Animal Bioscience

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Effects of dietary supplementation of glucose oxidase, catalase, or both on reproductive performance, oxidative stress, fecal microflora and apoptosis in multiparous sows

  • Sun, Xiaojiao (Department of Animal Science, Yanbian University) ;
  • Piao, Longguo (CJ Cheiljedang feed (China) R&D center) ;
  • Jin, Haifeng (CJ Cheiljedang feed (China) R&D center) ;
  • Nogoy, K. Margarette C. (Department of Biosystems Engineering, Chungbuk National University) ;
  • Zhang, Junfang (Department of Animal Science, Yanbian University) ;
  • Sun, Bin (Department of Animal Science, Yanbian University) ;
  • Jin, Yi (Department of Animal Science, Yanbian University) ;
  • Lee, Dong Hoon (Department of Biosystems Engineering, Chungbuk National University) ;
  • Choi, Seong-Ho (Department of Animal Science, Chungbuk National University) ;
  • Smith, Stephen B (Department of Animal Science, Texas A&M University) ;
  • Li, Xiangzi (Department of Animal Science, Yanbian University)
  • Received : 2020.12.14
  • Accepted : 2021.05.24
  • Published : 2022.01.01
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Abstract

Objective: The objective of this experiment was to investigate the effect of dietary glucose oxidase (GOD), catalase (CAT), or both supplementation on reproductive performance, oxidative stress, and apoptosis in sows. Methods: A total of 104 multiparous sows were randomly assigned to four groups (n = 26) with each group given a basal diet, basal diet plus GOD at 60 U/kg, basal diet plus CAT at 75 U/kg, and basal diet plus GOD at 60 U/kg and CAT at 75 U/kg. Sows were fed the experimental diets throughout gestation and lactation. Results: Dietary GOD supplementation increased average daily feed intake of sows and litter weight at weaning (p<0.05). Dietary CAT supplementation reduced the duration of parturition, stillbirth, and piglet mortality and increased growth performance of weaned piglets (p<0.05). Dietary GOD and CAT supplementation enhanced antioxidant enzyme activities and lessened oxidative stress product levels in plasma of sows and elevated antioxidant capacity of 14-day milk and plasma in weaned piglets (p<0.05). Dietary GOD supplementation increased fecal Lactobacillus counts and reduced Escherichia coli counts of sows (p<0.05). Compared with the basal diet, the GOD diet reduced fecal Escherichia coli counts of sows, but the addition of CAT did not reduce Escherichia coli counts in the GOD diet. Dietary GOD and CAT supplementation reduced the apoptosis rate of the liver, endometrium, and ovarian granulosa cells in sows (p<0.05). In the liver, uterus, and ovary of sows, the mRNA expression of caspase-3 and caspase-9 was downregulated by dietary GOD and CAT supplementation (p<0.05). Conclusion: Dietary GOD and CAT supplementation could improve the antioxidant capacity of sows and weaned piglets, and alleviate hepatic, ovarian and uterine apoptosis by weakening apoptosis-related gene expression. Glucose oxidase regulated fecal microflora of sows, but supplementation of CAT to GOD could weaken the inhibitory effect of GOD on fecal Escherichia coli.

Keywords

Acknowledgement

The authors thank the CJ (Shenyang) Feed Co., Ltd. for animal management and technical assistance. This study was made through the grant from Engineering Research Center of North-East Cold Region Beef Cattle Science & Technology Innovation, Ministry of Education, Yanbian University, China and Chungbuk National University (2019-2020 international project), Korea.

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