Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
권호 표지
DOI QR코드

DOI QR Code

Association between small for gestational age and risk of autism spectrum disorders: a meta-analysis

  • Jenabi, Ensiyeh (Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences) ;
  • Bashirian, Saeid (Social Determinants of Health Research Center, Hamadan University of Medical Sciences) ;
  • Asali, Zahra (Department of Midwifery, Tuyserkan Branch, Islamic Azad University) ;
  • Seyedi, Mahdieh (Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences)
  • 투고 : 2020.12.03
  • 심사 : 2021.01.16
  • 발행 : 2021.10.15
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Background: The relationship between small for gestational age (SGA) and autism spectrum disorders (ASDs) remains unknown. Purpose: This meta-analysis aimed to investigate the relationship between SGA and the risk of ASD. Methods: We searched PubMed, Web of Science, and Scopus databases from inception to November 2020. The heterogeneity across studies was explored using the I2 statistic. The possibility of publication bias was assessed using Begg test. The results were reported using the odds ratio (OR) and 95% confidence interval (CI) using a random-effects model. Results: The literature search yielded 824 articles with 8,752,138 participants. We assessed the association between SGA and the risk of ASD in cohort and case-control studies. Based on the random-effects model, compared with SGA, the estimated OR of the risk of ASD was 1.17 (95% CI, 1.09-1.24). Therefore, there was a significant association between SGA and the risk of ASD. Conclusion: Based on OR reports in epidemiological studies, we showed that SGA is a risk factor for and can increase the risk of ASD. The association between SGA and ASD risk has further relevance to the current public health emphasis on appropriate prepregnancy weight and pregnancy weight gain.

키워드

과제정보

This study was financially supported by Hamadan university of Medical Sciences with code: 9910167203.

참고문헌

  1. Moore GS, Kneitel AW, Walker CK, Gilbert WM, Xing G. Autism risk in small-and large-for-gestational-age infants. Am J Obstet Gynecol 2012;206:314.e1-9. https://doi.org/10.1016/j.ajog.2012.01.044
  2. Modabbernia A, Velthorst E, Reichenberg A. Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses. Mol Autism 2017;8:13. https://doi.org/10.1186/s13229-017-0121-4
  3. Gardener H, Spiegelman D, Buka SL. Perinatal and neonatal risk factors for autism: a comprehensive meta-analysis. Pediatrics 2011;128:344-55. https://doi.org/10.1542/peds.2010-1036
  4. Newschaffer CJ, Fallin D, Lee NL. Heritable and nonheritable risk factors for autism spectrum disorders. Epidemiol Rev 2002;24:137-53. https://doi.org/10.1093/epirev/mxf010
  5. Brumbaugh JE, Weaver AL, Myers SM, Voigt RG, Katusic SK. Gestational age, perinatal characteristics, and autism spectrum disorder: a birth cohort study. J Pediatr 2020;220:175-83.e8. https://doi.org/10.1016/j.jpeds.2020.01.022
  6. Jenabi E, Karami M, Khazaei S, Bashirian S. The association between preeclampsia and autism spectrum disorders among children: a meta-analysis. Korean J Pediatr 2019;62:126-30. https://doi.org/10.3345/kjp.2018.07010
  7. Jenabi E, Bashirian S, Khazaei S. Association between neonatal jaundice and autism spectrum disorders among children: a meta-analysis. Clin Exp Pediatr 2020;63:8-13. https://doi.org/10.3345/kjp.2019.00815
  8. Jenabi E, Seyedi M, Hamzehei R, Bashirian S, Rezaei M, Razjouyan K, et al. The association between assisted reproductive technology and autism spectrum disorders in Iran: a case-control study. Clin Exp Pediatr 2020;63:368-72. https://doi.org/10.3345/cep.2020.00073
  9. Maimburg RD, Vaeth M. Perinatal risk factors and infantile autism. Acta Psychiatr Scand 2006;114:257-64. https://doi.org/10.1111/j.1600-0447.2006.00805.x
  10. Vinet E, Pineau CA, Clarke AE, Scott S, Fombonne E, Joseph L, et al. Increased risk of autism spectrum disorders in children born to women with systemic lupus erythematosus: results from a large population-based cohort. Arthritis Rheumatol 2015;67:3201-8. https://doi.org/10.1002/art.39320
  11. Kaddah FAA, Nassar JF, Ghandour HH, El-Farghali OG. Screening for autism in low-birth-weight Egyptian toddlers. Egypt J Otolaryngol 2013;29:38-45
  12. Lampi KM, Lehtonen L, Tran PL, Suominen A, Lehti V, Banerjee PN, et al. Risk of autism spectrum disorders in low birth weight and small for gestational age infants. J Pediatr 2012;161:830-6. https://doi.org/10.1016/j.jpeds.2012.04.058
  13. Larsson HJ, Eaton WW, Madsen KM, Vestergaard M, Olesen AV, Agerbo E, et al. Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status. Am J Epidemiol 2005;161:916-25. https://doi.org/10.1093/aje/kwi123
  14. Buchmayer S, Johansson S, Johansson A, Hultman CM, Sparen P, Cnattingius S. Can association between preterm birth and autism be explained by maternal or neonatal morbidity? Pediatrics 2009;124:e817-25. https://doi.org/10.1542/peds.2008-3582
  15. Haglund NG, Kallen KB. Risk factors for autism and Asperger syndrome: perinatal factors and migration. Autism 2011;15:163-83. https://doi.org/10.1177/1362361309353614
  16. Joseph RM, O'Shea TM, Allred EN, Heeren T, Hirtz D, Paneth N, et al. Prevalence and associated features of autism spectrum disorder in extremely low gestational age newborns at age 10 years. Autism Res 2017;10:224-32. https://doi.org/10.1002/aur.1644
  17. Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses [Internet]. Ottawa (ON): Ottawa Hospital Research Institute; 2009 [cited 2020 Nov 5]. Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
  18. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions Version 5.0.0 [Internet]. London: The Cochrane Collaboration; 2008 [updated 2008 Feb; cited 2020 Nov 5]. Available from: www.cochrane-handbook.org.
  19. Higgins JPT, Thompson SG, Deeks JJ, Altman D. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-60. https://doi.org/10.1136/bmj.327.7414.557
  20. Egger M, Davey SG, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-34. https://doi.org/10.1136/bmj.315.7109.629
  21. Dodds L, Fell DB, Shea S, Armson BA, Allen AC, Bryson S. The role of prenatal, obstetric and neonatal factors in the development of autism. Rev J Autism Dev Disord 2011;41:891-902. https://doi.org/10.1007/s10803-010-1114-8
  22. Kuzniewicz MW, Wi S, Qian Y, Walsh EM, Armstrong MA, Croen LA. Prevalence and neonatal factors associated with autism spectrum disorders in preterm infants. J Pediatr 2014;164:20-5. https://doi.org/10.1016/j.jpeds.2013.09.021
  23. Quinlan CA, McVeigh KH, Driver CR, Govind P, Karpati A. Parental age and autism spectrum disorders among New York city children 0-36 months of age. Matern Child Health J 2015;19:1783-90. https://doi.org/10.1007/s10995-015-1692-3
  24. Schieve LA, Tian LH, Baio J, Rankin K, Rosenberg D, Wiggins L, et al. Population attributable fractions for three perinatal risk factors for autism spectrum disorders, 2002 and 2008 autism and developmental disabilities monitoring network. Ann Epidemiol 2014;24:260-6. https://doi.org/10.1016/j.annepidem.2013.12.014
  25. Sujan AC, Rickert ME, Oberg AS, Quinn PD, Hernandez-Diaz S, Almqvist C, et al. Associations of maternal antidepressant use during the first trimester of pregnancy with preterm birth, small for gestational age, autism spectrum disorder, and attention-deficit/hyperactivity disorder in offspring. JAMA 2017;317:1553-62. https://doi.org/10.1001/jama.2017.3413
  26. Davidovitch M, Kuint J, Lerner-Geva L, Zaslavsky-Paltiel I, Rotem RS, Chodick G, et al. Postnatal steroid therapy is associated with autism spectrum disorder in children and adolescents of very low birth weight infants. Pediatr Res 2020;87:1045-51. https://doi.org/10.1038/s41390-019-0700-5
  27. Hultman CM, Sparen P, Cnattingius S. Perinatal risk factors for infantile autism. Epidemiology 2002;13:417-23. https://doi.org/10.1097/00001648-200207000-00009
  28. Maia FA, Oliveira LMM, Almeida MTC, Alves MR, Saeger VSdA, Silva VBd, et al. Autism spectrum disorder and postnatal factors: a case-control study in brazil. Rev Paul Pediatr 2019;37:398-405. https://doi.org/10.1590/1984-0462/;2019;37;4;00006
  29. Hussain K, Dunne MJ. Hypoglycemia. In: Brook CGD, Clayton PE, Brown RS. Brook's clinical pediatric endocrinology. Malden (MA): Blackwell Pub; 2005. p. 474.
  30. Ekblad M, Gissler M, Lehtonen L, Korkeila J. Prenatal smoking exposure and the risk of psychiatric morbidity into young adulthood. Arch Gen Psychiatry 2010;67:841-9. https://doi.org/10.1001/archgenpsychiatry.2010.92
  31. Kelly RH, Russo J, Holt VL, Danielsen BH, Zatzick DF, Walker E, et al. Psychiatric and substance use disorders as risk factors for low birth weight and preterm delivery. Obstet Gynaecol 2002;100:297-304.