Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics (대한후두음성언어의학회지)

The Korean Society of Laryngology, Phoniatrics and Logopedics. (대한후두음성언어의학회)
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Comparison of the Voice Outcome After Injection Laryngoplasty: Unilateral Vocal Fold Paralysis Due to Cancer Nerve Invasion and Iatrogenic Injury

성대주입술 후 음향학적 분석결과 비교: 암의 신경 침윤으로 인한 일측성 성대마비 환자와 수술 후 발생한 일측성 성대마비 환자

  • Yongmin, Cho (Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Guro Hospital) ;
  • Hyunseok, Choi (Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Guro Hospital) ;
  • Kyoung Ho, Oh (Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine) ;
  • Seung-Kuk, Baek (Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine) ;
  • Jeong-Soo, Woo (Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Guro Hospital) ;
  • Soon Young, Kwon (Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine) ;
  • Kwang-Yoon, Jung (Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine) ;
  • Jae-Gu, Cho (Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Guro Hospital)
  • 조용민 (고려대학교 의과대학 구로병원 이비인후-두경부외과학교실) ;
  • 최현석 (고려대학교 의과대학 구로병원 이비인후-두경부외과학교실) ;
  • 오경호 (고려대학교 의과대학 안산병원 이비인후-두경부외과학교실) ;
  • 백승국 (고려대학교 의과대학 안암병원 이비인후-두경부외과학교실) ;
  • 우정수 (고려대학교 의과대학 구로병원 이비인후-두경부외과학교실) ;
  • 권순영 (고려대학교 의과대학 안산병원 이비인후-두경부외과학교실) ;
  • 정광윤 (고려대학교 의과대학 안암병원 이비인후-두경부외과학교실) ;
  • 조재구 (고려대학교 의과대학 구로병원 이비인후-두경부외과학교실)
  • Received : 2022.11.25
  • Accepted : 2022.12.16
  • Published : 2022.12.31
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Abstract

Background and Objectives Injection laryngoplasty is a common method for treatment of unilateral vocal fold paralysis. Unilateral vocal fold paralysis has various causes, including idiopathic, infection, stroke, neurologic condition, surgery and nerve invasion by cancer. To the knowledge of the authors, there was no study on the relationship between the causes of vocal cord paralysis and the outcome of injection laryngoplasty. Therefore, we tried to investigate the difference in the outcomes of injection laryngoplasty between vocal cord paralysis after surgery group and nerve invasion by cancer group. Materials and Method A retrospective analysis was performed for 24 patients who underwent vocal cord injection due to unilateral vocal cord paralysis caused by surgery or nerve invasion by cancer. The objective quality of the voice was assessed by acoustic voice analysis with the Multi-Dimensional Voice Program. Results Both group showed an improvement of fundamental frequemcy (F0), jitter percent, shimmer (percent), and noise to hearmonic ratio (NHR) after injection laryngoplasty. The vocal cord paralysis due to nerve invasion group showed more improvement in both the mean and median value of F0, shimmer percent and NHR than the vocal cord paralysis due to surgery group, but there was not statistically significant. Conclusion Our study did not show a statistically significant difference in outcome between vocal cord paralysis due to cancer invasion group and surgery group, but statistically tendency was suggested. The vocal cord paralysis due to nerve invasion group showed more improvement in both the mean and median value of acoustic voice analysis than surgery group.

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References

  1. Ramadan HH, Wax MK, Avery S. Outcome and changing cause of unilateral vocal cord paralysis. Otolaryngol Head Neck Surg 1998;118(2):199-202. https://doi.org/10.1016/S0194-5998(98)80014-4
  2. Kwon TK. Injection laryngoplasty. Korean J Otorhinolaryngol-Head Neck Surg 2006;49(8):768-80.
  3. Rosen CA, Simpson CB. Operative techniques in laryngology. Berlin: Springer Science & Business Media;2008.
  4. Husain S, Sadoughi B, Mor N, Levin AM, Sulica L. Time course of recovery of idiopathic vocal fold paralysis. Laryngoscope 2018;128(1):148-52. https://doi.org/10.1002/lary.26762
  5. Husain S, Sadoughi B, Mor N, Sulica L. Time course of recovery of iatrogenic vocal fold paralysis. Laryngoscope 2019;129(5):1159-63. https://doi.org/10.1002/lary.27572
  6. Chen P, Piao X, Bonaldo P. Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury. Acta Neuropathol 2015;130(5):605-18.
  7. Menorca RM, Fussell TS, Elfar JC. Nerve physiology: Mechanisms of injury and recovery. Hand Clin 2013;29(3):317-30. https://doi.org/10.1016/j.hcl.2013.04.002
  8. Siu J, Tam S, Fung K. A comparison of outcomes in interventions for unilateral vocal fold paralysis: A systematic review. Laryngoscope 2016;126(7):1616-24. https://doi.org/10.1002/lary.25739
  9. Bakst RL, Wong RJ. Mechanisms of perineural invasion. J Neurol Surg B Skull Base 2016;77(2):96-106. https://doi.org/10.1055/s-0036-1571835
  10. Mau T, Husain S, Sulica L. Pathophysiology of iatrogenic and idiopathic vocal fold paralysis may be distinct. Laryngoscope 2020;130(6):1520-4. https://doi.org/10.1002/lary.28281
  11. Larson DL, Rodin AE, Roberts DK, O'Steen WK, Rapperport AS, Lewis SR. Perineural lymphatics: Myth or fact. Am J Surg 1966;112(4):488-92. https://doi.org/10.1016/0002-9610(66)90309-6
  12. Kobayashi H, Kondo M, Kita R, Hashida H, Shiokawa K, Iwaki K, et al. Cause of recurrent laryngeal nerve paralysis following esophageal cancer surgery and preventive surgical technique along the left recurrent laryngeal nerve. Mini-invasive Surg 2020;4:30.
  13. Miaskiewicz B, Panasiewicz A, Nikiel K, Wlodarczyk E, Gos E, Szkielkowska A. Comparison of 24-month voice outcomes after injection laryngoplasty with calcium hydroxylapatite or hyaluronic acid in patients with unilateral vocal fold paralysis. Am J Otolaryngol 2022;43(1):103207.