Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Neural Organoids, a Versatile Model for Neuroscience

  • Lee, Ju-Hyun (Department of Anatomy, Brain Korea 21 Plus Program for Biomedical Science, Korea University College of Medicine) ;
  • Sun, Woong (Department of Anatomy, Brain Korea 21 Plus Program for Biomedical Science, Korea University College of Medicine)
  • Received : 2021.11.11
  • Accepted : 2021.12.21
  • Published : 2022.02.28
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Abstract

Three-dimensional cultures of human neural tissue/organlike structures in vitro can be achieved by mimicking the developmental processes occurring in vivo. Rapid progress in the field of neural organoids has fueled the hope (and hype) for improved understanding of brain development and functions, modeling of neural diseases, discovery of new drugs, and supply of surrogate sources of transplantation. In this short review, we summarize the state-of-the-art applications of this fascinating tool in various research fields and discuss the reality of the technique hoping that the current limitations will soon be overcome by the efforts of ingenious researchers.

Keywords

Acknowledgement

This work was supported by the Brain Research Program through the National Research Foundation (NRF), which is funded by the Korean Ministry of Science, ICT & Future Planning (NRF-2021M3E5D9021368).

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