Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Nelumbo nucifera Leaf Extract Regulates Lipid Metabolism and Differentiation in 3T3-L1 Adipocytes and db/db Mice

  • Chul-Min, Park (Department of Nutraceutical Resources, Mokpo National University) ;
  • Oh Jin, Min (Department of Nutraceutical Resources, Mokpo National University) ;
  • Min-Seok, Kim (Inhalation Toxicity Research Group, Korea Institute of Toxicology) ;
  • Bhesh Raj, Sharma (Department of Nutraceutical Resources, Mokpo National University) ;
  • Dong Wook, Kim (Department of Nutraceutical Resources, Mokpo National University) ;
  • Dong Young, Rhyu (Department of Nutraceutical Resources, Mokpo National University)
  • Received : 2022.03.21
  • Accepted : 2022.10.18
  • Published : 2022.12.31
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Abstract

Obesity is a complex metabolic disorder that increases the risk for type 2 diabetes, hyperlipidemia, hypertension, and atherosclerosis. In this study, we evaluated the anti-obesity effects of Nelumbo nucifera leaf (NL) extract in 3T3-L1 adipocytes and obese db/db mice. NL extract among various parts (leaf, seed, and root) of N. nucifera most effectively reduced adipogenesis via inhibiting CCAAT enhancer binding protein α (C/EBPα) and peroxisome proliferator activated receptor γ (PPARγ) expression in 3T3-L1 adipocytes. The addition of NL extract enhanced the protein expression of uncoupling protein 2 (UCP2) as compared to untreated 3T3-L1 adipocytes. The oral administration of NL extract (100 mg/kg BW) significantly reduced food efficacy ratio, body weight, and face or total cholesterol level in obese db /db mice. Also, administration of NL extract significantly decreased adipocyte size and C/EBPα or PPARγ expression in the adipose tissues as compared with control (obese db/db mice). Therefore, our results suggest that NL extract among various parts of N. nucifera could be used as a functional food ingredient for the prevention and treatment of metabolic diseases including obesity and diabetes.

Keywords

Acknowledgement

This research was supported by research funds from the Convergence Research Laboratory established by the Mokpo National University (MNU) Innovation Support Project in 2020.

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