Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Monkeypox and Its Recent OUTBREAKS; A Systemic Review

  • Zain Ul, Abedien (Institute of Microbiology, University of Agriculture Faisalabad) ;
  • Kainat, Gul (Department of Microbiology, Abbottabad University of Science and Technology) ;
  • Maheen, Shafiq (Institute of Microbiology, University of Agriculture Faisalabad) ;
  • Khizar, Rahman (Institute of Microbiology, University of Agriculture Faisalabad)
  • Received : 2022.09.06
  • Accepted : 2022.10.31
  • Published : 2022.12.28
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Abstract

A public health concern emerging from a zoonotic disease. Monkeypox is caused by the orthopoxvirus specie Monkeypox virus (MPXV). Monkeypox was identified as the most common orthopoxvirus infection in humans following the eradication of smallpox. Monkeypox has a similar clinical presentation to smallpox. The MPXV is now considered a high-threat pathogen that causes a serious public-health problem. The continuous spread of Monkeypox virus from West Africa to all other places around the world throughout 2018 to 2022, have raised concerns that MPXV could have emerged to acquire the immunological and ecological niche vacated by smallpox virus. This review highlights the current knowledge about Monkeypox evolution, infection biology, and epidemiology around the world since from 1970 to 2022, with a focus on the human, viral, and cellular factors that influence virus emergence, infection, spread, and maintenance in nature. This paper also discusses the current therapeutic options for Monkeypox treatment and control. Under the right conditions, with limited smallpox vaccination and very little orthopoxvirus immunity in some areas of the world, MPXV could become a more efficient human pathogen. Finally, the review identified knowledge gaps, particularly in terms of identifying a definitive reservoir host for monkeypox and proposes future research endeavors to address the unanswered questions.

Keywords

Acknowledgement

The authors would like to express their deep appreciation and indebtedness to InstaMed Medical Equipment Trading LLC, UAE.

References

  1. Alakunle E, Moens U, Nchinda G, Okeke MI. 2020. Monkeypox virus in Nigeria: infection biology, epidemiology, and evolution. Viruses 12: 1257.
  2. Diven DG. 2001. An overview of poxviruses. J. Am. Acad. Dermatol. 44: 1-6. https://doi.org/10.1067/mjd.2001.109302
  3. Essbauer S, Pfeffer M, Meyer H. 2010. Zoonotic poxviruses. Vet. Microb. 140: 229-36. https://doi.org/10.1016/j.vetmic.2009.08.026
  4. (ICTV) ICoToV. Virus Taxonomy: 2020 Release. Available from: https://talk.ictvonline.org/taxonomy
  5. Jezek Z, Khodakevich LN, Wickett JF. 1987. Smallpox and its post-eradication surveillance. Bull. World Health Org. 65: 425.
  6. Monkeypox. Available online: https://www.who.int/health-topics/monkeypox/#tab=tab_1 (Accessed on 18 June 2022).
  7. Monkeypox Virus online. Available online: https://www.cdc.gov/poxvirus/monkeypox/clinicians/smallpox-vaccine.html (Accessed on 18 June 2022).
  8. Magnus PV, Andersen EK, Petersen KB, Birch-Andersen A. 1959. A pox-like disease in cynomolgus monkeys. Acta Pathol. Microbiol. Scandinavica 46: 156-176.
  9. Ladnyj ID, Ziegler P, Kima E. 1972. A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo. Bull. World Health Org. 46: 593.
  10. Albarnaz JD, Torres AA, Smith GL. 2018. Modulating vaccinia virus immunomodulators to improve immunological memory. Viruses 10: 101.
  11. Kugelman JR, Johnston SC, Mulembakani PM, Kisalu N, Lee MS, Koroleva G, et al. 2014. Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo. Emerg. Infect. Dis. 20: 232.
  12. Al-Mosawi DAJ. 2022. Human-monkey pox disease: An educational CME article. Int. J. Clin. Expl. Dermatol. 7: 33- 43.
  13. Tiwari D, Parikh T, Maram PD, Chauhan N, Kumar JS, Das A, et al. 2022. Monkeypox-a Review. Eur. J. Mol. Clin. Med. 9: 2599-2611.
  14. Weaver JR, Isaacs SN. 2008. Monkeypox virus and insights into its immunomodulatory proteins. Immunol. Rev. 225: 96-113. https://doi.org/10.1111/j.1600-065X.2008.00691.x
  15. Khodakevich L, Szczeniowski M, Jezek Z, Marennikova S, Nakano J, Meier F. 1987. Monkeypox virus in relation to the ecological features surrounding human settlements in Bumba zone, Zaire. Trop. Geogr. Med. 39: 56-63.
  16. Weinstein RA, Nalca A, Rimoin AW, Bavari S, Whitehouse CA. 2005. Reemergence of monkeypox: prevalence, diagnostics, and countermeasures. Clin. Infect. Dis. 41: 1765-1771. https://doi.org/10.1086/498155
  17. Kaler J, Hussain A, Flores G, Kheiri S, Desrosiers D. 2022. Monkeypox: a comprehensive review of transmission, pathogenesis, and manifestation. Cureus 14: e26531.
  18. Mucker EM, Shamblin JD, Goff AJ, Bell TM, Reed C, Twenhafel NA, et al. 2022. Evaluation of virulence in cynomolgus macaques using a virus preparation enriched for the extracellular form of monkeypox virus. Viruses 14: 1993.
  19. Hasan S, Saeed S. 2022. Monkeypox disease: An emerging public health concern in the shadow of COVID-19 pandemic: An update. Trop.Med. Infect. Dis. 7: 283.
  20. Ola P. 2022. Monkeypox deaths demand understanding of spectral theory of infectious disease pathogenesis.
  21. Fenner F, Henderson DA, Arita I, Jezek Z, Ladnyi ID. 1988. Smallpox and its eradication. Geneva: World Health Organization.
  22. Fenner F, Henderson DA, Arita I, Jezek Z, Ladnyi ID. 1988. Human monkeypox and other poxvirus infections of man. Smallpox and its Eradication. Geneva, Switzerland: World Health Organization. 1287-320.
  23. Kumar N, Acharya A, Gendelman HE, Byrareddy SN. 2022. The 2022 outbreak and the pathobiology of the monkeypox virus. J. Autoimm. 131: 102855.
  24. Lansiaux E, Jain N, Laivacuma S, Reinis A. 2022. The virology of human monkeypox virus (hMPXV): a brief overview. Virus Res. 322: 198932.
  25. Sah R, Abdelaal A, Reda A, Katamesh BE, Manirambona E, Abdelmonem H, et al. 2022. Monkeypox and its Possible Sexual Transmission: Where are we now with its evidence?. Pathogens 11: 924.
  26. Harvala H, Simmonds P. 2022. Evaluating the risk of transfusion and transplant-transmitted monkeypox infections. Transfus. Med. doi: 10.1111/tme.12918. Online ahead of print.
  27. Vivancos R, Anderson C, Blomquist P, Balasegaram S, Bell A, Bishop L, et al. 2022. Community transmission of monkeypox in the United Kingdom, April to May 2022. Eurosurveillance 27: 2200422.
  28. Diaz JH. 2021. The disease ecology, epidemiology, clinical manifestations, management, prevention, and control of increasing human infections with animal orthopoxviruses. Wilderness Environ. Med. 32: 528-536. https://doi.org/10.1016/j.wem.2021.08.003
  29. Goyal R, Devi M, Gautam RK, Gupta S. 2022. A comprehensive review on rising concern of transmission potential of monkeypox virus on healthcare system. Indo Global J. Pharm. Sci. 12: 265-272. https://doi.org/10.35652/IGJPS.2022.12035
  30. Hornuss D, Daehne T, Goetz V, Mueller M, Usadel S, Lorz A, et al. 2022. Transmission characteristics, replication patterns and clinical manifestations of human monkeypox virus-an in-depth analysis of four cases from Germany. Clin. Microbiol. Infect. doi: 10.1016/j.cmi.2022.09.012.
  31. Shepherd W, Beard PM, Brookes SM, Frost A, Roberts H, Russell K, Wyllie S. 2022. The risk of reverse zoonotic transmission to pet animals during the current global monkeypox outbreak, United Kingdom, June to mid-September 2022. Eurosurveillance 27: 2200758.
  32. Riopelle JC, Munster VJ, Port JR. 2022. Atypical and unique transmission of monkeypox virus during the 2022 outbreak: an overview of the current state of knowledge. Viruses 14: 2012.
  33. Presse C, Gustin V. 2022. Monkeypox: a zoonosis and sexually transmitted infection (STI) Press release of the French National Academy of Medicine.
  34. Miura F, Ewijk CEV, Backer JA, Xiridou M, Franz E, Couk EOd, et al. 2022. Estimated incubation period for monkeypox cases confirmed in the Netherlands, May 2022. Euro Surveill. 27: 2200448.
  35. Ihekweazu C, Yinka-Ogunleye A, Lule S, Ibrahim A. 2020. Importance of epidemiological research of monkeypox: is incidence increasing?. Expert Rev. Anti Infect. Ther. 18: 389-392. https://doi.org/10.1080/14787210.2020.1735361
  36. Beer EM, Rao VB. 2019. A systematic review of the epidemiology of human monkeypox outbreaks and implications for outbreak strategy. PLoS Negl. Trop. Dis. 13: e0007791.
  37. Fine PE, Jezek Z, Grab B, Dixon H. 1988. The transmission potential of monkeypox virus in human populations. Int. J. Epidemiol. 17: 643-650. https://doi.org/10.1093/ije/17.3.643
  38. Cho C, Wenner H. 1973. Monkeypox virus. Bacteriol. Rev. ASM. 37: 1-18. https://doi.org/10.1128/br.37.1.1-18.1973
  39. Kabuga AI, El Zowalaty ME. 2019. A review of the monkeypox virus and a recent outbreak of skin rash disease in Nigeria. J. Med. Virol. 91: 533-540. https://doi.org/10.1002/jmv.25348
  40. Fowotade A, Fasuyi TO, Bakare RA. 2018. Re-emergence of monkeypox in Nigeria: A cause for concern and public enlightenment. Afr. J. Clin. Exp. Microbiol. 19: 307-313. https://doi.org/10.4314/ajcem.v19i4.9
  41. Bunge EM, Hoet B, Chen L, Lienert F, Weidenthaler H, Baer LR, et al. 2022. The changing epidemiology of human monkeypox-A potential threat? A systematic review. PLoS Negl. Trop. Dis. 16: e0010141.
  42. Durski KN, McCollum AM, Nakazawa Y, Petersen BW, Reynolds MG, Briand S, et al. 2018. Emergence of monkeypox-west and central Africa, 1970-2017. MMWR Morb. Mortal. Wkly Rep. 67: 306-310. https://doi.org/10.15585/mmwr.mm6710a5
  43. Vaughan AM, Cenciarelli O, Colombe S, de Sousa LA, Fischer N, Gossner CM, et al. 2022. A large multi-country outbreak of monkeypox across 41 countries in the WHO European Region, 7 March to 23 August 2022. Eurosurveillance 27: 2200620.
  44. Chakraborty C, Bhattacharya M, Sharma AR, Dhama K. 2022. Evolution, epidemiology, geographical distribution, and mutational landscape of newly emerging monkeypox virus. GeroScience 12: 1-17.
  45. Li H, Zhang H, Ding K, Wang XH, Sun GY, Liu ZX, et al. 2022. The evolving epidemiology of monkeypox virus. Cytokine Growth Factor Rev. S1359-6101(22)00077-6.
  46. Vusirikala A, Charles H, Balasegaram S, Macdonald N, Kumar D, Barker-Burnside C, et al. 2022. Epidemiology of early monkeypox virus transmission in sexual networks of gay and bisexual men, England, 2022. Emerg. Infect. Dis. 28: 2082-2086. https://doi.org/10.3201/eid2810.220960
  47. McCarthy MW. 2022. Recent advances in the diagnosis monkeypox: implications for public health. Expert Rev. Mol. Diagn. 22: 739-744. https://doi.org/10.1080/14737159.2022.2116979
  48. Costello V, Sowash M, Gaur A, Cardis M, Pasieka H, Wortmann G, et al. 2022. Imported monkeypox from international traveler, Maryland, USA, 2021. Emerg. Infect. Dis. 28: 1002.
  49. Adnan N, ul Haq Z, Malik A, Mehmood A, Ishaq U, Faraz M, et al. 2022. Human monkeypox virus: An updated review. Medicine 101: e30406.
  50. Shaheen N, Diab RA, Meshref M, Shaheen A, Ramadan A, Shoib S. 2022. Is there a need to be worried about the new monkeypox virus outbreak? A brief review on the monkeypox outbreak. Ann. Med. Surg. 81: 104396.
  51. Parvin R, Ali A, Nagy A, Zhu Z, Zhao S, Neuhaus J, et al. 2022. Monkeypox virus: A comprehensive review of taxonomy, evolution, epidemiology, diagnosis, prevention, and control regiments so far. Ger. J. Microbiol. 2: 1-15.
  52. Petersen E, Kantele A, Koopmans M, Asogun D, Yinka-Ogunleye A, Ihekweazu C, et al. 2019. Human monkeypox: epidemiologic and clinical characteristics, diagnosis, and prevention. Infect. Dis. Clin. 33: 1027-1043. https://doi.org/10.1016/j.idc.2019.03.001
  53. Altindis M, Puca E, Shapo L. 2022. Diagnosis of monkeypox virus-An overview. Travel Med. Infect. Dis. 50: 102459.
  54. Kabuga AI, El Zowalaty ME. 2019. A review of the monkeypox virus and a recent outbreak of skin rash disease in Nigeria. J. Med. Virol. 91: 533-540. https://doi.org/10.1002/jmv.25348
  55. Delaune D, Iseni F. 2020. Drug development against smallpox: present and future. Antimicrob. Agents Chemother. 64: e01683-19.
  56. Brown K, Leggat PA. 2016. Human monkeypox: current state of knowledge and implications for the future. Trop. Med. Infect. Dis. 1: 8.
  57. Chinwenda VU, Blessed N, Ibe, SNO, Gregory I, Abanobi OC. 2019. Factors associated with the practice of monkey pox preventive behaviours among health workers in Yenagoa LGA, Bayelsa state, Nigeria. IOSR J. Nursing Health Sci. 8: 75-85.
  58. Brown K, Leggat PA. 2016. Human monkeypox: current state of knowledge and implications for the future. Trop. Med. Infect. Dis. 1: 8.
  59. Chakraborty S, Chandran D, Mohapatra RK, Alagawany M, Nahed A, Sharma AK, et al. 2022. Clinical management, antiviral drugs and immunotherapeutics for treating monkeypox. An update on current knowledge and futuristic prospects. Int. J. Surg. 105: 106847.
  60. Cheema AY, Ogedegbe OJ, Munir M, Alugba G, Ojo TK. 2022. Monkeypox: a review of clinical features, diagnosis, and treatment. Cureus 14: e26756.
  61. Gong Q, Wang C, Chuai X, Chiu S. 2022. Monkeypox virus: a reemergent threat to humans. Virol. Sin. 37: 477-482. https://doi.org/10.1016/j.virs.2022.07.006
  62. Schnierle BS. 2022. Monkeypox goes north: Ongoing worldwide monkeypox infections in humans. Viruses 14: 1874.
  63. Deshmukh P, Vora A, Tiwaskar M, Joshi S. 2022. Monkeypox: What do we know so far? A short narrative review of literature. J. Assoc. Physicians India 70: 87-90. https://doi.org/10.5005/japi-11001-0071
  64. Nasir IA, Dangana A, Ojeamiren I, Emeribe AU. 2018. Reminiscing the recent incidence of monkeypox in Nigeria: Its ecologicepidemiology and literature review. Port Harcourt Med. J. 12: 1.
  65. Petersen E, Abubakar I, Ihekweazu C, Heymann D, Ntoumi F, Blumberg L, et al. 2019. Monkeypox-Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era. Int. J. Infect. Dis. 78: 78-84. https://doi.org/10.1016/j.ijid.2018.11.008
  66. Petersen BW, Damon IK, Pertowski CA, Meaney-Delman D, Guarnizo JT, Beigi RH, et al. 2015. Clinical guidance for smallpox vaccine use in a postevent vaccination program. MMWR Wkly Rep. Recomm. Rep. 64: 1-26. https://doi.org/10.15585/mmwr.rr6404a1
  67. Petersen BW, Kabamba J, McCollum AM, Lushima RS, Wemakoy EO, Tamfum JJ, et al. 2019. Vaccinating against monkeypox in the Democratic Republic of the Congo. Antiviral Res. 162: 171-177. https://doi.org/10.1016/j.antiviral.2018.11.004
  68. Liu Y, Rocklov J. 2022. The effective reproductive number of the Omicron variant of SARS-CoV-2 is several times relative to Delta. J. Travel Med. 29: taac037.
  69. Nguyen P, Ajisegiri W, Costantino V, Chughtai A, MacIntyre C. 2021. Reemergence of human monkeypox and declining population immunity in the context of urbanization, Nigeria, 2017-2020. Emerg. Infect. Dis. 27: 1007-1014.