International Journal of Industrial Entomology and Biomaterials

  • 제45권2호
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  • Pages.108-114
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  • 2022
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  • 3022-7542(pISSN)
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  • 2586-4785(eISSN)
한국잠사학회 (Korean Society of Sericultural Science)
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Immune-enhancing effects of Protaetia brevitarsis seulensis larvae extracts on RAW264.7 macrophages

  • Eu-Jin, Ban (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • Bong Sun, Kim (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • Ra-Yeong, Choi (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • In-Woo, Kim (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • Minchul, Seo (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • Jae Sam, Hwang (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) ;
  • Joon Ha, Lee (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration)
  • 투고 : 2022.11.01
  • 심사 : 2022.12.19
  • 발행 : 2022.12.30
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초록

Protaetia brevitarsis seulensis larva is well-known as an edible insect. The present study aimed to explore the immune-enhancing effect of 30% ethanol extract of Protaetia brevitarsis seulensis larvae (PBE) in RAW264.7 macrophage cells. PBE were not cytotoxic to RAW264.7 cells and nitric oxide production increased on PBE treatment in a dose-dependent manner. Furthermore, PBE significantly promoted the expression of immune-related mediators (Inos and COX-2) and cytokines (TNF-α, IL-6, and IL-1β) and the phosphorylation of MAPKs (ERK, p38, and JNK). Taken together, the immune-enhancing effects of 30% ethanol extract of PBE in vitro were identified. These findings can be used as data for the development of edible insect-based functional foods that improve immune function.

키워드

과제정보

This study was conducted with the support of "Cooperative Research Program for Agriculture Science and Technology Development (Project no. PJ01594001), Rural Development Administration, Republic of Korea

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