Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Cohort profile: National Investigation of Birth Cohort in Korea study 2008 (NICKs-2008)

  • Kim, Ju Hee (Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • Lee, Jung Eun (Department of Data Science, Sejong University College of Software Convergence) ;
  • Shim, So Min (Department of Data Science, Sejong University College of Software Convergence) ;
  • Ha, Eun Kyo (Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Yon, Dong Keon (Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • Kim, Ok Hyang (Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • Baek, Ji Hyeon (Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • Koh, Hyun Yong (F.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School) ;
  • Chae, Kyu Young (Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine) ;
  • Lee, Seung Won (Department of Data Science, Sejong University College of Software Convergence) ;
  • Han, Man Yong (Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine)
  • Received : 2020.07.23
  • Accepted : 2020.12.24
  • Published : 2021.09.15
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Abstract

Background: An adequate large-scale pediatric cohort based on nationwide administrative data is lacking in Korea. Purpose: This study established the National Investigation of Birth Cohort in Korea study 2008 (NICKs-2008) based on data from a nationwide population-based health screening program and data on healthcare utilization for children. Methods: The NICKs-2008 study consisted of the Korean National Health Insurance System (NHIS) and the National Health Screening Program for Infants and Children (NHSPIC) databases comprising children born in 2008 (n=469,248) and 2009 (n=448,459) in the Republic of Korea. The NHIS database contains data on age, sex, residential area, income, healthcare utilization (International Classification of Diseases10 codes, procedure codes, and drug classification codes), and healthcare providers. The NHSPIC consists of 7 screening rounds. These screening sessions comprised physical examination, developmental screening (rounds 2-7), a general health questionnaire, and age-specific anticipatory guidance. Results: During the 10-year follow-up, 2,718 children (0.3%) died, including more boys than girls (hazard ratio, 1.145; P<0.001). A total of 848,048 children participated in at least 1 of the 7 rounds of the NHSPIC, while 96,046 participated in all 7 screening programs. A total of 823 infants (0.1%) weighed less than 1,000 g, 3,177 (0.4%) weighed 1,000-1,499 g, 37,166 (4.4%) weighed 1,500-2,499 g, 773,081 (91.4%) weighed 2,500-4,000 g, and 32,016 (5.1%) weighed over 4,000 g. There were 23,404 premature babies (5.5%) in 2008 compared to 23,368 (5.6%) in 2009. The developmental screening test indicated appropriate development in 95%-98% of children, follow-up requirements for 1%-4% of children, and recommendations for further evaluation for 1% of children. Conclusion: The NICKs-2008, which integrates data from the NHIS and NHSPIC databases, can be used to analyze disease onset prior to hospitalization based on information such as lifestyle, eating habits, and risk factors.

Keywords

Acknowledgement

This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (NRF2019R1G1A109977912 and NRF 2020R1F1A1076452). Also, this was supported by the Bio & Medical Technology Development Program of the NRF funded by the Korean government (MSIT) (No.2016M3A9E894 1108). The authors thank the National Health Insurance Service.

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