한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제50권4호
  • /
  • Pages.457-464
  • /
  • 2022
  • /
  • 1598-642X(pISSN)
  • /
  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
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Monkeypox and Its Recent OUTBREAKS; A Systemic Review

  • Zain Ul, Abedien (Institute of Microbiology, University of Agriculture Faisalabad) ;
  • Kainat, Gul (Department of Microbiology, Abbottabad University of Science and Technology) ;
  • Maheen, Shafiq (Institute of Microbiology, University of Agriculture Faisalabad) ;
  • Khizar, Rahman (Institute of Microbiology, University of Agriculture Faisalabad)
  • 투고 : 2022.09.06
  • 심사 : 2022.10.31
  • 발행 : 2022.12.28
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초록

A public health concern emerging from a zoonotic disease. Monkeypox is caused by the orthopoxvirus specie Monkeypox virus (MPXV). Monkeypox was identified as the most common orthopoxvirus infection in humans following the eradication of smallpox. Monkeypox has a similar clinical presentation to smallpox. The MPXV is now considered a high-threat pathogen that causes a serious public-health problem. The continuous spread of Monkeypox virus from West Africa to all other places around the world throughout 2018 to 2022, have raised concerns that MPXV could have emerged to acquire the immunological and ecological niche vacated by smallpox virus. This review highlights the current knowledge about Monkeypox evolution, infection biology, and epidemiology around the world since from 1970 to 2022, with a focus on the human, viral, and cellular factors that influence virus emergence, infection, spread, and maintenance in nature. This paper also discusses the current therapeutic options for Monkeypox treatment and control. Under the right conditions, with limited smallpox vaccination and very little orthopoxvirus immunity in some areas of the world, MPXV could become a more efficient human pathogen. Finally, the review identified knowledge gaps, particularly in terms of identifying a definitive reservoir host for monkeypox and proposes future research endeavors to address the unanswered questions.

키워드

과제정보

The authors would like to express their deep appreciation and indebtedness to InstaMed Medical Equipment Trading LLC, UAE.

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