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Current concepts of Kimura disease: pathophysiology and evolution of treatment

  • Woo Ju, Kim (Department of Plastic and Reconstructive Surgery, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University School of Medicine) ;
  • Han Koo, Kim (Department of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Chung-Ang University School of Medicine)
  • 투고 : 2022.11.26
  • 심사 : 2022.12.19
  • 발행 : 2022.12.20

초록

Kimura disease (KD) is a chronic inflammatory disorder that frequently involves the subcutaneous tissue of the head and neck regions. It often manifests as regional lymphadenopathy or salivary gland enlargement in the affected area. The histologic architecture of the lymph nodes in KD patients is preserved, while the affected tissues show follicular hyperplasia and eosinophilic infiltration. No single modality has been adopted as an optimal treatment for KD. This article concentrates on the fundamental features of KD and reviews current approaches to its treatment.

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참고문헌

  1. Sun QF, Xu DZ, Pan SH, Ding JG, Xue ZQ, Miao CS, et al. Kimura disease: review of the literature. Intern Med J 2008;38:668-72.  https://doi.org/10.1111/j.1445-5994.2008.01711.x
  2. Lee CC, Feng IJ, Chen YT, Weng SF, Chan LP, Lai CS, et al. Treatment algorithm for Kimura's disease: a systematic review and meta-analysis of treatment modalities and prognostic predictors. Int J Surg 2022;100:106591. 
  3. Yuen HW, Goh YH, Low WK, Lim-Tan SK. Kimura's disease: a diagnostic and therapeutic challenge. Singapore Med J 2005;46:179-83. 
  4. Hobeika CM, Mohammed TL, Johnson GL, Hansen K. Kimura's disease: case report and review of the literature. J Thorac Imaging 2005;20:298-300.  https://doi.org/10.1097/01.rti.0000181522.10263.c5
  5. Abuel-Haija M, Hurford MT. Kimura disease. Arch Pathol Lab Med 2007;131:650-1.  https://doi.org/10.5858/2007-131-650-KD
  6. Kim HT. Eosinophilic hyperplastic lymphogranuloma, comparison with Mikulicz's disease. Chinese Med J 1937;23:699-70. 
  7. Kimura T. Unusual granulation combined with hyperplastic change of lymphatic tissue. Trans Soc Pathol Jpn 1948;37:179-80. 
  8. Hamrick HJ, Jennette JC, LaForce CF. Kimura's disease: report of a pediatric case in the United States. J Allergy Clin Immunol 1984;73(5 Pt 1):561-6.  https://doi.org/10.1016/0091-6749(84)90511-6
  9. Yoganathan P, Meyer DR, Farber MG. Bilateral lacrimal gland involvement with Kimura disease in an African American male. Arch Ophthalmol 2004;122:917-9.  https://doi.org/10.1001/archopht.122.6.917
  10. Jaber K. Kimura's disease in an Arab female. Histopathology 1996;29:76-8. 
  11. Chen H, Thompson LD, Aguilera NS, Abbondanzo SL. Kimura disease: a clinicopathologic study of 21 cases. Am J Surg Pathol 2004;28:505-13.  https://doi.org/10.1097/00000478-200404000-00010
  12. Natov SN, Strom JA, Ucci A. Relapsing nephrotic syndrome in a patient with Kimura's disease and IgA glomerulonephritis. Nephrol Dial Transplant 1998;13:2358-63.  https://doi.org/10.1093/ndt/13.9.2358
  13. Chan TM, Chan PC, Chan KW, Cheng IK. IgM nephropathy in a patient with Kimura's disease. Nephron 1991;58:489-90.  https://doi.org/10.1159/000186489
  14. Sakamoto M, Komura A, Nishimura S. Hematoserological analysis of Kimura's disease for optimal treatment. Otolaryngol Head Neck Surg 2005;132:159-60.  https://doi.org/10.1016/j.otohns.2004.04.030
  15. Ohta N, Okazaki S, Fukase S, Akatsuka N, Aoyagi M, Yamakawa M. Serum concentrations of eosinophil cationic protein and eosinophils of patients with Kimura's disease. Allergol Int 2007;56:45-9.  https://doi.org/10.2332/allergolint.O-06-442
  16. Kuo TT, Shih LY, Chan HL. Kimura's disease: involvement of regional lymph nodes and distinction from angiolymphoid hyperplasia with eosinophilia. Am J Surg Pathol 1988;12:843-54.  https://doi.org/10.1097/00000478-198811000-00005
  17. Katagiri K, Itami S, Hatano Y, Yamaguchi T, Takayasu S. In vivo expression of IL-4, IL-5, IL-13 and IFN-gamma mRNAs in peripheral blood mononuclear cells and effect of cyclosporin A in a patient with Kimura's disease. Br J Dermatol 1997;137:972-7.  https://doi.org/10.1046/j.1365-2133.1997.19962077.x
  18. Kimura Y, Pawankar R, Aoki M, Niimi Y, Kawana S. Mast cells and T cells in Kimura's disease express increased levels of interleukin-4, interleukin-5, eotaxin and RANTES. Clin Exp Allergy 2002;32:1787-93.  https://doi.org/10.1046/j.1365-2222.2002.01552.x
  19. Lu HJ, Tsai JD, Sheu JC, Tzen CY, Tsai TC, Lin CC, et al. Kimura disease in a patient with renal allograft failure secondary to chronic rejection. Pediatr Nephrol 2003;18:1069-72.  https://doi.org/10.1007/s00467-003-1206-1
  20. Barber J, Dawes P. A rare cause of rash, eosinophilia and asthma in rheumatology. Rheumatology (Oxford) 2002;41:1329-30.  https://doi.org/10.1093/rheumatology/41.11.1329
  21. Khoo BP, Chan R. Kimura disease: 2 case reports and a literature review. Cutis 2002;70:57-61. 
  22. Mitsui M, Ogino S, Ochi K, Ohashi T. Three cases of eosinophilic lymphfolliculoid granuloma of the soft tissue originating from the parotid gland. Acta Otolaryngol Suppl 1996;522:130-2. 
  23. Chim CS, Shek Wh, Liang R, Kowng YL. Kimura's disease: no evidence of clonality. Br J Ophthalmol 1999;83:878. 
  24. Jang KA, Ahn SJ, Choi JH, Sung KJ, Moon KC, Koh JK, et al. Polymerase chain reaction (PCR) for human herpesvirus 8 and heteroduplex PCR for clonality assessment in angiolymphoid hyperplasia with eosinophilia and Kimura's disease. J Cutan Pathol 2001;28:363-7.  https://doi.org/10.1034/j.1600-0560.2001.280705.x
  25. Terakado N, Sasaki A, Takebayashi T, Matsumura T, Kojou T. A case of Kimura's disease of the hard palate. Int J Oral Maxillofac Surg 2002;31:222-4.  https://doi.org/10.1054/ijom.2001.0142
  26. Okami K, Onuki J, Sakai A, Tanaka R, Hagino H, Takahashi M. Sleep apnea due to Kimura's disease of the larynx: report of a case. ORL J Otorhinolaryngol Relat Spec 2003;65:242-4.  https://doi.org/10.1159/000073125
  27. Tseng CF, Lin HC, Huang SC, Su CY. Kimura's disease presenting as bilateral parotid masses. Eur Arch Otorhinolaryngol 2005;262:8-10.  https://doi.org/10.1007/s00405-003-0677-9
  28. Fouda MA, Gheith O, Refaie A, El-Saeed M, Bakr A, Wafa E, et al. Kimura disease: a case report and review of the literature with a new management protocol. Int J Nephrol 2011;2010:673908. 
  29. Goldenberg D, Gatot A, Barki Y, Leiberman A, Fliss DM. Computerized tomographic and ultrasonographic features of Kimura's disease. J Laryngol Otol 1997;111:389-91.  https://doi.org/10.1017/S0022215100137417
  30. Chartapisak W, Opastirakul S. Steroid-resistant nephrotic syndrome associated with Kimura's disease. Am J Nephrol 2002;22:381-4.  https://doi.org/10.1159/000065232
  31. Kung IT, Gibson JB, Bannatyne PM. Kimura's disease: a clinicopathological study of 21 cases and its distinction from angiolymphoid hyperplasia with eosinophilia. Pathology 1984;16:39-44.  https://doi.org/10.3109/00313028409067909
  32. Akosa AB, Sherif A, Maidment CG. Kimura's disease and membranous nephropathy. Nephron 1991;58:472-4.  https://doi.org/10.1159/000186482
  33. Armstrong WB, Allison G, Pena F, Kim JK. Kimura's disease: two case reports and a literature review. Ann Otol Rhinol Laryngol 1998;107:1066-71.  https://doi.org/10.1177/000348949810701212
  34. Som PM, Biller HF. Kimura disease involving parotid gland and cervical nodes: CT and MR findings. J Comput Assist Tomogr 1992;16:320-2.  https://doi.org/10.1097/00004728-199203000-00028
  35. Park SW, Kim HJ, Sung KJ, Lee JH, Park IS. Kimura disease: CT and MR imaging findings. AJNR Am J Neuroradiol 2012;33:784-8.  https://doi.org/10.3174/ajnr.A2854
  36. Oguz KK, Ozturk A, Cila A. Magnetic resonance imaging findings in Kimura's disease. Neuroradiology 2004;46:855-8.  https://doi.org/10.1007/s00234-004-1248-5
  37. Wang TF, Liu SH, Kao CH, Chu SC, Kao RH, Li CC. Kimura's disease with generalized lymphadenopathy demonstrated by positron emission tomography scan. Intern Med 2006;45:775-8.  https://doi.org/10.2169/internalmedicine.45.1618
  38. Googe PB, Harris NL, Mihm MC Jr. Kimura's disease and angiolymphoid hyperplasia with eosinophilia: two distinct histopathological entities. J Cutan Pathol 1987;14:263-71.  https://doi.org/10.1111/j.1600-0560.1987.tb00498.x
  39. Don DM, Ishiyama A, Johnstone AK, Fu YS, Abemayor E. Angiolymphoid hyperplasia with eosinophilia and vascular tumors of the head and neck. Am J Otolaryngol 1996;17:240-5.  https://doi.org/10.1016/S0196-0709(96)90088-5
  40. Ren S, Li XY, Wang F, Zhang P, Zhang Y, Li GS, et al. Nephrotic syndrome associated with Kimura's disease: a case report and literature review. BMC Nephrol 2018;19:316. 
  41. Nakahara C, Wada T, Kusakari J, Kanemoto K, Kinugasa H, Sibasaki M, et al. Steroid-sensitive nephrotic syndrome associated with Kimura disease. Pediatr Nephrol 2000;14:482-5.  https://doi.org/10.1007/s004670050798
  42. Ye P, Ma DQ, Yu GY, Gao Y, Peng X. Comparison of the efficacy of different treatment modalities for Kimura's disease. Int J Oral Maxillofac Surg 2017;46:350-4. 
  43. Viswanatha B. Kimura's disease in children: a 9 years prospective study. Int J Pediatr Otorhinolaryngol 2007;71:1521-5.  https://doi.org/10.1016/j.ijporl.2007.05.023
  44. Birol A, Bozdogan O, Keles H, Kazkayasi M, Bagci Y, Kara S, et al. Kimura's disease in a Caucasian male treated with cyclosporine. Int J Dermatol 2005;44:1059-60.  https://doi.org/10.1111/j.1365-4632.2004.02527.x
  45. Senel MF, Van Buren CT, Etheridge WB, Barcenas C, Jammal C, Kahan BD. Effects of cyclosporine, azathioprine and prednisone on Kimura's disease and focal segmental glomerulosclerosis in renal transplant patients. Clin Nephrol 1996;45:18-21. 
  46. Kaneko K, Aoki M, Hattori S, Sato M, Kawana S. Successful treatment of Kimura's disease with cyclosporine. J Am Acad Dermatol 1999;41(5 Pt 2):893-4.  https://doi.org/10.1016/S0190-9622(99)70354-3
  47. Teraki Y, Katsuta M, Shiohara T. Lichen amyloidosus associated with Kimura's disease: successful treatment with cyclosporine. Dermatology 2002;204:133-5.  https://doi.org/10.1159/000051831
  48. Wang YS, Tay YK, Tan E, Poh WT. Treatment of Kimura's disease with cyclosporine. J Dermatolog Treat 2005;16:242-4.  https://doi.org/10.1080/09546630510044003
  49. Miki H, Tsuboi H, Kaneko S, Takahashi H, Yokosawa M, Asashima H, et al. A case of refractory Kimura disease with a buccal bulky mass successfully treated with low-dose cyclosporine A: report and review of the literature. Allergol Int 2016;65:212-4.  https://doi.org/10.1016/j.alit.2015.10.008
  50. Sato S, Kawashima H, Kuboshima S, Watanabe K, Kashiwagi Y, Takekuma K, et al. Combined treatment of steroids and cyclosporine in Kimura disease. Pediatrics 2006;118:e921-3.  https://doi.org/10.1542/peds.2006-0487
  51. Maleki D, Sayyah A, Rahimi-Rad MH, Gholami N. Kimura's disease with eosinophilic panniculitis--treated with cyclosporine: a case report. Allergy Asthma Clin Immunol 2010;6:5. 
  52. Nonaka M, Sakitani E, Yoshihara T. Anti-IgE therapy to Kimura's disease: a pilot study. Auris Nasus Larynx 2014;41:384-8.  https://doi.org/10.1016/j.anl.2013.12.006
  53. Yu B, Xu G, Liu X, Yin W, Chen H, Sun B. Kimura's disease affecting multiple body parts in a 57-year-old female patient: a case report. Allergy Asthma Clin Immunol 2019;15:84. 
  54. Buchdunger E, Cioffi CL, Law N, Stover D, Ohno-Jones S, Druker BJ, et al. Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther 2000;295:139-45. 
  55. Hareyama M, Oouchi A, Nagakura H, Asakura K, Saito A, Satoh M, et al. Radiotherapy for Kimura's disease: the optimum dosage. Int J Radiat Oncol Biol Phys 1998;40:647-51.  https://doi.org/10.1016/S0360-3016(97)00813-4
  56. Chang AR, Kim K, Kim HJ, Kim IH, Park CI, Jun YK. Outcomes of Kimura's disease after radiotherapy or nonradiotherapeutic treatment modalities. Int J Radiat Oncol Biol Phys 2006;65:1233-9.  https://doi.org/10.1016/j.ijrobp.2006.02.024
  57. Ye P, Wei T, Yu GY, Wu LL, Peng X. Comparison of local recurrence rate of three treatment modalities for Kimura disease. J Craniofac Surg 2016;27:170-4.  https://doi.org/10.1097/SCS.0000000000002337
  58. Day TA, Abreo F, Hoajsoe DK, Aarstad RF, Stucker FJ. Treatment of Kimura's disease: a therapeutic enigma. Otolaryngol Head Neck Surg 1995;112:333-7.  https://doi.org/10.1016/S0194-5998(95)70259-8
  59. Lin YY, Jung SM, Ko SF, Toh CH, Wong AM, Chen YR, et al. Kimura's disease: clinical and imaging parameters for the prediction of disease recurrence. Clin Imaging 2012;36:272-8.  https://doi.org/10.1016/j.clinimag.2011.11.002
  60. Tsukagoshi H, Nagashima M, Horie T, Oyama T, Yoshii A, Sato T, et al. Kimura's disease associated with bronchial asthma presenting eosinophilia and hyperimmunoglobulinemia E which were attenuated by suplatast tosilate (IPD-1151T). Intern Med 1998;37:1064-7.  https://doi.org/10.2169/internalmedicine.37.1064
  61. Ben-Chetrit E, Amir G, Shalit M. Cetirizine: an effective agent in Kimura's disease. Arthritis Rheum 2005;53:117-8.  https://doi.org/10.1002/art.20908
  62. Boulanger E, Gachot B, Verkarre V, Valensi F, Brousse N, Hermine O. All-trans-retinoic acid in the treatment of Kimura's disease. Am J Hematol 2002;71:66. 
  63. Kanekura T, Usuki K, Kanzaki T. Skin disorders with prominent eosinophilic infiltration treated successfully with nicotine: report of two cases. Dermatology 2004;208:153-7.  https://doi.org/10.1159/000076492
  64. Connelly A, Powell HR, Chan YF, Fuller D, Taylor RG. Vincristine treatment of nephrotic syndrome complicated by Kimura disease. Pediatr Nephrol 2005;20:516-8. https://doi.org/10.1007/s00467-004-1754-z