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The Korean Society of Phycology (한국조류학회(藻類))
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Polyphenol-rich Sargassum horneri alleviates atopic dermatitis-like skin lesions in NC/Nga mice by suppressing Th2-mediated cytokine IL-13

  • Suyama Prasansali, Mihindukulasooriya (Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University) ;
  • Hyo Jin, Kim (Department of Food Bioengineering, Jeju National University) ;
  • Jinhee, Cho (Department of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Kalahe Hewage Iresha Nadeeka Madushani, Herath (Department of Biosystems Engineering, Faculty of Agriculture and Plantation Managements, Wayamba University) ;
  • Jiwon, Yang (Animal Biotechnology, Jeju National University) ;
  • Duong Thi Thuy, Dinh (Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University) ;
  • Mi-Ok, Ko (Department of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • You-Jin, Jeon (Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University) ;
  • Ginnae, Ahn (Department of Food Technology and Nutrition, Chonnam National University) ;
  • Youngheun, Jee (Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University)
  • Received : 2022.08.24
  • Accepted : 2022.11.24
  • Published : 2022.12.15
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Abstract

Atopic dermatitis (AD) is one of major skin inflammatory diseases characterized by excessive Th2-mediated immune responses. Recent evidence provides that interlukin-13 (IL-13) plays the role of a key Th2 cytokine that drives the inflammation underlining AD. Due to adverse effects of commercially available synthetic drugs, the need for treatments based on natural products is gaining much attention. Sargassum horneri is an edible brown algae known for beneficial bioactivities including anti-inflammation. We investigated if polyphenol-rich S. horneri extracts (SHE) could suppress AD-like skin lesions in NC/Nga mice and if that involved inhibition of the infiltration of Th2-mediated cytokine IL-13. We observed markedly increased infiltration of IL-13 positive cells in AD-like skin lesions of mice but SHE treatments decreased it. Also, the dermal expression of IL-13 was sufficient to cause inflammatory responses in mice skin resembling human AD. SHE suppressed the dermal infiltration of inflammatory cells where IL-13 plays a crucial role in skin tissues and in the recruitment of inflammatory cells. Furthermore, it was confirmed that SHE reduced T cell, dendritic cell, and macrophage populations in spleen. Moreover, SHE decreased the collagen deposition in skin and ear dermis resulting in reduced fibrosis that occurs in AD due to excessive collagen. Taken together, our results reveal that SHE suppressed the infiltration of inflammatory cells into skin dermis by decreasing the infiltration of IL-13 positive cells. Therefore, SHE could be taken as a useful therapeutic agent to alleviate AD.

Keywords

Acknowledgement

This research was supported by the research grant of Jeju National University in 2022. We would like to thank Dr. T. H. Chung for editorial assistance.

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