Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
권호 표지
DOI QR코드

DOI QR Code

A Case of Squamous Cell Carcinoma arising from an Odontogenic Keratocyst

우측 하악의 치성 각화성 낭종 수술 후 발견된 암으로 내원한 63세 환자 1예

  • Jae Eun, Oh (Department of Otorhinolaryngology-Head & Neck Surgery, Soonchunhyang University College of Medicine) ;
  • Chan Yeong, Lee (Department of Plastic Surgery, Soonchunhyang University College of Medicine) ;
  • Kyeong Min, Kim (Department of Pathology, Soonchunhyang University College of Medicine) ;
  • Min Sung, Tak (Department of Plastic Surgery, Soonchunhyang University College of Medicine) ;
  • Hyung Kwon, Byeon (Department of Otorhinolaryngology-Head & Neck Surger, Soonchunhyang University College of Medicine)
  • 오재은 (순천향대학교 서울병원 이비인후과학교실) ;
  • 이찬영 (순천향대학교 서울병원 성형외과학교실) ;
  • 김경민 (순천향대학교 서울병원 병리과교실) ;
  • 탁민성 (순천향대학교 서울병원 성형외과학교실) ;
  • 변형권 (순천향대학교 서울병원 이비인후과학교실)
  • Received : 2022.11.04
  • Accepted : 2022.11.13
  • Published : 2022.11.30
Download PDF
⟨ Previous Next ⟩

Abstract

Odontogenic keratocyst (OKC) accounts for 3-11% of all odontogenic cysts. OKC is a benign intra-osseous odontogenic tumor, but what makes this cyst special is its aggressive behavior and high recurrence rate. OKC is relatively aggressive compared to other odontogenic cysts, but its malignant transformation is considered extremely rare. Squamous cell carcinoma associated with odontogenic keratocysts have rarely been reported in the medical literature. We recently experienced a case of a 63-year-old man finally confirmed with squamous cell carcinoma of the mandible, which was initially diagnosed as a benign odontogenic keratocyst. Surgical resection was performed as definitive treatment. Therefore, we present this unique case with a review of the literature.

Keywords

References

  1. Chirapathomsakul D, Sastravaha P, Jansisyanont P. A review of odontogenic keratocysts and the behavior of recurrences. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:5-9. https://doi.org/10.1016/j.tripleo.2005.03.023
  2. Lee JM, Park JH, Kim KC, Choi SC. Odontogenic keratocyst of a female child, a case report. J Korean Acad Pediatr Dent. 2008; 35:731-736.
  3. Tamgadge S, Tamgadge A, Modak N, Bhalerao S. Primary intraosseous squamous cell carcinoma arising from an odontogenic keratocyst: A case report and literature review. Ecancermedicalscience. 2013;7:316.
  4. Woolgar JA, Triantafyllou A, Ferlito A, Devaney KO, Lewis JS, Jr., Rinaldo A, et al. Intraosseous carcinoma of the jaws--a clinicopathologic review. Part I: Metastatic and salivary-type carcinomas. Head Neck. 2013;35:895-901. https://doi.org/10.1002/hed.22917
  5. Woolgar JA, Triantafyllou A, Ferlito A, Devaney KO, Lewis JS, Jr., Rinaldo A, et al. Intraosseous carcinoma of the jaws: A clinicopathologic review. Part III: Primary intraosseous squamous cell carcinoma. Head Neck. 2013;35:906-909. https://doi.org/10.1002/hed.22922
  6. Bataineh AB, al Qudah M. Treatment of mandibular odontogenic keratocysts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;86:42-47. https://doi.org/10.1016/S1079-2104(98)90148-2
  7. Payne TF. An analysis of the clinical and histopathologic parameters of the odontogenic keratocyst. Oral Surg Oral Med Oral Pathol. 1972;33:538-546. https://doi.org/10.1016/0030-4220(72)90366-0
  8. Kinard B, Hansen G, Newman M, Dennis P, Haeffs T, Perez S, et al. How well do we manage the odontogenic keratocyst? A multicenter study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2019;127:282-288. https://doi.org/10.1016/j.oooo.2018.12.001
  9. van der Wal KG, de Visscher JG, Eggink HF. Squamous cell carcinoma arising in a residual cyst. A case report. Int J Oral Maxillofac Surg. 1993;22:350-352. https://doi.org/10.1016/S0901-5027(05)80665-4
  10. Gardner AF. The odontogenic cyst as a potential carcinoma: A clinicopathologic appraisal. J Am Dent Assoc. 1969;78:746-755. https://doi.org/10.14219/jada.archive.1969.0290
  11. Yu J-J, Hwang E-H, Lee S-R, Choi J-H. Squamous cell carcinoma arising in an odontogenic cyst. Imaging Sci Dent. 2003;33:235-238.
  12. Ye P, Wei T, Gao Y, Zhang W, Peng X. Primary intraosseous squamous cell carcinoma arising from an odontogenic keratocyst: case series and literature review. Med Oral Patol Oral Cir Bucal. 2021;26:e49-e55.
  13. Monteiro L, Santiago C, Amaral BD, Al-Mossallami A, Albuquerque R, Lopes C. An observational retrospective study of odontogenic cyst's and tumours over an 18-year period in a Portuguese population according to the new WHO Head and Neck Tumour classification. Med Oral Patol Oral Cir Bucal. 2021;26:e482-e493.
  14. Chen P, Liu B, Wei B, Yu S. The clinicopathological features and treatments of odontogenic keratocysts. Am J Cancer Res. 2022;12:3479-3485.
  15. Elzay RP. Primary intraosseous carcinoma of the jaws. Review and update of odontogenic carcinomas. Oral Surg Oral Med Oral Pathol. 1982;54:299-303. https://doi.org/10.1016/0030-4220(82)90099-8