Acknowledgement
This research was funded by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education [2016R1D1A1B03931593].
References
- Bluher M. Adipose tissue dysfunction in obesity. Exp Clin Endocrinol Diabetes 2009;117:241-50. https://doi.org/10.1055/s-0029-1192044
- Wang S, Moustaid-Moussa N, Chen L, Mo H, Shastri A, Su R, Bapat P, Kwun I, Shen CL. Novel insights of dietary polyphenols and obesity. J Nutr Biochem 2014;25:1-18. https://doi.org/10.1016/j.jnutbio.2013.09.001
- Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 2006;444:847-53. https://doi.org/10.1038/nature05483
- Jung UJ, Choi MS. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci 2014;15:6184-223. https://doi.org/10.3390/ijms15046184
- Kloting N, Bluher M. Adipocyte dysfunction, inflammation and metabolic syndrome. Rev Endocr Metab Disord 2014;15:277-87. https://doi.org/10.1007/s11154-014-9301-0
- Kopelman PG. Obesity as a medical problem. Nature 2000;404:635-43. https://doi.org/10.1038/35007508
- Banack HR, Kaufman JS. The obesity paradox: understanding the effect of obesity on mortality among individuals with cardiovascular disease. Prev Med 2014;62:96-102. https://doi.org/10.1016/j.ypmed.2014.02.003
- Blair SN, Brodney S. Effects of physical inactivity and obesity on morbidity and mortality: current evidence and research issues. Med Sci Sports Exerc 1999;31 Suppl:S646-62. https://doi.org/10.1097/00005768-199911001-00025
- Kim AR, Jin Q, Jin HG, Ko HJ, Woo ER. Phenolic compounds with IL-6 inhibitory activity from Aster yomena. Arch Pharm Res 2014;37:845-51. https://doi.org/10.1007/s12272-013-0236-x
- Seo SW. Protective effects of ethanol extract from Aster Yomena on acute pancreatitis. J Physiol Pathol Korean Med 2019;33:109-15. https://doi.org/10.15188/kjopp.2019.04.33.2.109
- Jung BM, Lim SS, Park YJ, Bae SJ. Inhibitory effects on cell survival and quinone reductase induced activity of Aster yomena fractions on human cancer cells. J Korean Soc Food Sci Nutr 2005;34:8-12. https://doi.org/10.3746/JKFN.2005.34.1.008
- Han MH, Jeong JS, Jeong JW, Choi SH, Kim SO, Hong SH, Park C, Kim BW, Choi YH. Ethanol extracts of Aster yomena (Kitam.) Honda inhibit adipogenesis through the activation of the AMPK signaling pathway in 3T3-L1 preadipocytes. Drug Discov Ther 2017;11:281-7. https://doi.org/10.5582/ddt.2017.01046
- Kim MJ, Kim JH, Lee S, Cho EJ, Kim HY. Determination of radical scavenging activity of Aster yomena (Kitam.) Honda. J Korea Acad Ind Coop Soc 2018;19:402-7. https://doi.org/10.5762/KAIS.2018.19.9.402
- Kim MJ, Kim JH, Lee S, Kim HY, Cho EJ. Aster yomena (Kitam.) Honda inhibits adipocyte differentiation in 3T3-L1 cells. Int J Gerontol 2019;13:S33-8.
- Fraulob JC, Ogg-Diamantino R, Fernandes-Santos C, Aguila MB, Mandarim-de-Lacerda CA. A mouse model of metabolic syndrome: Insulin resistance, fatty liver and non-alcoholic fatty pancreas disease (NAFPD) in C57BL/6 mice fed a high fat diet. J Clin Biochem Nutr 2010;46:212-23. https://doi.org/10.3164/jcbn.09-83
- Yang Q, Qi M, Tong R, Wang D, Ding L, Li Z, Huang C, Wang Z, Yang L. Plantago asiatica L. seed extract improves lipid accumulation and hyperglycemia in high-fat diet-induced obese mice. Int J Mol Sci 2017;18:1393. https://doi.org/10.3390/ijms18071393
- Choi KM, Lee YS, Kim W, Kim SJ, Shin KO, Yu JY, Lee MK, Lee YM, Hong JT, Yun YP, et al. Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice. J Nutr Biochem 2014;25:201-7. https://doi.org/10.1016/j.jnutbio.2013.10.007
- Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502. https://doi.org/10.1093/clinchem/18.6.499
- Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-9. https://doi.org/10.1007/BF00280883
- Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care 2004;27:1487-95. https://doi.org/10.2337/diacare.27.6.1487
- Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-8. https://doi.org/10.1016/0003-2697(79)90738-3
- Hill JO, Peters JC. Environmental contributions to the obesity epidemic. Science 1998;280:1371-4. https://doi.org/10.1126/science.280.5368.1371
- Hirsch J, Batchelor B. Adipose tissue cellularity in human obesity. Clin Endocrinol Metab 1976;5:299-311. https://doi.org/10.1016/S0300-595X(76)80023-0
- Bays HE, Toth PP, Kris-Etherton PM, Abate N, Aronne LJ, Brown WV, Gonzalez-Campoy JM, Jones SR, Kumar R, La Forge R, et al. Obesity, adiposity, and dyslipidemia: a consensus statement from the National Lipid Association. J Clin Lipidol 2013;7:304-83. https://doi.org/10.1016/j.jacl.2013.04.001
- Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 2005;115:911-9. https://doi.org/10.1016/j.jaci.2005.02.023
- Shah A, Mehta N, Reilly MP. Adipose inflammation, insulin resistance, and cardiovascular disease. JPEN J Parenter Enteral Nutr 2008;32:638-44. https://doi.org/10.1177/0148607108325251
- Chandalia M, Abate N. Metabolic complications of obesity: inflated or inflamed? J Diabetes Complications 2007;21:128-36. https://doi.org/10.1016/j.jdiacomp.2006.10.004
- Pickup JC, Crook MA. Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 1998;41:1241-8. https://doi.org/10.1007/s001250051058
- Zeyda M, Stulnig TM. Obesity, inflammation, and insulin resistance--a mini-review. Gerontology 2009;55:379-86. https://doi.org/10.1159/000212758
- Kang HJ, Jeong JS, Park NJ, Go GB, Kim SO, Park C, Kim BW, Hong SH, Choi YH. An ethanol extract of Aster yomena (Kitam.) Honda inhibits lipopolysaccharide-induced inflammatory responses in murine RAW 264.7 macrophages. Biosci Trends 2017;11:85-94. https://doi.org/10.5582/bst.2016.01217
- Lee HJ, Kim HS, Seo SW. Anti-obesity effect of Aster yomena ethanol extract in high fat diet-induced obese mice. J Physiol Pathol Korean Med 2017;31:348-55. https://doi.org/10.15188/kjopp.2017.12.31.6.348
- Wieser V, Moschen AR, Tilg H. Inflammation, cytokines and insulin resistance: a clinical perspective. Arch Immunol Ther Exp (Warsz) 2013;61:119-25. https://doi.org/10.1007/s00005-012-0210-1
- Arcari DP, Bartchewsky W Jr, dos Santos TW, Oliveira KA, DeOliveira CC, Gotardo EM, Pedrazzoli J Jr, Gambero A, Ferraz LF, Carvalho PO, et al. Anti-inflammatory effects of yerba mate extract (Ilex paraguariensis) ameliorate insulin resistance in mice with high fat diet-induced obesity. Mol Cell Endocrinol 2011;335:110-5. https://doi.org/10.1016/j.mce.2011.01.003
- Hariri N, Thibault L. High-fat diet-induced obesity in animal models. Nutr Res Rev 2010;23:270-99. https://doi.org/10.1017/S0954422410000168
- Buettner R, Scholmerich J, Bollheimer LC. High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obesity (Silver Spring) 2007;15:798-808. https://doi.org/10.1038/oby.2007.608
- Woods SC, Seeley RJ, Rushing PA, D'Alessio D, Tso P. A controlled high-fat diet induces an obese syndrome in rats. J Nutr 2003;133:1081-7. https://doi.org/10.1093/jn/133.4.1081
- Lin S, Thomas TC, Storlien LH, Huang XF. Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice. Int J Obes Relat Metab Disord 2000;24:639-46. https://doi.org/10.1038/sj.ijo.0801209
- Gallou-Kabani C, Vige A, Gross MS, Rabes JP, Boileau C, Larue-Achagiotis C, Tome D, Jais JP, Junien C. C57BL/6J and A/J mice fed a high-fat diet delineate components of metabolic syndrome. Obesity (Silver Spring) 2007;15:1996-2005. https://doi.org/10.1038/oby.2007.238
- Messier C, Whately K, Liang J, Du L, Puissant D. The effects of a high-fat, high-fructose, and combination diet on learning, weight, and glucose regulation in C57BL/6 mice. Behav Brain Res 2007;178:139-45. https://doi.org/10.1016/j.bbr.2006.12.011
- Huang Y, He Y, Sun X, He Y, Li Y, Sun C. Maternal high folic acid supplement promotes glucose intolerance and insulin resistance in male mouse offspring fed a high-fat diet. Int J Mol Sci 2014;15:6298-313. https://doi.org/10.3390/ijms15046298
- Ikemoto S, Thompson KS, Takahashi M, Itakura H, Lane MD, Ezaki O. High fat diet-induced hyperglycemia: prevention by low level expression of a glucose transporter (GLUT4) minigene in transgenic mice. Proc Natl Acad Sci U S A 1995;92:3096-9. https://doi.org/10.1073/pnas.92.8.3096
- Rivellese AA, De Natale C, Lilli S. Type of dietary fat and insulin resistance. Ann N Y Acad Sci 2002;967:329-35. https://doi.org/10.1111/j.1749-6632.2002.tb04288.x
- Muniyappa R, Lee S, Chen H, Quon MJ. Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab 2008;294:E15-26. https://doi.org/10.1152/ajpendo.00645.2007
- Sundaresan A, Harini R, Pugalendi KV. Ursolic acid and rosiglitazone combination alleviates metabolic syndrome in high fat diet fed C57BL/6J mice. Gen Physiol Biophys 2012;31:323-33. https://doi.org/10.4149/gpb_2012_037
- Lelliott C, Vidal-Puig AJ. Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation. Int J Obes Relat Metab Disord 2004;28 Suppl 4:S22-8. https://doi.org/10.1038/sj.ijo.0802854
- Leonhardt M, Langhans W. Fatty acid oxidation and control of food intake. Physiol Behav 2004;83:645-51. https://doi.org/10.1016/j.physbeh.2004.07.033
- Li JZ, Ye J, Xue B, Qi J, Zhang J, Zhou Z, Li Q, Wen Z, Li P. Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation. Diabetes 2007;56:2523-32. https://doi.org/10.2337/db07-0040
- Hsu WH, Chen TH, Lee BH, Hsu YW, Pan TM. Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice. Food Chem Toxicol 2014;64:94-103. https://doi.org/10.1016/j.fct.2013.11.015
- Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 2005;310:1642-6. https://doi.org/10.1126/science.1120781
- Marin-Aguilar F, Pavillard LE, Giampieri F, Bullon P, Cordero MD. Adenosine monophosphate (AMP)-activated protein kinase: a new target for nutraceutical compounds. Int J Mol Sci 2017;18:288. https://doi.org/10.3390/ijms18020288
- Lee HA, Cho JH, Afinanisa Q, An GH, Han JG, Kang HJ, Choi SH, Seong HA. Ganoderma lucidum extract reduces insulin resistance by enhancing AMPK activation in high-fat diet-induced obese mice. Nutrients 2020;12:3338. https://doi.org/10.3390/nu12113338
- Zhao L, Zou T, Gomez NA, Wang B, Zhu MJ, Du M. Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase (AMPK) α1. Nutr Diabetes 2018;8:39. https://doi.org/10.1038/s41387-018-0049-6
- Das N, Sikder K, Ghosh S, Fromenty B, Dey S. Moringa oleifera Lam. leaf extract prevents early liver injury and restores antioxidant status in mice fed with high-fat diet. Indian J Exp Biol 2012;50:404-12. PUBMED
- Ha SK, Chae C. Inducible nitric oxide distribution in the fatty liver of a mouse with high fat diet-induced obesity. Exp Anim 2010;59:595-604. https://doi.org/10.1538/expanim.59.595
- Shyamala MP, Venukumar MR, Latha MS. Antioxidant potential of the Syzygium aromaticum (Gaertn.) Linn. (cloves) in rats fed with high fat diet. Indian J Pharmacol 2003;35:99-103.
- Noeman SA, Hamooda HE, Baalash AA. Biochemical study of oxidative stress markers in the liver, kidney and heart of high fat diet induced obesity in rats. Diabetol Metab Syndr 2011;3:17. https://doi.org/10.1186/1758-5996-3-17
- Sim JH, Lee HS, Lee S, Park DE, Oh K, Hwang KA, Kang HR, Ye SK, Kim HR. Anti-asthmatic activities of an ethanol extract of Aster yomena in an ovalbumin-induced murine asthma model. J Med Food 2014;17:606-11. https://doi.org/10.1089/jmf.2013.2939
- Amirkhizi F, Siassi F, Minaie S, Djalali M, Rahimi A, Chamari M. Is obesity associated with increased plasma lipid peroxidation and oxidative stress in women. ARYA Atheroscler 2007;2:189-92.
- Kim Y, Lee J. Esculetin, a coumarin derivative, suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes. J Funct Foods 2015;12:509-15. https://doi.org/10.1016/j.jff.2014.12.004
- Liao CC, Ou TT, Wu CH, Wang CJ. Prevention of diet-induced hyperlipidemia and obesity by caffeic acid in C57BL/6 mice through regulation of hepatic lipogenesis gene expression. J Agric Food Chem 2013;61:11082-8. https://doi.org/10.1021/jf4026647
- Jung UJ, Cho YY, Choi MS. Apigenin ameliorates dyslipidemia, hepatic steatosis and insulin resistance by modulating metabolic and transcriptional profiles in the liver of high-fat diet-induced obese mice. Nutrients 2016;8:305. https://doi.org/10.3390/nu8050305