Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Is there an association between labor induction and attention-deficit/hyperactivity disorder among children?

  • Jenabi, Ensiyeh (Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences) ;
  • Seyedi, Mahdieh (Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences) ;
  • Bashirian, Saeid (Social Determinants of Health Research Center, Hamadan University of Medical Sciences) ;
  • Fereidooni, Bita (Midwife in Social Security Organization)
  • Received : 2020.09.13
  • Accepted : 2021.01.12
  • Published : 2021.09.15
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Abstract

Background: There is evidence of destructive effects of oxytocin use during labor on neurodevelopment. Purpose: This meta-analysis pooled all observational studies to determine the association between labor induction and the risk of attention-deficit/hyperactivity disorder (ADHD) among children. Methods: All observational studies (case-control and cohort) were reviewed until September 2020 after searches of the PubMed, Scopus, and Web of Science databases, the gray literature, and conference proceedings. The pooled odds ratios (ORs), relative ratios (RRs), and 95% confidence intervals (CI (swere calculated as random effect estimates of association among studies. Results: All observational studies were reviewed, including 4 cohort studies including 2,885,743 participants and 3 case-control studies including 51,135 participants (10,961 with ADHD and 40,174 in control groups) with a sample size of 2,936,878 participants. The pooled estimates of OR and RR did not indicate a significant association between labor induction and ADHD among children (OR, 1.13; 95% CI, 0.90-1.35) and (RR, 1.10; 95% CI, 0.96-1.24). Conclusions: The findings showed that labor induction is not associated with an increased risk of ADHD among children. However, more studies are needed to investigate the relationship between labor induction and ADHD.

Keywords

Acknowledgement

This study was supported by Hamadan University of Medical Sciences (9907084773 and ethical committee code IR.UMSHA.REC.1399.526).

References

  1. Polanczyk GV, Salum GA, Sugaya LS, Caye A, Rohde LA. Annual research review: a meta-analysis of the worldwide prevalence of mental disorders in children and adolescents. J Child Psychol Psychiatry 2015;56:345-65. https://doi.org/10.1111/jcpp.12381
  2. Doshi JA, Hodgkins P, Kahle J, Sikirica V, Cangelosi MJ, Setyawan J, et al. Economic impact of childhood and adult attention-deficit/hyperactivity disorder in the United States. J Am Acad Child Adolesc Psychiatry 2012; 51:990-1002.e2. https://doi.org/10.1016/j.jaac.2012.07.008
  3. Sucksdorff M, Lehtonen L, Chudal R, Suominen A, Joelsson P, Gissler M, et al. Preterm birth and poor fetal growth as risk factors of attention-deficit/hyperactivity disorder. Pediatrics 2015;136:e599-608. https://doi.org/10.1542/peds.2015-1043
  4. Sucksdorff M, Lehtonen L, Chudal R, Suominen A, Gissler M, Sourander A. Lower Apgar scores and Caesarean sections are related to attention-deficit/hyperactivity disorder. Acta Paediatr 2018;107:1750-8. https://doi.org/10.1111/apa.14349
  5. Jenabi E, Bashirian S, Khazaei S, Basiri Z. The maternal prepregnancy body mass index and the risk of attention deficit hyperactivity disorder among children and adolescents: a systematic review and meta-analysis. Korean J Pediatr 2019;62:374. https://doi.org/10.3345/kjp.2019.00185
  6. Oscarsson ME, Amer-Wahlin I, Rydhstroem H, Kallen K. Outcome in obstetric care related to oxytocin use. A population-based study. Acta Obstet Gynecol Scand 2006;85:1094-8. https://doi.org/10.1080/00016340600804530
  7. Wahl RUR. Could oxytocin administration during labor contribute to autism and related behavioral disorders?-A look at the literature. Med Hypotheses 2004;63:456-60. https://doi.org/10.1016/j.mehy.2004.03.008
  8. Kurth L. Birthing the ADHD generation? Exploring the association between prenatal Pitocin® exposure and childhood ADHD onset. ADHD Rep 2012;20:7-9,15-6. https://doi.org/10.1521/adhd.2012.20.1.7
  9. Henriksen L, Wu CS, Secher NJ, Obel C, Juhl M. Medical augmentation of labor and the risk of ADHD in offspring: a population-based study. Pediatrics 2015;135:e672-7. https://doi.org/10.1542/peds.2014-1542
  10. Silva D, Colvin L, Hagemann E, Bower C. Environmental risk factors by gender associated with attention-deficit/hyperactivity disorder. Pediatrics 2014;133:e14-22. https://doi.org/10.1542/peds.2013-1434
  11. Lonfeldt NN, Verhulst FC, Strandberg-Larsen K, Plessen KJ, Lebowitz ER. Assessing risk of neurodevelopmental disorders after birth with oxytocin: a systematic review and meta-analysis. Psychol Med 2019;49: 881-90. https://doi.org/10.1017/s0033291718003021
  12. Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses [Internet]. Ottawa Hospital Research Institute; 2009 Sep 15 [cited 2014 Mar 25]. Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp.
  13. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-34. https://doi.org/10.1136/bmj.315.7109.629
  14. Curran EA, Cryan JF, Kenny LC, Dinan TG, Kearney PM, Khashan AS. Obstetrical mode of delivery and childhood behavior and psychological development in a British cohort. J Autism Dev Disord 2016;46:603-14. https://doi.org/10.1007/s10803-015-2616-1
  15. Stokholm L, Juhl M, Talge NM, Gissler M, Obel C, Strandberg-Larsen K. Obstetric oxytocin exposure and ADHD and ASD among Danish and Finnish children. Int J Epidemiol 2021;50:446-56. https://doi.org/10.1093/ije/dyaa076
  16. Wiggs KK, Rickert ME, Hernandez-Diaz S, Bateman BT, Almqvist C, Larsson H, et al. A family-based study of the association between labor induction and offspring attention-deficit hyperactivity disorder and low academic achievement. Behav Genet 2017;47:383-93. https://doi.org/10.1007/s10519-017-9852-4
  17. Al-Ayadhi LY. Altered oxytocin and vasopressin levels in autistic children in Central Saudi Arabia. Neurosciences (Riyadh) 2005;10:47-50.
  18. Lefevre A, Sirigu A. The two fold role of oxytocin in social developmental disorders: a cause and a remedy? Neurosci Biobehav Rev 2016;63:168-76. https://doi.org/10.1016/j.neubiorev.2016.01.011
  19. LoParo D, Waldman I. The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: a meta-analysis. Mol Psychiatry 2015; 20:640-6. https://doi.org/10.1038/mp.2014.77