DOI QR코드

DOI QR Code

Changing prevalence of Helicobacter pylori infection in children and adolescents

  • Park, Ji Sook (Department of Pediatrics, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine) ;
  • Jun, Jin Su (Department of Pediatrics, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine) ;
  • Seo, Ji-Hyun (Department of Pediatrics, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine) ;
  • Youn, Hee-Shang (Department of Pediatrics, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine) ;
  • Rhee, Kwang-Ho (Institute of Health Sciences, Gyeongsang National University)
  • Received : 2019.12.10
  • Accepted : 2020.02.14
  • Published : 2021.01.15

Abstract

Helicobacter pylori infection has declined over recent decades. However, its prevalence remains high, and nearly 50% of the global population has been infected. In Korea, seroprevalence has steadily decreased in adults, but the status of H. pylori infection in children is unknown. The current status or trend of H. pylori infection in children is important because it can help estimate H. pylori-related diseases including gastric cancer in later life. In this review, the authors discuss the change in H. pylori infection rate among children and adolescents based on literature reviews and our research.

Keywords

Acknowledgement

This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2013R1A1A2057513). The authors declare no conflicts of interest.

References

  1. Eusebi LH, Zagari RM, Bazzoli F. Epidemiology of Helicobacter pylori infection. Helicobacter 2014;19 Suppl 1:1-5. https://doi.org/10.1111/hel.12165
  2. Zabala Torrres B, Lucero Y, Lagomarcino AJ, Orellana-Manzano A, George S, Torres JP, et al. Review: prevalence and dynamics of Helicobacter pylori infection during childhood. Helicobacter. 2017;22.
  3. Lim SH, Kwon JW, Kim N, Kim GH, Kang JM, Park MJ, et al. Prevalence and risk factors of Helicobacter pylori infection in Korea: nationwide multicenter study over 13 years. BMC Gastroenterol 2013;13:104. https://doi.org/10.1186/1471-230X-13-104
  4. Rhee KH, Youn HS, Baik SC, Lee WK, Cho MJ, Choi HJ, et al. Prevalence of Helicobacter pylori infection in Korea. J Korean Soc Microbiol 1990;25:475-90.
  5. O'Ryan ML, Rabello M, Cortes H, Lucero Y, Pena A, Torres JP. Dynamics of Helicobacter pylori detection in stools during the first 5 years of life in Chile, a rapidly developing country. Pediatr Infect Dis J 2013;32:99-103. https://doi.org/10.1097/INF.0b013e318278b929
  6. Seo JH, Youn JH, Kim EA, Jun JS, Park JS, Yeom JS, et al. Helicobacter pylori antigens inducing early immune response in infants. J Korean Med Sci 2017;32:1139-46. https://doi.org/10.3346/jkms.2017.32.7.1139
  7. Correa P, Piazuelo MB. Natural history of Helicobacter pylori infection. Dig Liver Dis 2008;40:490-6. https://doi.org/10.1016/j.dld.2008.02.035
  8. Seo JH, Park JS, Rhee KH, Youn HS. Diagnosis of Helicobacter pylori infection in children and adolescents in Korea. Pediatr Gastroenterol Hepatol Nutr 2018;21:219-33. https://doi.org/10.5223/pghn.2018.21.4.219
  9. Lee SY, Ko JS, Seo JK. Changes in the prevalence of biopsy-proven Helicobacter pylori infection in Korean children with functional recurrent abdominal pain over the last 18 years. Korean J Pediatr Gastroenterol Nutr 2009;12:150-5. https://doi.org/10.5223/kjpgn.2009.12.2.150
  10. Malaty HM, Kim JG, Kim SD, Graham DY. Prevalence of Helicobacter pylori infection in Korean children: inverse relation to socioeconomic status despite a uniformly high prevalence in adults. Am J Epidemiol 1996;143:257-62. https://doi.org/10.1093/oxfordjournals.aje.a008736
  11. Jang KM, Choe BH, Choe JY, Hong SJ, Park HJ, Chu MA, et al. Changing prevalence of helicobacter pylori infections in Korean children with recurrent abdominal pain. Pediatr Gastroenterol Hepatol Nutr 2015;18:10-6. https://doi.org/10.5223/pghn.2015.18.1.10
  12. Yang HR. Updates on the diagnosis of Helicobacter pylori infection in children: what are the differences between adults and children? Pediatr Gastroenterol Hepatol Nutr 2016;19:96-103. https://doi.org/10.5223/pghn.2016.19.2.96
  13. Seo JH, Park JS, Yeom JS, Lim JY, Park CH, Woo HO, et al. Correlation between positive rate and number of biopsy samples on urease test in childhood Helicobacter pylori infection. J Korean Med Sci 2014;29:106-9. https://doi.org/10.3346/jkms.2014.29.1.106
  14. Lim SH, Kim N, Kwon JW, Kim SE, Baik GH, Lee JY, et al. Trends in the seroprevalence of Helicobacter pylori infection and its putative eradication rate over 18 years in Korea: a cross-sectional nationwide multicenter study. PLoS One 2018;13:e0204762. https://doi.org/10.1371/journal.pone.0204762
  15. Urita Y, Watanabe T, Kawagoe N, Takemoto I, Tanaka H, Kijima S, et al. Role of infected grandmothers in transmission of Helicobacter pylori to children in a Japanese rural town. J Paediatr Child Health 2013;49:394-8. https://doi.org/10.1111/jpc.12191
  16. Michel A, Pawlita M, Boeing H, Gissmann L, Waterboer T. Helicobacter pylori antibody patterns in Germany: a cross-sectional population study. Gut Pathog 2014;6:10. https://doi.org/10.1186/1757-4749-6-10
  17. den Hollander WJ, Holster IL, van Gilst B, van Vuuren AJ, Jaddoe VW, Hofman A, et al. Intergenerational reduction in Helicobacter pylori prevalence is similar between different ethnic groups living in a Western city. Gut 2015;64:1200-8. https://doi.org/10.1136/gutjnl-2014-307689
  18. Patterson T, Straten E, Jimenez S. The prevalence of Helicobacter pylori antibody in different age groups in Central Texas. Clin Lab Sci 2012;25:102-6. https://doi.org/10.29074/ascls.25.2.102
  19. Muhsen K, Lagos R, Reymann MK, Graham DY, Pasetti MF, Levine MM. Age-dependent association among Helicobacter pylori infection, serum pepsinogen levels and immune response of children to live oral cholera vaccine CVD 103-HgR. PLoS One 2014;9:e83999. https://doi.org/10.1371/journal.pone.0083999
  20. Fuenmayor-Boscan AD, Hernandez IM, Valero KJ, Paz AM, Sandrea LB, Rivero Z. Association between Helicobacter pylori and intestinal parasites in an Anu indigenous community of Venezuela. Indian J Gastroenterol 2016;35:106-12. https://doi.org/10.1007/s12664-016-0641-4
  21. Ghasemi-Kebria F, Ghaemi E, Azadfar S, Roshandel G. Epidemiology of Helicobacter pylori infection among Iranian children. Arab J Gastroenterol 2013;14:169-72. https://doi.org/10.1016/j.ajg.2013.11.002
  22. Senbanjo IO, Oshikoya KA, Njokanma OF. Helicobacter pylori associated with breastfeeding, nutritional status and recurrent abdominal pain in healthy Nigerian children. J Infect Dev Ctries 2014;8:448-53. https://doi.org/10.3855/jidc.3196
  23. Oleastro M, Pelerito A, Nogueira P, Benoliel J, Santos A, Cabral J, et al. Prevalence and incidence of Helicobacter pylori Infection in a healthy pediatric population in the Lisbon area. Helicobacter 2011;16:363-72. https://doi.org/10.1111/j.1523-5378.2011.00858.x
  24. Serrano CA, Talesnik E, Pena A, Rollan A, Duarte I, Torres J, et al. Inverse correlation between allergy markers and Helicobacter pylori infection in children is associated with elevated levels of TGF-β. Eur J Gastroenterol Hepatol 2011;23:656-63. https://doi.org/10.1097/MEG.0b013e328347c231
  25. Parzecka M, Szaflarska-Poplawska A, Gasiorowska J, Gorzkiewicz M, Grzybowski T. The prevalence of dupA (duodenal ulcer-promoting gene) of Helicobacter pylori in children and adolescents: own observation. Pol Merkur Lekarski 2013;34:277-80.
  26. Gijsbers CF, Benninga M, Buller H. Clinical and laboratory findings in 220 children with recurrent abdominal pain. Acta Paediatr 2011;100:1028-32. https://doi.org/10.1111/j.1651-2227.2011.02179.x
  27. Elitsur Y, Alrazzak BA, Preston D, Demetieva Y. Does Helicobacter pylori protect against eosinophilic esophagitis in children? Helicobacter 2014;19:367-71. https://doi.org/10.1111/hel.12129
  28. Youn HS, Baik SC, Cho YK, Woo HO, Ahn YO, Kim K, et al. Comparison of Helicobacter pylori infection between Fukuoka, Japan and Chinju, Korea. Helicobacter 1998;3:9-14. https://doi.org/10.1046/j.1523-5378.1998.08011.x
  29. Okuda M, Osaki T, Lin Y, Yonezawa H, Maekawa K, Kamiya S, et al. Low prevalence and incidence of Helicobacter pylori infection in children: a population-based study in Japan. Helicobacter 2015;20:133-8. https://doi.org/10.1111/hel.12184
  30. Den Hollander WJ, Holster IL, den Hoed CM, van Deurzen F, van Vuuren AJ, Jaddoe VW, et al. Ethnicity is a strong predictor for Helicobacter pylori infection in young women in a multi-ethnic European city. J Gastroenterol Hepatol 2013;28:1705-11. https://doi.org/10.1111/jgh.12315
  31. Ozaydin N, Turkyilmaz SA, Cali S. Prevalence and risk factors of Helicobacter pylori in Turkey: a nationally-representative, cross-sectional, screening with the 13C-Urea breath test. BMC Public Health 2013;13:1215. https://doi.org/10.1186/1471-2458-13-1215
  32. Kivi M, Tindberg Y, Sorberg M, Casswall TH, Befrits R, Hellstrom PM, et al. Concordance of Helicobacter pylori strains within families. J Clin Microbiol 2003;41:5604-8. https://doi.org/10.1128/JCM.41.12.5604-5608.2003
  33. Cho MJ, Lee WK, Jeon YS, Kim KH, Kim SH, Baik SC, et al. Intrafamilial transmission of Helicobacter pylori detected by random amplified polymorphic DNA fingerprinting. Mol Cells 1995;5:508-13.
  34. Benajah DA, Lahbabi M, Alaoui S, El Rhazi K, El Abkari M, Nejjari C, et al. Prevalence of Helicobacter pylori and its recurrence after successful eradication in a developing nation (Morocco). Clin Res Hepatol Gastroenterol 2013;37:519-26. https://doi.org/10.1016/j.clinre.2013.02.003
  35. Mathewos B, Moges B, Dagnew M. Seroprevalence and trend of Helicobacter pylori infection in Gondar University Hospital among dyspeptic patients, Gondar, North West Ethiopia. BMC Res Notes 2013;6:346. https://doi.org/10.1186/1756-0500-6-346
  36. Kim MS, Kim N, Kim SE, Jo HJ, Shin CM, Lee SH, et al. Long-term follow-up Helicobacter pylori reinfection rate and its associated factors in Korea. Helicobacter 2013;18:135-42. https://doi.org/10.1111/hel.12018
  37. Yan TL, Hu QD, Zhang Q, Li YM, Liang TB. National rates of Helicobacter pylori recurrence are significantly and inversely correlated with human development index. Aliment Pharmacol Ther 2013;37:963-8. https://doi.org/10.1111/apt.12293
  38. Jun JS, Seo JH, Park JS, Rhee KH, Youn HS. Changes in the treatment strategies for Helicobacter pylori infection in children and adolescents in Korea. Pediatr Gastroenterol Hepatol Nutr 2019;22:417-30. https://doi.org/10.5223/pghn.2019.22.5.417

Cited by

  1. Regular arrangement of collecting venules (RAC) as an endoscopic marker for exclusion of Helicobacter pylori (H. pylori) infection: A systematic review and meta‐analysis vol.75, pp.11, 2021, https://doi.org/10.1111/ijcp.14548
  2. Persistent Helicobacter pylori infection for more than 3 years leads to elevated serum homocysteine concentration: A retrospective cohort study based on a healthy Chinese population vol.36, pp.11, 2021, https://doi.org/10.1111/jgh.15603
  3. Does Alzheimer's disease stem in the gastrointestinal system? vol.287, 2021, https://doi.org/10.1016/j.lfs.2021.120088