Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
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Optimal Combination of Acupoints Based on Network Analysis for Chemotherapy-Induced Peripheral Neuropathy

네트워크 분석에 기반한 항암화학요법으로 유발된 말초신경병증의 최적 경혈 조합

  • Kim, Min-Woo (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Woosuk University) ;
  • Kim, Joong-Il (Digital Health Research Division, Korea Institute of Oriental Medicine) ;
  • Lee, Jin-Hyun (Institute for Integrative Medicine, Catholic Kwandong University International St. Mary's Hospital) ;
  • Jo, Dong-Chan (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Woosuk University) ;
  • Kang, Su-Bin (Department of Korean Medicine Neuropsychiatry, College of Korean Medicine, Woosuk University) ;
  • Lee, Ji-Won (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Woosuk University) ;
  • Park, Tae-Yong (Institute for Integrative Medicine, Catholic Kwandong University International St. Mary's Hospital) ;
  • Ko, Youn-Seok (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Woosuk University)
  • 김민우 (우석대학교 한의과대학 한방재활의학교실) ;
  • 김중일 (한국한의학연구원 디지털임상연구부) ;
  • 이진현 (가톨릭관동대학교 국제성모병원 한의과) ;
  • 조동찬 (우석대학교 한의과대학 한방재활의학교실) ;
  • 강수빈 (우석대학교 한의과대학 한방신경정신과학교실) ;
  • 이지원 (우석대학교 한의과대학 한방재활의학교실) ;
  • 박태용 (가톨릭관동대학교 국제성모병원 한의과) ;
  • 고연석 (우석대학교 한의과대학 한방재활의학교실)
  • Received : 2021.12.15
  • Accepted : 2022.01.03
  • Published : 2022.01.31
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Abstract

Objectives This study aimed to identify optimal combinations of acupoints used to treat chemotherapy-induced peripheral neuropathy (CIPN). Methods We searched four international databases (MEDLINE, EMBASE, the Allied and Complementary Medicine Databases [AMED], and China National Knowledge Infrastructure [CNKI]) and five Korean databases (DBpia, Research Information Sharing Service [RISS], Korean Studies Information Service System [KISS], Oriental Medicine Advanced Searching Integrated System [OASIS], and KoreaMed) to identify randomized controlled trials (RCTs) that used acupuncture to treat CIPN. Network analysis was performed on the acupoints used in more than three included articles. We constructed a network by calculating the Jaccard similarity coefficient between acupoints and applied minimum spanning tree. Then, modularity analysis, degree centrality (Cd), and betweenness centrality (Cb) were used to analyze properties of the acupoints. Results A total of 25 articles were included. 24 acupoints were extracted from 25 articles. The combinations of acupoints having the highest Jaccard similarity coefficient were {EX-UE9, EX-LE10} and {ST36, SP6}. In the modularity analysis, acupoints were classified to six modules. ST40, EX-UE11, and KI6 had the highest Cd value while ST40, GB34 had the highest Cb value. Conclusions This study found the systematic framework of acupoint combinations used in CIPN studies. This study is expected to provide new perspectives of CIPN treatment to therapists. A RCT is in progress of using the network of this study as a guideline. If significant results are derived from the RCT, it will be possible to lay the groundwork to consider acupuncture for CIPN treatment.

Keywords

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