Acknowledgement
This study was supported by a research grant of the Health Fellowship Foundation.
References
- Tysnes OB, Storstein A. Epidemiology of Parkinson's disease. J Neural Transm (Vienna). 2017 ; 124(8) : 901-5. https://doi.org/10.1007/s00702-017-1686-y
- Dorszewska J, Kowalska M, Prendecki M, Piekut T, Kozlowska J, Kozubski W. Oxidative stress factors in Parkinson's disease. Neural Regen Res. 2021 ; 16(7) : 1383-91. https://doi.org/10.4103/1673-5374.300980
- Padilla-Godinez FJ, Ramos-Acevedo R, Martinez-Becerril HA, Bernal-Conde LD, Garrido-Figueroa JF, Hiriart M, et al. Protein misfolding and aggregation: the relatedness between Parkinson's disease and hepatic endoplasmic reticulum storage disorders. Int J Mol Sci. 2021 ; 22(22) : 12467. https://doi.org/10.3390/ijms222212467
- Calabresi P, Di Filippo M, Ghiglieri V, Tambasco N, Picconi B. Levodopa-induced dyskinesias in patients with Parkinson's disease: filling the bench-to-bedside gap. Lancet Neurol. 2010 ; 9(11) : 1106-17. https://doi.org/10.1016/S1474-4422(10)70218-0
- Tambasco N, Romoli M, Calabresi P. Levodopa in Parkinson's disease: current status and future developments. Curr Neuropharmacol. 2018 ; 16(8) : 1239-52. https://doi.org/10.2174/ 1570159X15666170510143821
- Armstrong MJ, Okun MS. Diagnosis and treatment of Parkinson disease: a review. JAMA. 2020 ; 323(6) : 548-60. https://doi.org/10.1001/jama.2019.22360
- Ntetsika T, Papathoma PE, Markaki I. Novel targeted therapies for Parkinson's disease. Mol Med. 2021 ; 27(1) : 17. https://doi.org/10.1186/s10020-021-00279-2
- Kim HS, Lee SI, Jeong JK. Systemic review on the research trend of Gastrodiae rhizoma and relationship between the herbology and KCD-code. Kor. J. Herbology. 2016 ; 31 (2) : 21-37. https://doi.org/10.6116/kjh.2016.31.2.21.
- Hsieh CL, Lin JJ, Chiang SY, Su SY, Tang NY, Lin GG, et al. Gastrodia elata modulated activator protein 1 via c-Jun N-terminal kinase signaling pathway in kainic acid-induced epilepsy in rats. J Ethnopharmacol. 2007 ; 109(2) : 241-7. https://doi. org/10.1016/j.jep.2006.07.024
- Lee JY, Jang YW, Kang HS, Moon H, Sim SS, Kim CJ. Anti-inflammatory action of phenolic compounds from Gastrodia elata root. Arch Pharm Res. 2006 ; 29(10) : 849-58. https://doi.org/10.1007/BF02973905
- Kim IS, Choi DK, Jung HJ. Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells. Molecules. 2011 ; 16(7) : 5349-61. https:// doi.org/10.3390/molecules16075349
- Zhou B, Tan J, Zhang C, Wu Y. Neuroprotective effect of polysaccharides from Gastrodia elata blume against corticosterone-induced apoptosis in PC12 cells via inhibition of the endoplasmic reticulum stress-mediated pathway. Mol Med Rep. 2018 ; 17(1) : 1182-90. https://doi.org/10.3892/mmr.2017.7948
- Doo AR, Kim SN, Hahm DH, Yoo HH, Park JY, Lee H, et al. Gastrodia elata Blume alleviates L-DOPA-induced dyskinesia by normalizing FosB and ERK activation in a 6-OHDA-lesioned Parkinson's disease mouse model. BMC Complement Altern Med. 2014 ; 14 : 107. https://doi.org/10.1186/1472-6882-14-107
- He J, Li X, Yang S, Li Y, Lin X, Xiu M, et al. Gastrodin extends the lifespan and protects against neurodegeneration in the drosophila PINK1 model of Parkinson's disease. Food Funct. 2021 ; 12(17) : 7816-24. https://doi.org/10.1039/d1fo00847a
- Kumar H, Kim IS, More SV, Kim BW, Bahk YY, Choi DK. Gastrodin protects apoptotic dopaminergic neurons in a toxin-induced Parkinson's disease model. Evid Based Complement Alternat Med. 2013 ; 2013 : 514095. https://doi.org/10.1155/2013/514095
- Icimoto MY, Ferreira JC, Yokomizo CH, Bim LV, Marem A, Gilio JM, et al. Redox modulation of thimet oligopeptidase activity by hydrogen peroxide. FEBS Open Bio. 2017 ; 7(7) : 1037-50. https://doi.org/10.1002/2211-5463.12245
- Valenzuela R, Costa-Besada MA, Iglesias-Gonzalez J, PerezCostas E, Villar-Cheda B, Garrido-Gil P, et al. Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration. Cell Death Dis. 2016 ; 7(10) : e2427. https://doi.org/10.1038/cddis.2016.327
- Seebauer L, Schneider Y, Drobny A, Plotz S, Koudelka T, Tholey A, et al. Interaction of alpha synuclein and microtubule organization is linked to impaired neuritic integrity in Parkinson's patient-derived neuronal cells. Int J Mol Sci. 2022 ; 23(3) : 1812. https://doi.org/10.3390/ijms23031812
- Hu S, Hu M, Liu J, Zhang B, Zhang Z, Zhou FH, et al. Phosphorylation of Tau and α-synuclein induced neurodegeneration in MPTP mouse model of Parkinson's disease. Neuropsychiatr Dis Treat. 2020 ; 16 ; 651-63. https://doi.org/10.2147/NDT.S235562
- Sarkar S, Olsen AL, Sygnecka K, Lohr KM, Feany MB. α-Synuclein impairs autophagosome maturation through abnormal actin stabilization. PLoS Genet. 2021 ; 17(2) : e1009359. https://doi.org/10.1371/journal.pgen.1009359
- Cuellar J, Vallin J, Svanstrom A, Maestro-Lopez M, BuenoCarrasco MT, Ludlam WG, et al. The molecular chaperone CCT sequesters gelsolin and protects it from cleavage by caspase-3. J Mol Biol. 2022 ; 434(5) : 167399. https://doi.org/10.1016/j.jmb.2021.167399
- Yu M, Luo C, Huang X, Chen D, Li S, Qi H, et al. Amino acids stimulate glycyl-tRNA synthetase nuclear localization for mammalian target of rapamycin expression in bovine mammary epithelial cells. J Cell Physiol. 2019 ; 234(5) : 7608-21. https://doi.org/10.1002/jcp.27523
- Kato Y, Maeda T, Suzuki A, Baba Y. Cancer metabolism: new insights into classic characteristics. Jpn Dent Sci Rev. 2018 ; 54(1) : 8-21. https://doi.org/10.1016/j.jdsr.2017.08.003
- Jiang P, Gan M, Ebrahim AS, Castanedes-Casey M, Dickson DW, Yen SH. Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of α-synuclein oligomers and decrease of neurites. Neurobiol Aging. 2013 ; 34(5) : 1504-15. https://doi.org/10.1016/j.neurobiolaging.2012.11.001
- Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, et al. PKM1 confers metabolic advantages and promotes cell-autonomous tumor cell growth. Cancer Cell. 2018 ; 33(3) : 355-67. https://doi.org/10.1016/j.ccell.2018.02.004
- Li J, Chen L, Qin Q, Wang D, Zhao J, Gao H, et al. Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease. Neurobiol Dis. 2022 ; 163 : 105605. https://doi.org/10.1016/j.nbd.2021.105605
- Loeffler DA, Klaver AC, Coffey MP, Aasly JO, LeWitt PA. Age-related decrease in heat shock 70-kDa protein 8 in cerebrospinal fluid is associated with increased oxidative stress. Front Aging Neurosci. 2016 ; 8 : 178. https://doi.org/10.3389/fnagi.2016.00178
- Niu M, Dai X, Zou W, Yu X, Teng W, Chen Q, et al. Autophagy, endoplasmic reticulum stress and the unfolded protein response in intracerebral hemorrhage. Transl Neurosci. 2017 ; 8 : 37-48. https://doi.org/10.1515/tnsci-2017-0008
- Plowey ED, Cherra SJ 3rd, Liu YJ, Chu CT. Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. J Neurochem. 2008 ; 105(3) : 1048-56. https://doi.org/10.1111/j.1471-4159.2008.05217.x
- Stafa K, Tsika E, Moser R, Musso A, Glauser L, Jones A, et al. Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily. Hum Mol Genet. 2014 ; 23(8) : 2055-77. https://doi.org/10.1093/hmg/ddt600
- Berner AK, Brouwers O, Pringle R, Klaassen I, Colhoun L, McVicar C, et al. Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology. Diabetologia. 2012 ; 55(3) : 845-54. https://doi.org/10.1007/s00125-011-2393-0
- Antognelli C, Palumbo I, Aristei C, Talesa VN. Glyoxalase I inhibition induces apoptosis in irradiated MCF-7 cells via a novel mechanism involving Hsp27, p53 and NF-κB. Br J Cancer. 2014 ; 111(2) : 395-406. https://doi.org/10.1038/bjc.2014.280
- Taoufik E, Kouroupi G, Zygogianni O, Matsas R. Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models. Open Biol. 2018 ; 8(9) : 180138. https://doi.org/10.1098/rsob.180138
- Nakos K, Radler MR, Spiliotis ET. Septin 2/6/7 complexes tune microtubule plus-end growth and EB1 binding in a concentration- and filament-dependent manner. Mol Biol Cell. 2019 ; 30(23) : 2913-28. https://doi.org/10.1091/mbc.E19-07-0362
- Bowen JR, Hwang D, Bai X, Roy D, Spiliotis ET. Septin GTPases spatially guide microtubule organization and plus end dynamics in polarizing epithelia. J Cell Biol. 2011 ; 194(2) : 187-97. https://doi.org/10.1083/jcb.201102076
- Kuck U, Radchenko D, Teichert I. STRIPAK, a highly conserved signaling complex, controls multiple eukaryotic cellular and developmental processes and is linked with human diseases. Biol Chem. 2019 ; 400(8) : 1005-22. https://doi.org/10.1515/hsz2019-0173
- Neisch AL, Neufeld TP, Hays TS. A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation. J Cell Biol. 2017 ; 216(2) : 441-61. https://doi.org/10.1083/jcb.201606082
- Wilkinson KD, Lee KM, Deshpande S, Duerksen-Hughes P, Boss JM, Pohl J. The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. Science. 1989 ; 246(4930) : 670-3. https://doi.org/10.1126/science.2530630
- Reinicke AT, Laban K, Sachs M, Kraus V, Walden M, Damme M, et al. Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks. Proc Natl Acad Sci U S A. 2019 ; 116(16) : 7963-72. https://doi.org/10.1073/pnas.1812413116
- Huynh TKT, Mai TTT, Huynh MA, Yoshida H, Yamaguchi M, Dang TTP. Crucial roles of ubiquitin carboxy-terminal hydrolase L1 in motor neuronal health by Drosophila Model. Antioxid Redox Signal. 2022 ; 37(4-6) : 257-73. https://doi.org/10.1089/ars.2021.0057