International Journal of Industrial Entomology and Biomaterials

  • 제45권2호
  • /
  • Pages.126-130
  • /
  • 2022
  • /
  • 3022-7542(pISSN)
  • /
  • 2586-4785(eISSN)
한국잠사학회 (Korean Society of Sericultural Science)
권호 표지
DOI QR코드

DOI QR Code

The Juhwangjam (JH) 3rd day of fifth instar silkworm exhibits antioxidative properties and prevents high-fat diet-induced hypercholesterolemia

  • Ji Hae, Lee (Department of Agricultural Biology, National Institute of Agricultural Sciences, RDA) ;
  • Yeon-Ji, Kim (Korean Medicine-Application Center, Korea Institute of Oriental Medicine) ;
  • Kyungho, Kim (Korean Medicine-Application Center, Korea Institute of Oriental Medicine) ;
  • Hyun Bok, Kim (Department of Agricultural Biology, National Institute of Agricultural Sciences, RDA) ;
  • HaeYong, Kweon (Department of Agricultural Biology, National Institute of Agricultural Sciences, RDA)
  • 투고 : 2022.11.28
  • 심사 : 2022.12.16
  • 발행 : 2022.12.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The silkworm is a food material that can simultaneously ingest phytochemicals from mulberry leaves, proteins with essential amino acids, and fatty acids. They are known to have hypoglycemic properties; however, further functional investigation is needed. In this study, four varieties of 3rd day of fifth instar silkworm with different cocoon colors, namely Baegokjam (BG), Goldensilk (GS), Yeonnokjam (YN), and Juhwangjam (JH), were compared in terms of antioxidant properties and cholesterol-lowering effect. JH, which had the highest polyphenol content (+38% vs. GS, p<0.05) showed high antioxidant efficacy. Treatment with JH also resulted in the lowest cholesterol biosynthesis enzyme activity (28% vs. control, p<0.05). In the animal study, high-fat diet (HFD)-fed mice that were orally administered JH extract for 12 weeks showed lower body weight gain (-10.4% vs. HFD, p<0.05) and serum total cholesterol levels (-12.7% vs. HFD, p<0.05). Comparing the varieties, JH had the highest effect. In future studies, analysis of the active ingredients according to their variety should be done.

키워드

과제정보

This research activity was supported by the 'Research Program for Agriculture Science and Technology Development' (Grant No. PJ01510702), National Institute of Agricultural Sciences, Rural Development Administration, Republic of Korea.

참고문헌

  1. Chambers KF, Day PE, Aboufarrag HT, Kroon PA (2019) Polyphenol effects on cholesterol metabolism via bile acid biosynthesis, CYP7A1: a review. Nutrients 11, 2588. https://doi.org/10.3390/nu11112588
  2. Ghalei S, Handa H (2022) A review on antibacterial silk fibroin-based biomaterials: current state and prospects. Mater Today Chem 23, 100673. https://doi.org/10.1016/j.mtchem.2021.100673
  3. Ji SD, Kim NS, Kweon H, Choi BH, Kim KY, Koh YH (2016) Nutrition composition differences among steamed and freeze-dried mature silkworm larval powders made from 3 Bombyx mori varieties weaving different colored cocoons. Int J Indust Entomol 33, 6-14. https://doi.org/10.7852/IJIE.2016.33.1.6
  4. Kang PD, Sung GB, Kim KY, Lee HS, Kim MJ, Ji SD, et al. (2011) Breeding of new silkworm strain yeonnokjam. Int J Indust Entomol 23, 175-178 https://doi.org/10.7852/IJIE.2011.23.1.175
  5. Kim SH, Jo YY, Kweon H, Lee JH (2021) Effect of extraction conditions on radical scavenging and cholesterol metabolism regulating capacity of silkworm larvae. Int J Indust Entomol 43, 45-51.
  6. Kim SW, Park JW, Kim SB, Yu JH, Hong JW, Kang SK, et al. (2020) A new breed of silkworm variety, Juhwangjam, for light pink cocoon. Int J Indust Entomol 40, 51-55. https://doi.org/10.7852/IJIE.2020.40.2.51
  7. Kweon HY, Lee KG, Park KY, Kang SW, Kang PD, Kim MJ, et al. (2012) Cocoon filament quality of a special silkworm variety, Golden Silk. Int J Indust Entomol 24, 17-21. https://doi.org/10.7852/IJIE.2012.24.1.017
  8. Lee JH, Lee BK, Park HH, Lee BW, Woo KS, Kim HJ, et al. (2019) Oat germination and ultrafiltration process improves the polyphenol and avenanthramide contents with protective effect in oxidative-damaged HepG2 cells. J Food Biochem 43, e12799.
  9. Lee JH, Oh JH, Kim DW, Kim SG, Kweon H (2022) The difference in bone morphogenic protein-2 expression level among Bombyx mori subspecies, Int J Indust Entomol 45(2), in press.
  10. Lee JH, Son Y, Lee BK, Lee B, Kim HJ, Park JY, et al. (2018) Analysis of total polyphenol content and antioxidant activity in puffed oats. Korean J Food Sci Technol 50, 117-121. https://doi.org/10.9721/KJFST.2018.50.1.117
  11. Lee SP, Hong KW, Sohn KW, Mah YI, Kim KY (1984) Breeding of new silkworm variety "Baegokjam". Res Rept RDA 26, 58-64
  12. Nguyen P, Kim KY, Kim AY, Kim NS, Kweon H, Ji SD, et al. (2016) Increased healthspan and resistance to Parkinson's disease in Drosophila by boiled and freeze-dried mature silk worm larval powder. J Asia Pac Entomol 19, 551-561. https://doi.org/10.1016/j.aspen.2016.05.003
  13. Park SJ, Kim KY, Baik MY, Koh YH (2022) Sericulture and the edibleinsect industry can help humanity survive: insects are more than just bugs, food, or feed. Food Sci Biotechnol, 1-12.
  14. Perron NR, Brumaghim JL (2009) A review of the antioxidant mechanisms of polyphenol compounds related to iron binding. Cell Biochem Biophys 53, 75-100.  https://doi.org/10.1007/s12013-009-9043-x
  15. Sharpe LJ, Brown AJ (2013) Cont rolling cholesterol synthesis beyond 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR). J Biol Chem. 288, 18707-18715. https://doi.org/10.1074/jbc.R113.479808
  16. Wannee S, Luchai B (2020) 1-Deoxynojirimycin and polyphenolic composition and antioxidant activity of different native Thai silkworm (Bombyx mori) larvae. J King Saud Univ Sci 32, 2762-2766. https://doi.org/10.1016/j.jksus.2020.06.012