Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Comparison of Analysis Results According to Heterogeneous or Homogeneous Model for CT-based Focused Ultrasound Simulation

CT 영상 기반 집속 초음파 시뮬레이션 모델의 불균질 물성과 균질 물성에 따른 모델 분석 결과 비교

  • Hyeon, Seo (Department of Computer Science, Gyeongsang National University) ;
  • Eun-Hee, Lee (Medical Device Development Center, Daegu Gyeongbuk Medical Innovation Foundation)
  • 서현 (경상국립대학교 컴퓨터과학부 컴퓨터과학전공) ;
  • 이은희 (대구경북첨단의료산업진흥재단 첨단의료기기개발지원센터)
  • Received : 2022.10.05
  • Accepted : 2022.11.10
  • Published : 2022.12.31
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Abstract

Purpose: Focused ultrasound is an emerging technology for treating the brain locally in a noninvasive manner. In this study, we have investigated the influence of skull properties on simulating transcranial pressure field. Methods: A 3D computational model of transcranial focused ultrasound was constructed using female and male CT data to solve for intracranial pressure. For heterogeneous model, the acoustic properties were calculated from CT Hounsfield units based on a porosity. The homogeneous model assigned constant acoustic properties for the single-layered skull. Results: A computational model was validated against empirical data. The homogeneous models were then compared with the heterogeneous model, resulted in 10.87% and 7.19% differences in peak pressure for female and male models respectively. For the focal volume, homogeneous model demonstrated more than 94% overlap compared with the heterogeneous model. Conclusion: Homogeneous model can be constructed using MR images that are commonly used for the segmentation of the skull. We propose the possibility of the homogeneous model for the simulating transcranial pressure field owing to comparable focal volume between homogeneous model and heterogeneous model.

Keywords

Acknowledgement

본 연구는 교육부의 재원으로 한국연구재단의 지원을 받아 수행된 지자체-대학 협력기반지역혁신 사업(과제관리번호: 2021RIS-003)과 보건복지부 및 과학기술정보통신부의 재원으로 한국보건산업진흥원의 보건의료기술연구개발사업(과제관리번호: HU21C0081) 지원을 받아 수행하였음.

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