DOI QR코드

DOI QR Code

Confirmed cases of severe fever with thrombocytopenia syndrome in companion cats with a history of tick exposure in the Republic of Korea

  • Sun-Woo, Han (Laboratory of Veterinary Internal Medicine, BK21 FOUR Future Veterinary Medicine Leading Education and Research Center, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University) ;
  • Ju-Hyun, An (Laboratory of Veterinary Internal Medicine, BK21 FOUR Future Veterinary Medicine Leading Education and Research Center, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University) ;
  • Ji-Min, Rim (Laboratory of Veterinary Internal Medicine, BK21 FOUR Future Veterinary Medicine Leading Education and Research Center, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University) ;
  • Eunseok, Jeong (Cheonan Animal Medical Center) ;
  • Sungjun, Noh (Naeum Animal Medical Center) ;
  • Myoungdai, Kang (Kang Hyounlim Animal Clinic) ;
  • Jun-Gu, Kang (Korea Zoonosis Research Institute, Jeonbuk National University) ;
  • Joon-Seok, Chae (Laboratory of Veterinary Internal Medicine, BK21 FOUR Future Veterinary Medicine Leading Education and Research Center, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University)
  • 투고 : 2022.04.11
  • 심사 : 2022.08.25
  • 발행 : 2022.11.30

초록

Severe fever with thrombocytopenia syndrome (SFTS) is a zoonotic disease, and its clinical information and prevalence are important. This study was conducted on 22 feline patients from the Republic of Korea (ROK), suspected to suffer from a tick-borne disease. Four cats were positive for SFTS, and genotypes B-1, B-3, D, and F were identified. Clinical symptoms, such as anorexia, jaundice, thrombocytopenia, leukopenia, and hyperbilirubinemia, were detected. This is the first report of SFTS virus genotypes B-1, D, and F from cats in the ROK. Moreover, our results suggest that jaundice may be an indicator of SFTS in cats.

키워드

과제정보

This research was supported by the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) through Animal Disease Management Technology Development Program, funded by the Ministry of Agriculture, Food and Rural Affairs (MAFRA) (119053-02).

참고문헌

  1. Yu XJ, Liang MF, Zhang SY, Liu Y, Li JD, Sun YL, et al. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med. 2011;364(16):1523-1532. https://doi.org/10.1056/NEJMoa1010095
  2. Kim KH, Yi J, Kim G, Choi SJ, Jun KI, Kim NH, et al. Severe fever with thrombocytopenia syndrome, South Korea, 2012. Emerg Infect Dis. 2013;19(11):1892-1894.
  3. Takahashi T, Maeda K, Suzuki T, Ishido A, Shigeoka T, Tominaga T, et al. The first identification and retrospective study of Severe Fever with Thrombocytopenia Syndrome in Japan. J Infect Dis. 2014;209(6):816-827. https://doi.org/10.1093/infdis/jit603
  4. Han SW, Kang JG, Byeon AR, Cho YK, Choi KS, Chae JS. Severe fever with thrombocytopenia syndrome in canines from the Republic of Korea. Ticks Tick Borne Dis. 2020;11(4):101454.
  5. Nam SJ, Oh YI, Kim HJ, Cheon DS, Noh SJ, Hong YJ. Unusual case of severe fever with thrombocytopenia syndrome showing clinical manifestations in a companion dog. Vet Med Sci. 2020;6(3):353-358. https://doi.org/10.1002/vms3.261
  6. Matsuu A, Momoi Y, Nishiguchi A, Noguchi K, Yabuki M, Hamakubo E, et al. Natural severe fever with thrombocytopenia syndrome virus infection in domestic cats in Japan. Vet Microbiol. 2019;236:108346.
  7. Tsuru M, Suzuki T, Murakami T, Matsui K, Maeda Y, Yoshikawa T, et al. Pathological characteristics of a patient with severe fever with thrombocytopenia syndrome (SFTS) infected with SFTS virus through a sick cat's bite. Viruses. 2021;13(2):204.
  8. Kida K, Matsuoka Y, Shimoda T, Matsuoka H, Yamada H, Saito T, et al. A case of cat-to-human transmission of severe fever with thrombocytopenia syndrome virus. Jpn J Infect Dis. 2019;72(5):356-358. https://doi.org/10.7883/yoken.JJID.2018.526
  9. Yamanaka A, Kirino Y, Fujimoto S, Ueda N, Himeji D, Miura M, et al. Direct transmission of severe fever with thrombocytopenia syndrome virus from domestic cat to veterinary personnel. Emerg Infect Dis. 2020;26(12):2994-2998. https://doi.org/10.3201/eid2612.191513
  10. Hwang J, Kang JG, Oh SS, Chae JB, Cho YK, Cho YS, et al. Molecular detection of severe fever with thrombocytopenia syndrome virus (SFTSV) in feral cats from Seoul, Korea. Ticks Tick Borne Dis. 2017;8(1):9-12. https://doi.org/10.1016/j.ttbdis.2016.08.005
  11. Kang JG, Cho YK, Han SW, Jeon K, Choi H, Kim JH, et al. Molecular and serological investigation of severe fever with thrombocytopenia syndrome virus in cats. Vector Borne Zoonotic Dis. 2020;20(12):916-920. https://doi.org/10.1089/vbz.2020.2649
  12. Kumar S, Stecher G, Tamura K. MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets. Mol Biol Evol. 2016;33(7):1870-1874. https://doi.org/10.1093/molbev/msw054
  13. Park ES, Shimojima M, Nagata N, Ami Y, Yoshikawa T, Iwata-Yoshikawa N, et al. Severe fever with thrombocytopenia syndrome phlebovirus causes lethal viral hemorrhagic fever in cats. Sci Rep. 2019;9(1):11990.
  14. Yun SM, Park SJ, Kim YI, Park SW, Yu MA, Kwon HI, et al. Genetic and pathogenic diversity of severe fever with thrombocytopenia syndrome virus (SFTSV) in South Korea. JCI Insight. 2020;5(2):e129531.
  15. Matsuno K, Nonoue N, Noda A, Kasajima N, Noguchi K, Takano A, et al. Fatal tickborne phlebovirus infection in captive cheetahs, Japan. Emerg Infect Dis. 2018;24(9):1726-1729. https://doi.org/10.3201/eid2409.171667