The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effect of Fermented Soy Bean Extract Containing Herbal Medicines (Godjang) on Blood Glucose Levels and Histomorphology in Streptozotocin-induced Diabetic Rat

한약재 함유 대두발효 추출물이 streptozotocin으로 유발된 당뇨 흰쥐의 혈당 및 조직형태학적 변화에 미치는 영향

  • Jo, Chang Suk (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University) ;
  • Kim, So Young (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University) ;
  • Choi, Moon-Yeol (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University) ;
  • Kim, Mi Hyung (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University) ;
  • Kim, Mi Ryeo (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University) ;
  • Seo, Bu-il (Department of Herbal Pharmacology, College of Korean Medicine, Daegu Haany University)
  • 조창숙 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 김소영 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 최문열 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 김미형 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 김미려 (대구한의대학교 한의과대학 본초약리학교실) ;
  • 서부일 (대구한의대학교 한의과대학 본초약리학교실)
  • Received : 2021.12.13
  • Accepted : 2022.01.25
  • Published : 2022.01.30
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Abstract

Objective : This study was designed to investigate anti-diabetic effects of fermented soy bean extract with herbal medicines (Godjang) in diabetic rat models induced by streptozotocin (STZ) injection. Method : Changes in body weight, drinking water, and food intake were observed for 4 weeks before and after induction of diabetes mellitus in rats. The anti-diabetic capacity of Godjang was analyzed by fasting blood glucose (FBG) every week. Also, after 4 weeks of administration, the oral glucose tolerance test (OGTT) was performed, and then blood levels of insulin were checked. And serum levels of total cholesterol and triglycerides were determined. Histomorphological changes of liver, kidney and pancreatic tissues were also observed in STZ-induced diabetic rats and Godjang administered rats. Result : In Godjang administered group, body weight and water intake were more lower than that of STZ-induced diabetic rats. FBG was decreased in the Godjang administered group than STZ-induced diabetic group. According to OGTT, blood glucose levels at 30 minutes and 60 minutes significantly decreased in Godjang administered group than in STZ-induced diabetic control group. Administration of Godjang extract for 4W significantly decreased levels of serum glucose, total cholesterol (TC), triglycerides (TG) in diabetic rats. In histomorphological analysis of kidney, liver, Godjang administrated groups showed the inhibition of pathological damage. Conclusion : These results suggest that Godjang extract has an anti-diabetic action through decrease in serum glucose, TC, TG levels and recovery of the morphological changes in kidney and liver in STZ-induced diabetic rats.

Keywords

Acknowledgement

이 논문은 대한민국 정부(과학기술정보통신부)의 재원으로 한국연구재단의 지원을 받아 수행되었습니다. (No. 2021R1A2C201471711).

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