd.) ;
  • Jae Mun, Kim (Bio Convergence R&D Center, CoseedBioPharm, Co., Ltd.) ;
  • Moon Hoy, Kim (Bio Convergence R&D Center, CoseedBioPharm, Co., Ltd.) ;
  • Hee-Taek, Kim (Department of Korean Medical Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Semyung University) ;
  • Yong-Min, Kim (Department of Cosmetic Sciences and Beauty Biotechnology, Semyung University) ;
  • Kwang Sik, Joo (R&D Center, TS Trillion, Co., Ltd.) ;
  • Sun Mi, Lee (R&D Center, TS Trillion, Co., Ltd.) ;
  • JungNo, Lee (Bio Convergence R&D Center, CoseedBioPharm, Co., Ltd.) ;
  • Andre, Kim (Department of Pharmaceutical Engineering, College of Medical and Life Science, Silla University)
  • 투고 : 2022.06.29
  • 심사 : 2022.11.29
  • 발행 : 2022.12.28
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초록

This study investigated the hair growth effect of Schisandra chinensis extract (TS-SC) and TS-SC fermented by Lactobacillus plantarum (TS-SCLF) on human dermal papilla cells (hDPCs). The production of vascular endothelial growth factor (VEGF), insulin-like growth factor 1 (IGF-1), keratinocyte growth factor/fibroblast growth factor 7 (KGF/FGF-7) and hepatocyte growth factor (HGF), transforming growth factor beta 1 (TGF-β1) were examined. The secretion rates of VEGF and KGF/FGF-7 were high in TS-SC, and the secretion rates of IGF-1 and HGF were high in TS-SCLF. TGF-β1 was inhibited in a concentration-dependent manner in all samples. Gene expression of VEGF, IGF-1, KGF, HGF and alkaline phosphatase, relevant to hair growth, were examined. The data revealed that TS-SC and TS-SCLF successfully promoted hair growth in hDPCs. The IGF-1 gene was expressed in a dose-dependent manner in TS-SCLF. These results indicate that TS-SC and TS-SCLF fermented extract effectively promoted hair growth and gene expression relevant to hair growth in hDPCs. Used in clinical trials the test substance 'CMK-LPF01' showed a statistically significant increase in the number of hairs at 8 weeks, 16 weeks, and 24 weeks compared to before product use, and a change in hair growth, a secondary efficacy evaluation variable. Through additional research in the future, it is expected that "CMK-LPF01" can be developed as a functional material that can help alleviate symptoms of hair loss.

키워드

과제정보

This study was supported by the Technology Innovation Program (10077377, Development of hair and anti-aging cosmetic materials using lactic acid bacteria enzyme hydrolysates) funded By the Ministry of Trade, Industry & Energy (MOTIE, Korea) and supported by the Brain Busan 21+ project (BB21+).

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