DOI QR코드

DOI QR Code

Effect of phosphatidylserine on cognitive function in the elderly: A systematic review and meta-analysis

  • Kang, Eun Young (Department of Food and Nutrition, Hanyang University) ;
  • Cui, Fengjiao (Department of Food and Nutrition, Hanyang University) ;
  • Kim, Hyun Kyung (Department of Food and Nutrition, Hanyang University) ;
  • Nawaz, Hadia (Department of Food and Nutrition, Hanyang University) ;
  • Kang, Sumin (Department of Food and Nutrition, Hanyang University) ;
  • Kim, Hayoon (Department of Food and Nutrition, Hanyang University) ;
  • Jang, Jihye (Department of Food and Nutrition, Hanyang University) ;
  • Go, Gwang-woong (Department of Food and Nutrition, Hanyang University)
  • 투고 : 2021.11.13
  • 심사 : 2021.11.28
  • 발행 : 2022.02.28

초록

Phosphatidylserine (PS) is an essential component of the cerebral cortex and is associated with cognitive function. In this systematic review, the effects of PS on cognitive function in the elderly population are examined. The literature search included PubMed, EMBASE, Cochrane, and Web of Science databases. Subsequently, nine studies, including five randomized controlled trials and four pre-post studies, were selected. There were 961 participants in the selected studies; PS dosage varied from 100 to 300 mg/d, and the experimental period ranged from 6 weeks to 6 months. Five out of the nine selected studies were assessed to have a 'low' risk of bias, whereas the other four studies were assessed to have 'some concerns' regarding the risk of bias. The results of the meta-analysis concluded that PS had a positive effect on the memory of older adults with cognitive decline. Thus, PS appears to improve age-associated cognitive decline, especially memory, with no adverse effects.

키워드

참고문헌

  1. Balshem H, Helfand M, Schunemann HJ, Oxman AD, Kunz R, Brozek J, Vist GE, Falck-Ytter Y, Meerpohl J, Norris S, Guyatt GH. GRADE guidelines: 3. Rating the quality of evidence. J. Clin. Epidemiol. 64: 401-406 (2011) https://doi.org/10.1016/j.jclinepi.2010.07.015
  2. Baudry M, Massicotte G, Hauge S. Phosphatidylserine increases the affinity of the AMPA/quisqualate receptor in rat brain membranes. Behav. Neural Biol. 55: 137-140 (1991) https://doi.org/10.1016/0163-1047(91)80134-Z
  3. Blokland A, Honig W, Brouns F, Jolles J. Cognition-enhancing properties of subchronic phosphatidylserine (PS) treatment in middleaged rats: comparison of bovine cortex PS with egg PS and soybean PS. Nutrition. 15: 778-783 (1999) https://doi.org/10.1016/S0899-9007(99)00157-4
  4. Burri L, Hoem N, Banni S, Berge K. Marine Omega-3 phospholipids: metabolism and biological activities. Int. J. Mol. Sci. 13: 15401-15419 (2012) https://doi.org/10.3390/ijms131115401
  5. Cenacchi T, Bertoldin T, Farina C, Fiori M G, Crepaldi G, Azzini C, Girardello R, Bagozzi B, Garuti R, Vivaldi P, et al. Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging Clin. Exp. Res. 5: 123-133 (1993) https://doi.org/10.1007/BF03324139
  6. Crook TH, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol. Bull. 28: 61-66 (1992)
  7. Delwaide PJ, Gyselynck-Mambourg AM, Hurlet A, Ylieff M. Double-blind randomized controlled study of phosphatidylserine in senile demented patients. Acta Neurol. Scand. 73: 136-140 (1986) https://doi.org/10.1111/j.1600-0404.1986.tb03254.x
  8. Engel RR, Satzger W, Gunther W, Kathmann N, Bove D, Gerke S, Munch U, Hippius H. Double-blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer type. Eur. Neuropsychopharmacol. 2: 149-155 (1992) https://doi.org/10.1016/0924-977X(92)90025-4
  9. Kang EY, Cui F, Kim HK, Go GW. Bioactive compounds in food for age-associated cognitive decline: A systematic review. Korean J. Food Sci. Technol. 53: 278-289 (2021) https://doi.org/10.9721/KJFST.2021.53.3.278
  10. Hellhammer J, Fries E, Buss C, Engert V, Tuch A, Rutenberg D, Hellhammer D. Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress. 7: 119-126 (2004) https://doi.org/10.1080/10253890410001728379
  11. Hirayama S, Terasawa K, Rabeler R, Hirayama T, Inoue T, Tatsumi Y, Purpura M, Jager R. The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial. J. Hum. Nutr. Diet. 27: 284-291 (2014) https://doi.org/10.1111/jhn.12090
  12. Alzheimer's Disease International. Dementia statistics. Available from: https://www. alzint.org/about/dementia-facts-figures/dementia-statistics/. Accessed Date 2021. 11. 9.
  13. Kim H-Y, Akbar M, Kim Y-S. Phosphatidylserine-dependent neuroprotective signaling promoted by docosahexaenoic acid. Prostag. Leukotr. Ess. (PLEFA). 82: 165-172 (2010) https://doi.org/10.1016/j.plefa.2010.02.025
  14. Kim H-Y, Huang BX, Spector AA. Phosphatidylserine in the brain: metabolism and function. Prog. Lipid Res. 56: 1-18 (2014) https://doi.org/10.1016/j.plipres.2014.06.002
  15. Monteleone P, Maj M, Beinat L, Natale M, Kemali D. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur. J. Clin. Pharmacol. 42: 385-388 (1992) https://doi.org/10.1007/BF00280123
  16. Murman DL. The Impact of Age on Cognition. Seminars in Hearing. 36: 111-121 (2015) https://doi.org/10.1055/s-0035-1555115
  17. NIH. How Is Alzheiner's Disease Treated? Available from: https://www.nia.nih.gov/health/how-alzheimers-disease-treated. Accessed Date 2021. 11. 9
  18. Richter Y, Herzog Y, Cohen T, Steinhart Y. The effect of phosphatidylserine-containing omega-3 fatty acids on memory abilities in subjects with subjective memory complaints: a pilot study. Clin. Interv. Aging. 5: 313-316 (2010)
  19. Richter Y, Herzog Y, Eyal I, Cohen T. Cognitex supplementation in elderly adults with memory complaints: an uncontrolled open label trial. J. Diet. Suppl. 8: 158-168 (2011) https://doi.org/10.3109/19390211.2011.569514
  20. Richter Y, Herzog Y, Lifshitz Y, Hayun R, Zchut S. The effect of soybean-derived phosphatidylserine on cognitive performance in elderly with subjective memory complaints: a pilot study. Clin. Interv. Aging. 8: 557-563 (2013)
  21. Schreiber S, Kampf-Sherf O, Gorfine M, Kelly D, Oppenheim Y, Lerer B. An open trial of plant-source derived phosphatidylserine for treatment of age-related cognitive decline. Isr. J. Psychiatry Relat. Sci. 37: 302-307 (2000)
  22. Singh S, Bajorek B. Defining 'elderly' in clinical practice guidelines for pharmacotherapy. Pharm. Pract. 12: 489 (2014) https://doi.org/10.4321/S1886-36552014000400007
  23. Svennerholm L. Distribution and fatty acid composition of phosphor-glycerides in normal human brain. J. Lipid Res. 9: 570-579 (1968) https://doi.org/10.1016/S0022-2275(20)42702-6
  24. Toita R, Fujita S, Kang J-H. Macrophage uptake behavior and anti-inflammatory response of bovine brain- or soybean-derived phosphatidylserine liposomes. J. Oleo Sci. 67: 1131-1135 (2018) https://doi.org/10.5650/jos.ess18097
  25. Tucker WC, Weber T, Chapman ER. Reconstitution of Ca2+-regulated membrane fusion by synaptotagmin and SNAREs. Science. 304: 435-438 (2004) https://doi.org/10.1126/science.1097196
  26. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement. Geriatr. Cogn. Disord. 38: 39-45 (2014) https://doi.org/10.1159/000357793
  27. Vakhapova V, Cohen T, Richter Y, Herzog Y, Korczyn AD. Phosphatidylserine containing ω-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: A doubleblind placebo-controlled trial. Dement. Geriatr. Cogn. Disord. 29: 467-474 (2010) https://doi.org/10.1159/000310330
  28. Vakhapova V, Richter Y, Cohen T, Herzog Y, Korczyn AD. Safety of phosphatidylserine containing omega-3 fatty acids in non-demented elderly: a double-blind placebo-controlled trial followed by an open-label extension. BMC Neurol. 11: 79 (2011) https://doi.org/10.1186/1471-2377-11-79
  29. Vance JE. Historical perspective: phosphatidylserine and phosphatidylethanolamine from the 1800s to the present. J. Lipid Res. 59: 923-944 (2018) https://doi.org/10.1194/jlr.R084004
  30. WebMD. Types of Dementia. Available from: https://www.webmd.com/alzheimers/guide/alzheimers-dementia. Accessed Date 2021. 11. 9.
  31. World Health Organization. Dementia. Available from: https://www.who.int/news-room/fact-sheets/detail/dementia. Accessed Date 2021. 11. 9.
  32. Zhang YY, Yang LQ, Guo LM. Effect of phosphatidylserine on memory in patients and rats with Alzheimer's disease. Genet. Mol. Res. 14(3): 9325-9333 (2015) https://doi.org/10.4238/2015.August.10.13