Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Prevalence, comorbidities, diagnosis, and treatment of nonallergic rhinitis: real-world comparison with allergic rhinitis

  • Yum, Hye Yung (Department of Pediatrics, Seoul Medical Center) ;
  • Ha, Eun Kyo (Department of Pediatrics, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Shin, Yoon Ho (Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine) ;
  • Han, Man Yong (Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine)
  • Received : 2020.05.04
  • Accepted : 2020.07.27
  • Published : 2021.08.15
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Abstract

Rhinitis is among the most common respiratory diseases in children. Nonallergic rhinitis, which involves nasal symptoms without evidence of systemic allergic inflammation or infection, is a heterogeneous entity with diverse manifestations and intensities. Nonallergic rhinitis accounts for 16%-89% of the chronic rhinitis cases, affecting 1%-50% (median 10%) of the total pediatric population. The clinical course of nonallergic rhinitis is generally rather mild and less likely to be associated with allergic comorbidities than allergic rhinitis. Here, we aimed to estimate the rate of coexisting comorbidities of nonallergic rhinitis. Nonallergic rhinitis is more prevalent during the first 2 years of life; however, its underestimation for children with atopic tendencies is likely due to low positive rates of specific allergic tests during early childhood. Local allergic rhinitis is a recently noted phenotype with rates similar to those in adults (median, 44%; range, 4%-67%), among patients previously diagnosed with nonallergic rhinitis. Idiopathic rhinitis, a subtype of nonallergic rhinitis, has been poorly studied in children, and its rates are known to be lower than those in adults. The prevalence of nonallergic rhinitis with eosinophilia syndrome is even lower. A correlation between nonallergic rhinitis and pollution has been suggested owing to the recent increase in nonallergic rhinitis rates in highly developing regions such as some Asian countries, but many aspects remain unknown. Conventional treatments include antihistamines, intranasal corticosteroids, and recent treatments include combination of intranasal corticosteroids with azelastin or decongestants. Here we review the prevalence, diagnosis, comorbidities, and treatment recommendations for nonallergic rhinitis versus allergic rhinitis in children.

Keywords

References

  1. Magnusson J, Kull I, Westman M, Hakansson N, Wolk A, Melen E, et al. Fish and polyunsaturated fat intake and development of allergic and nonallergic rhinitis. J Allergy Clin Immunol 2015;136:1247-53.e1-2. https://doi.org/10.1016/j.jaci.2015.05.030
  2. Roberts G, Xatzipsalti M, Borrego LM, Custovic A, Halken S, Hellings PW, et al. Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology. Allergy 2013;68:1102-16. https://doi.org/10.1111/all.12235
  3. Bachert C, van Cauwenberge P, Olbrecht J, van Schoor J. Prevalence, classification and perception of allergic and nonallergic rhinitis in Belgium. Allergy 2006;61:693-8. https://doi.org/10.1111/j.1398-9995.2006.01054.x
  4. Bousquet J, Fokkens W, Burney P, Durham SR, Bachert C, Akdis CA, et al. Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper. Allergy 2008;63:842-53. https://doi.org/10.1111/j.1398-9995.2008.01715.x
  5. Poddighe D, Gelardi M, Licari A, Del Giudice MM, Marseglia GL. Nonallergic rhinitis in children: Epidemiological aspects, pathological features, diagnostic methodology and clinical management. World J Methodol 2016;6:200-13. https://doi.org/10.5662/wjm.v6.i4.200
  6. Lieberman PL, Smith P. Nonallergic rhinitis: treatment. Immunol Allergy Clin North Am 2016;36:305-19. https://doi.org/10.1016/j.iac.2015.12.007
  7. Hellings PW, Klimek L, Cingi C, Agache I, Akdis C, Bachert C, et al. Nonallergic rhinitis: position paper of the European Academy of Allergy and Clinical Immunology. Allergy 2017;72:1657-65. https://doi.org/10.1111/all.13200
  8. Ha EK, Park JH, Lee SJ, Yon DK, Kim JH, Jee HM, et al. Shared and unique individual risk factors and clinical biomarkers in children with allergic rhinitis and obstructive sleep apnea syndrome. Clin Respir J 2020;14:250-9. https://doi.org/10.1111/crj.13124
  9. Chiang WC, Chen YM, Tan HK, Balakrishnan A, Liew WK, Lim HH, et al. Allergic rhinitis and non-allergic rhinitis in children in the tropics: prevalence and risk associations. Pediatr Pulmonol 2012;47:1026-33. https://doi.org/10.1002/ppul.22554
  10. Arshad SH, Holloway JW, Karmaus W, Zhang H, Ewart S, Mansfield L, et al. Cohort profile: the Isle Of Wight Whole Population Birth Cohort (IOWBC). Int J Epidemiol 2018;47:1043-4i. https://doi.org/10.1093/ije/dyy023
  11. Arshad SH, Tariq SM, Matthews S, Hakim E. Sensitization to common allergens and its association with allergic disorders at age 4 years: a whole population birth cohort study. Pediatrics 2001;108:E33. https://doi.org/10.1542/peds.108.2.e33
  12. Arshad SH, Kurukulaaratchy RJ, Fenn M, Waterhouse L, Matthews S. Rhinitis in 10-year-old children and early life risk factors for its development. Acta Paediatr 2002;91:1334-8. https://doi.org/10.1111/j.1651-2227.2002.tb02830.x
  13. Arshad SH, Stevens M, Hide DW. The effect of genetic and environmental factors on the prevalence of allergic disorders at the age of two years. Clin Exp Allergy 1993;23:504-11. https://doi.org/10.1111/j.1365-2222.1993.tb03238.x
  14. Kulig M, Klettke U, Wahn V, Forster J, Bauer CP, Wahn U. Development of seasonal allergic rhinitis during the first 7 years of life. J Allergy Clin Immunol 2000;106:832-9. https://doi.org/10.1067/mai.2000.110098
  15. Westman M, Stjarne P, Asarnoj A, Kull I, van Hage M, Wickman M, et al. Natural course and comorbidities of allergic and nonallergic rhinitis in children. J Allergy Clin Immunol 2012;129:403-8. https://doi.org/10.1016/j.jaci.2011.09.036
  16. Marinho S, Simpson A, Lowe L, Kissen P, Murray C, Custovic A. Rhino-conjunctivitis in 5-year-old children: a population-based birth cohort study. Allergy 2007;62:385-93. https://doi.org/10.1111/j.1398-9995.2006.01294.x
  17. Chawes BL, Bonnelykke K, Kreiner-Moller E, Bisgaard H. Children with allergic and nonallergic rhinitis have a similar risk of asthma. J Allergy Clin Immunol 2010;126:567-73.e1-8. https://doi.org/10.1016/j.jaci.2010.06.026
  18. Ha EK, Baek JH, Lee SY, Park YM, Kim WK, Sheen YH, et al. Association of polysensitization, allergic multimorbidity, and allergy severity: a cross-sectional study of school children. Int Arch Allergy Immunol 2016;171:251-60. https://doi.org/10.1159/000453034
  19. Baek JH, Cho E, Kim MA, Lee SW, Kang YS, Sheen YH, et al. Response to nonallergenic irritants in children with allergic and nonallergic rhinitis. Allergy Asthma Immunol Res 2016;8:346-52. https://doi.org/10.4168/aair.2016.8.4.346
  20. Topal E, Bakirtas A, Yilmaz O, Karagol IH, Arslan U, Arga M, et al. Predictive factors to differentiate between allergic and nonallergic rhinitis in children. Int Forum Allergy Rhinol 2014;4:447-52. https://doi.org/10.1002/alr.21312
  21. Song JY, Ha EK, Sheen YH, Kim MA, Lee SW, Yoon JW, et al. The association of nasal patency with small airway resistance in children with allergic and nonallergic rhinitis. Clin Respir J 2018;12:2264-70. https://doi.org/10.1111/crj.12902
  22. Pinart M, Benet M, Annesi-Maesano I, von Berg A, Berdel D, Carlsen KC, et al. Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study. Lancet Respir Med 2014;2:131-40. https://doi.org/10.1016/S2213-2600(13)70277-7
  23. Herr M, Clarisse B, Nikasinovic L, Foucault C, Le Marec AM, Giordanella JP, et al. Does allergic rhinitis exist in infancy? Findings from the PARIS birth cohort. Allergy 2011;66:214-21. https://doi.org/10.1111/j.1398-9995.2010.02467.x
  24. Hardjojo A, Goh A, Shek LP, Van Bever HP, Teoh OH, Soh JY, et al. Rhinitis in the first 18 months of life: exploring the role of respiratory viruses. Pediatr Allergy Immunol 2015;26:25-33. https://doi.org/10.1111/pai.12330
  25. Ha EK, Na MS, Lee S, Baek H, Lee SJ, Sheen YH, et al. Prevalence and clinical characteristics of local allergic rhinitis in children sensitized to house dust mites. Int Arch Allergy Immunol 2017;174:183-9. https://doi.org/10.1159/000481091
  26. Hamizan AW, Rimmer J, Alvarado R, Sewell WA, Kalish L, Sacks R, et al. Positive allergen reaction in allergic and nonallergic rhinitis: a systematic review. Int Forum Allergy Rhinol 2017;7:868-77. https://doi.org/10.1002/alr.21988
  27. Fuiano N, Fusilli S, Incorvaia C. A role for measurement of nasal IgE antibodies in diagnosis of Alternaria-induced rhinitis in children. Allergol Immunopathol (Madr) 2012;40:71-4. https://doi.org/10.1016/j.aller.2011.03.010
  28. Krajewska-Wojtys A, Jarzab J, Gawlik R, Bozek A. Local allergic rhinitis to pollens is underdiagnosed in young patients. Am J Rhinol Allergy 2016;30:198-201.
  29. Zicari AM, Occasi F, Di Fraia M, Mainiero F, Porzia A, Galandrini R, et al. Local allergic rhinitis in children: novel diagnostic features and potential biomarkers. Am J Rhinol Allergy 2016;30:329-34. https://doi.org/10.2500/ajra.2016.30.4352
  30. Duman H, Bostanci I, Ozmen S, Dogru M. The relevance of nasal provocation testing in children with nonallergic rhinitis. Int Arch Allergy Immunol 2016;170:115-21. https://doi.org/10.1159/000447635
  31. Blanca-Lopez N, Campo P, Salas M, Garcia Rodriguez C, Palomares F, Blanca M, et al. Seasonal local allergic rhinitis in areas with high concentrations of grass pollen. J Investig Allergol Clin Immunol 2016;26:83-91. https://doi.org/10.18176/jiaci.0018
  32. Buntarickpornpan P, Veskitkul J, Pacharn P, Visitsunthorn N, Vichyanond P, Tantilipikorn P, et al. The proportion of local allergic rhinitis to Dermatophagoides pteronyssinus in children. Pediatr Allergy Immunol 2016;27:574-9. https://doi.org/10.1111/pai.12606
  33. Sennekamp J, Joest I, Filipiak-Pittroff B, von Berg A, Berdel D. Local allergic nasal reactions convert to classic systemic allergic reactions: a long-term follow-up. Int Arch Allergy Immunol 2015;166:154-60. https://doi.org/10.1159/000380852
  34. Rondon C, Campo P, Eguiluz-Gracia I, Plaza C, Bogas G, Galindo P, et al. Local allergic rhinitis is an independent rhinitis phenotype: the results of a 10-year follow-up study. Allergy 2018;73:470-8. https://doi.org/10.1111/all.13272
  35. Rondon C, Campo P, Zambonino MA, Blanca-Lopez N, Torres MJ, Melendez L, et al. Follow-up study in local allergic rhinitis shows a consistent entity not evolving to systemic allergic rhinitis. J Allergy Clin Immunol 2014;133:1026-31. https://doi.org/10.1016/j.jaci.2013.10.034
  36. Fokkens WJ. Thoughts on the pathophysiology of nonallergic rhinitis. Curr Allergy Asthma Rep 2002;2:203-9. https://doi.org/10.1007/s11882-002-0020-3
  37. Yon DK, Hwang S, Lee SW, Jee HM, Sheen YH, Kim JH, et al. Indoor exposure and sensitization to formaldehyde among inner-city children with increased risk for asthma and rhinitis. Am J Respir Crit Care Med 2019;200:388-93. https://doi.org/10.1164/rccm.201810-1980le
  38. Numata T, Konno A, Hasegawa S, Hanazawa T, Nagata H, Motosugi H, et al. Pathophysiological features of the nasal mucosa in patients with idiopathic rhinitis compared to allergic rhinitis. Int Arch Allergy Immunol 1999;119:304-13. https://doi.org/10.1159/000024208
  39. Jaradeh SS, Smith TL, Torrico L, Prieto TE, Loehrl TA, Darling RJ, et al. Autonomic nervous system evaluation of patients with vasomotor rhinitis. Laryngoscope 2000;110:1828-31. https://doi.org/10.1097/00005537-200011000-00012
  40. Knipping S, Holzhausen HJ, Riederer A, Schrom T. Allergic and idiopathic rhinitis: an ultrastructural study. Eur Arch Otorhinolaryngol 2009;266:1249-56. https://doi.org/10.1007/s00405-008-0898-z
  41. van Rijswijk JB, Blom HM, Fokkens WJ. Idiopathic rhinitis, the ongoing quest. Allergy 2005;60:1471-81. https://doi.org/10.1111/j.1398-9995.2005.00975.x
  42. Ellis AK, Keith PK. Nonallergic rhinitis with eosinophilia syndrome. Curr Allergy Asthma Rep 2006;6:215-20. https://doi.org/10.1007/s11882-006-0037-0
  43. Schiavino D, Nucera E, Milani A, Della Corte AM, D'Ambrosio C, Pagliari G, et al. Nasal lavage cytometry in the diagnosis of nonallergic rhinitis with eosinophilia syndrome (NARES). Allergy Asthma Proc 1997;18:363-6. https://doi.org/10.2500/108854197778558061
  44. Mullarkey MF, Hill JS, Webb DR. Allergic and nonallergic rhinitis: their characterization with attention to the meaning of nasal eosinophilia. J Allergy Clin Immunol 1980;65:122-6. https://doi.org/10.1016/0091-6749(80)90196-7
  45. Rupp GH, Friedman RA. Eosinophilic nonallergic rhinitis in children. Pediatrics 1982;70:437-9. https://doi.org/10.1542/peds.70.3.437
  46. Crobach M, Hermans J, Kaptein A, Ridderikhoff J, Mulder J. Nasal smear eosinophilia for the diagnosis of allergic rhinitis and eosinophilic nonallergic rhinitis. Scand J Prim Health Care 1996;14:116-21. https://doi.org/10.3109/02813439608997081
  47. Bachert C. Persistent rhinitis - allergic or nonallergic? Allergy 2004;59 Suppl 76:11-5; discussion 5. https://doi.org/10.1111/j.0108-1675.2004.00389.x
  48. Ellegard EK, Karlsson NG, Ellegard LH. Rhinitis in the menstrual cycle, pregnancy, and some endocrine disorders. Clin Allergy Immunol 2007;19:305-21.
  49. Ellegard E, Karlsson G. Nasal congestion during the menstrual cycle. Clin Otolaryngol Allied Sci 1994;19:400-3. https://doi.org/10.1111/j.1365-2273.1994.tb01256.x
  50. Philpott CM, El-Alami M, Murty GE. The effect of the steroid sex hormones on the nasal airway during the normal menstrual cycle. Clin Otolaryngol Allied Sci 2004;29:138-42. https://doi.org/10.1111/j.1365-2273.2004.00801.x
  51. Kaliner MA. Classification of nonallergic rhinitis syndromes with a focus on vasomotor rhinitis, proposed to be known henceforth as nonallergic rhinopathy. World Allergy Organ J 2009;2:98-101. https://doi.org/10.1097/WOX.0b013e3181a9d55b
  52. Navarrete-Palacios E, Hudson R, Reyes-Guerrero G, Guevara-Guzman R. Correlation between cytological characteristics of the nasal epithelium and the menstrual cycle. Arch Otolaryngol Head Neck Surg 2003;129:460-3. https://doi.org/10.1001/archotol.129.4.460
  53. Raphael G, Raphael MH, Kaliner M. Gustatory rhinitis: a syndrome of food-induced rhinorrhea. J Allergy Clin Immunol 1989;83:110-5. https://doi.org/10.1016/0091-6749(89)90484-3
  54. Georgalas C, Jovancevic L. Gustatory rhinitis. Curr Opin Otolaryngol Head Neck Surg 2012;20:9-14. https://doi.org/10.1097/MOO.0b013e32834dfb52
  55. Philip G, Baroody FM, Proud D, Naclerio RM, Togias AG. The human nasal response to capsaicin. J Allergy Clin Immunol 1994;94(6 Pt 1):1035-45. https://doi.org/10.1016/0091-6749(94)90122-8
  56. Leung TF, Ko FW, Wong GW. Roles of pollution in the prevalence and exacerbations of allergic diseases in Asia. J Allergy Clin Immunol 2012;129:42-7. https://doi.org/10.1016/j.jaci.2011.11.031
  57. Deng Q, Lu C, Yu Y, Li Y, Sundell J, Norback D. Early life exposure to traffic-related air pollution and allergic rhinitis in preschool children. Respir Med 2016;121:67-73. https://doi.org/10.1016/j.rmed.2016.10.016
  58. Nikasinovic L, Just J, Sahraoui F, Seta N, Grimfeld A, Momas I. Nasal inflammation and personal exposure to fine particles PM2.5 in asthmatic children. J Allergy Clin Immunol 2006;117:1382-8. https://doi.org/10.1016/j.jaci.2006.03.023
  59. Lee YL, Shaw CK, Su HJ, Lai JS, Ko YC, Huang SL, et al. Climate, traffic-related air pollutants and allergic rhinitis prevalence in middle-school children in Taiwan. Eur Respir J 2003;21:964-70. https://doi.org/10.1183/09031936.03.00094602
  60. Hwang BF, Jaakkola JJ, Lee YL, Lin YC, Guo YL. Relation between air pollution and allergic rhinitis in Taiwanese schoolchildren. Respir Res 2006;7:23. https://doi.org/10.1186/1465-9921-7-23
  61. Chiang TY, Yuan TH, Shie RH, Chen CF, Chan CC. Increased incidence of allergic rhinitis, bronchitis and asthma, in children living near a petrochemical complex with SO2 pollution. Environ Int 2016;96:1-7. https://doi.org/10.1016/j.envint.2016.08.009
  62. Liu W, Huang C, Hu Y, Fu Q, Zou Z, Sun C, et al. Associations of gestational and early life exposures to ambient air pollution with childhood respiratory diseases in Shanghai, China: A retrospective cohort study. Environ Int 2016;92-93:284-93. https://doi.org/10.1016/j.envint.2016.04.019
  63. Seo S, Kim D, Min S, Paul C, Yoo Y, Choung JT. GIS-based association between PM10 and allergic diseases in Seoul: implications for health and environmental policy. Allergy Asthma Immunol Res 2016;8:32-40. https://doi.org/10.4168/aair.2016.8.1.32
  64. Chung HY, Hsieh CJ, Tseng CC, Yiin LM. Association between the first occurrence of allergic rhinitis in preschool children and air pollution in Taiwan. Int J Environ Res Public Health 2016;13:268. https://doi.org/10.3390/ijerph13030268
  65. Parker JD, Akinbami LJ, Woodruff TJ. Air pollution and childhood respiratory allergies in the United States. Environ Health Perspect 2009;117:140-7. https://doi.org/10.1289/ehp.11497
  66. Zhang F, Wang W, Lv J, Krafft T, Xu J. Time-series studies on air pollution and daily outpatient visits for allergic rhinitis in Beijing, China. Sci Total Environ 2011;409:2486-92. https://doi.org/10.1016/j.scitotenv.2011.04.007
  67. Jung DY, Leem JH, Kim HC, Kim JH, Hwang SS, Lee JY, et al. Effect of traffic-related air pollution on allergic disease: results of the children's health and environmental research. Allergy Asthma Immunol Res 2015;7:359-66. https://doi.org/10.4168/aair.2015.7.4.359
  68. Zuraimi MS, Tham KW, Chew FT, Ooi PL, Koh D. Home air-conditioning, traffic exposure, and asthma and allergic symptoms among preschool children. Pediatr Allergy Immunol 2011;22(1 Pt 2):e112-8. https://doi.org/10.1111/j.1399-3038.2010.00992.x
  69. Villeneuve PJ, Doiron MS, Stieb D, Dales R, Burnett RT, Dugandzic R. Is outdoor air pollution associated with physician visits for allergic rhinitis among the elderly in Toronto, Canada? Allergy 2006;61:750-8. https://doi.org/10.1111/j.1398-9995.2006.01070.x
  70. Teng B, Zhang X, Yi C, Zhang Y, Ye S, Wang Y, et al. The association between ambient air pollution and allergic rhinitis: further epidemiological evidence from Changchun, Northeastern China. Int J Environ Res Public Health 2017;14:226. https://doi.org/10.3390/ijerph14030226
  71. Feng S, Gao D, Liao F, Zhou F, Wang X. The health effects of ambient PM2.5 and potential mechanisms. Ecotoxicol Environ Saf 2016;128:67-74. https://doi.org/10.1016/j.ecoenv.2016.01.030
  72. Jean R, Rufin P, Pfister A, Landais P, Waernessyckle S, de Blic J, et al. Diagnostic value of nasal provocation challenge with allergens in children. Allergy 1998;53:990-4. https://doi.org/10.1111/j.1398-9995.1998.tb03802.x
  73. Auge J, Vent J, Agache I, Airaksinen L, Campo Mozo P, Chaker A, et al. EAACI Position paper on the standardization of nasal allergen challenges. Allergy 2018;73:1597-608. https://doi.org/10.1111/all.13416
  74. Jang TY, Kim YH. Nasal provocation test is useful for discriminating allergic, nonallergic, and local allergic rhinitis. Am J Rhinol Allergy 2015;29:e100-4. https://doi.org/10.2500/ajra.2015.29.4214
  75. de Blay F, Doyen V, Lutz C, Godet J, Barnig C, Qi S, et al. A new, faster, and safe nasal provocation test method for diagnosing mite allergic rhinitis. Ann Allergy Asthma Immunol 2015;115:385-90.e1. https://doi.org/10.1016/j.anai.2015.07.014
  76. Baraniuk JN, Kim D. Nasonasal reflexes, the nasal cycle, and sneeze. Curr Allergy Asthma Rep 2007;7:105-11. https://doi.org/10.1007/s11882-007-0007-1
  77. Wight RG, Jones AS, Beckingham E, Andersson B, Ek L. A double blind comparison of intranasal budesonide 400 micrograms and 800 micrograms in perennial rhinitis. Clin Otolaryngol Allied Sci 1992;17:354-8. https://doi.org/10.1111/j.1365-2273.1992.tb01012.x
  78. Webb DR, Meltzer EO, Finn AF Jr, Rickard KA, Pepsin PJ, Westlund R, et al. Intranasal fluticasone propionate is effective for perennial nonallergic rhinitis with or without eosinophilia. Ann Allergy Asthma Immunol 2002;88:385-90. https://doi.org/10.1016/S1081-1206(10)62369-1
  79. Small P, Black M, Frenkiel S. Effects of treatment with beclomethasone dipropionate in subpopulations of perennial rhinitis patients. J Allergy Clin Immunol 1982;70:178-82. https://doi.org/10.1016/0091-6749(82)90039-2
  80. Blom HM, Godthelp T, Fokkens WJ, KleinJan A, Mulder PG, Rijntjes E. The effect of nasal steroid aqueous spray on nasal complaint scores and cellular infiltrates in the nasal mucosa of patients with nonallergic, noninfectious perennial rhinitis. J Allergy Clin Immunol 1997;100(6 Pt 1):739-47. https://doi.org/10.1016/S0091-6749(97)70267-7
  81. Derendorf H, Munzel U, Petzold U, Maus J, Mascher H, Hermann R, et al. Bioavailability and disposition of azelastine and fluticasone propionate when delivered by MP29-02, a novel aqueous nasal spray. Br J Clin Pharmacol 2012;74:125-33. https://doi.org/10.1111/j.1365-2125.2012.04222.x
  82. Berger WE, Shah S, Lieberman P, Hadley J, Price D, Munzel U, et al. Long-term, randomized safety study of MP29-02 (a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate in an advanced delivery system) in subjects with chronic rhinitis. J Allergy Clin Immunol Pract 2014;2:179-85. https://doi.org/10.1016/j.jaip.2013.09.019
  83. Kortekaas Krohn I, Callebaut I, Alpizar YA, Steelant B, Van Gerven L, Skov PS, et al. MP29-02 reduces nasal hyperreactivity and nasal mediators in patients with house dust mite-allergic rhinitis. Allergy 2018;73:1084-93. https://doi.org/10.1111/all.13349
  84. Fokkens W, Hellings P, Segboer C. Capsaicin for Rhinitis. Curr Allergy Asthma Rep 2016;16:60. https://doi.org/10.1007/s11882-016-0638-1
  85. Carr W, Bernstein J, Lieberman P, Meltzer E, Bachert C, Price D, et al. A novel intranasal therapy of azelastine with fluticasone for the treatment of allergic rhinitis. J Allergy Clin Immunol 2012;129:1282-9.e10. https://doi.org/10.1016/j.jaci.2012.01.077
  86. Berger W, Bousquet J, Fox AT, Just J, Muraro A, Nieto A, et al. MP-AzeFlu is more effective than fluticasone propionate for the treatment of allergic rhinitis in children. Allergy 2016;71:1219-22. https://doi.org/10.1111/all.12903
  87. Price D, Shah S, Bhatia S, Bachert C, Berger W, Bousquet J, et al. A new therapy (MP29-02) is effective for the long-term treatment of chronic rhinitis. J Investig Allergol Clin Immunol 2013;23:495-503.
  88. Brown KR, Bernstein JA. Clinically relevant outcome measures of novel pharmacotherapy for nonallergic rhinitis. Curr Opin Allergy Clin Immunol 2015;15:204-12. https://doi.org/10.1097/ACI.0000000000000166
  89. Van Gerven L, Alpizar YA, Steelant B, Callebaut I, Kortekaas Krohn I, Wouters M, et al. Enhanced chemosensory sensitivity in patients with idiopathic rhinitis and its reversal by nasal capsaicin treatment. J Allergy Clin Immunol 2017;140:437-46.e2. https://doi.org/10.1016/j.jaci.2017.03.014
  90. Bernstein JA, Davis BP, Picard JK, Cooper JP, Zheng S, Levin LS. A randomized, double-blind, parallel trial comparing capsaicin nasal spray with placebo in subjects with a significant component of nonallergic rhinitis. Ann Allergy Asthma Immunol 2011;107:171-8. https://doi.org/10.1016/j.anai.2011.05.016
  91. Liu W, Zhou L, Zeng Q, Luo R. Combination of mometasone furoate and oxymetazoline for the treatment of adenoid hypertrophy concomitant with allergic rhinitis: a randomized controlled trial. Sci Rep 2017;7:40425. https://doi.org/10.1038/srep40425
  92. Lockey RF. Rhinitis medicamentosa and the stuffy nose. J Allergy Clin Immunol 2006;118:1017-8. https://doi.org/10.1016/j.jaci.2006.06.018
  93. Akpinar ME, Yigit O, Akakin D, Sarioz O, Ozkan N, Yildiz SD, et al. Topical glucocorticoid reduces the topical decongestant-induced histologic changes in an animal model nasal mucosa. Laryngoscope 2012;122:741-6. https://doi.org/10.1002/lary.23207
  94. Hallen H, Enerdal J, Graf P. Fluticasone propionate nasal spray is more effective and has a faster onset of action than placebo in treatment of rhinitis medicamentosa. Clin Exp Allergy 1997;27:552-8. https://doi.org/10.1111/j.1365-2222.1997.tb00744.x
  95. Ferguson BJ, Paramaesvaran S, Rubinstein E. A study of the effect of nasal steroid sprays in perennial allergic rhinitis patients with rhinitis medicamentosa. Otolaryngol Head Neck Surg 2001;125:253-60. https://doi.org/10.1067/mhn.2001.117717
  96. Vaidyanathan S, Williamson P, Clearie K, Khan F, Lipworth B. Fluticasone reverses oxymetazoline-induced tachyphylaxis of response and rebound congestion. Am J Respir Crit Care Med 2010;182:19-24. https://doi.org/10.1164/rccm.200911-1701OC
  97. Kirtsreesakul V, Khanuengkitkong T, Ruttanaphol S. Does oxymetazoline increase the efficacy of nasal steroids in treating nasal polyposis? Am J Rhinol Allergy 2016;30:195-200. https://doi.org/10.2500/ajra.2016.30.4294
  98. Sears MR, Burrows B, Flannery EM, Herbison GP, Holdaway MD. Atopy in childhood. I. Gender and allergen related risks for development of hay fever and asthma. Clin Exp Allergy 1993;23:941-8. https://doi.org/10.1111/j.1365-2222.1993.tb00279.x
  99. Porro E, Calamita P, Rana I, Montini L, Criscione S. Atopy and environmental factors in upper respiratory infections: an epidemiological survey on 2304 school children. Int J Pediatr Otorhinolaryngol 1992;24:111-20. https://doi.org/10.1016/0165-5876(92)90137-E
  100. Braun-Fahrlander C, Wuthrich B, Gassner M, Grize L, Sennhauser FH, Varonier HS, et al. Validation of a rhinitis symptom questionnaire (ISAAC core questions) in a population of Swiss school children visiting the school health services. SCARPOL-team. Swiss Study on Childhood Allergy and Respiratory Symptom with respect to Air Pollution and Climate. International Study of Asthma and Allergies in Childhood. Pediatr Allergy Immunol 1997;8:75-82. https://doi.org/10.1111/j.1399-3038.1997.tb00147.x
  101. Wright AL, Holberg CJ, Martinez FD, Halonen M, Morgan W, Taussig LM. Epidemiology of physician-diagnosed allergic rhinitis in childhood. Pediatrics 1994;94(6 Pt 1):895-901. https://doi.org/10.1542/peds.94.6.895
  102. Keles N, Ilicali C, Deger K. The effects of different levels of air pollution on atopy and symptoms of allergic rhinitis. Am J Rhinol 1999;13:185-90. https://doi.org/10.2500/105065899781389731
  103. Soto-Quiros ME, Silverman EK, Hanson LA, Weiss ST, Celedon JC. Maternal history, sensitization to allergens, and current wheezing, rhinitis, and eczema among children in Costa Rica. Pediatr Pulmonol 2002;33:237-43. https://doi.org/10.1002/ppul.10070
  104. Kurukulaaratchy RJ, Karmaus W, Raza A, Matthews S, Roberts G, Arshad SH. The influence of gender and atopy on the natural history of rhinitis in the first 18 years of life. Clin Exp Allergy 2011;41:851-9. https://doi.org/10.1111/j.1365-2222.2011.03765.x
  105. Kuyucu S, Saraclar Y, Tuncer A, Geyik PO, Adalioglu G, Akpinarli A, et al. Epidemiologic characteristics of rhinitis in Turkish children: the International Study of Asthma and Allergies in Childhood (ISAAC) phase 2. Pediatr Allergy Immunol 2006;17:269-77. https://doi.org/10.1111/j.1399-3038.2006.00407.x
  106. Carr TF, Stern DA, Halonen M, Wright AL, Martinez FD. Non-atopic rhinitis at age 6 is associated with subsequent development of asthma. Clin Exp Allergy 2019;49:35-43. https://doi.org/10.1111/cea.13276
  107. Papadopoulou A, Hatziagorou E, Matziou VN, Grigoropoulou DD, Panagiotakos DB, Tsanakas JN, et al. Comparison in asthma and allergy prevalence in the two major cities in Greece: the ISAAC phase II survey. Allergol Immunopathol (Madr) 2011;39:347-55. https://doi.org/10.1016/j.aller.2010.10.003
  108. Ulrik CS, von Linstow ML, Backer V. Prevalence and predictors of rhinitis in Danish children and adolescents. Allergy 2000;55:1019-24. https://doi.org/10.1034/j.1398-9995.2000.00630.x
  109. Belgrave DC, Granell R, Simpson A, Guiver J, Bishop C, Buchan I, et al. Developmental profiles of eczema, wheeze, and rhinitis: two population-based birth cohort studies. PLoS Med 2014;11:e1001748. https://doi.org/10.1371/journal.pmed.1001748
  110. Bahceciler NN, Ozdemir C, Kucukosmanoglu E, Arikan C, Over U, Karavelioglu S, et al. Association between previous enterobiasis and current wheezing: evaluation of 1018 children. Allergy Asthma Proc 2007;28:174-82. https://doi.org/10.2500/aap.2007.27.2904
  111. Kurukulaaratchy RJ, Matthews S, Arshad SH. Defining childhood atopic phenotypes to investigate the association of atopic sensitization with allergic disease. Allergy 2005;60:1280-6. https://doi.org/10.1111/j.1398-9995.2005.00890.x
  112. Kim SH, Kim YK, Lee MH, Hong SC, Bae JM, Min KU, et al. Relationship between sensitization to citrus red mite (Panonychus citri) and the prevalence of atopic diseases in adolescents living near citrus orchards. Clin Exp Allergy 2002;32:1054-8. https://doi.org/10.1046/j.1365-2222.2002.01431.x
  113. Bertelsen RJ, Carlsen KC, Carlsen KH. Rhinitis in children: co-morbidities and phenotypes. Pediatr Allergy Immunol 2010;21(4 Pt 1):612-22. https://doi.org/10.1111/j.1399-3038.2010.01066.x
  114. Sobki SH, Zakzouk SM. Point prevalence of allergic rhinitis among Saudi children. Rhinology 2004;42:137-40.
  115. Kong WJ, Chen JJ, Zheng ZY, Shi QM, Zhou Y. Prevalence of allergic rhinitis in 3-6-year-old children in Wuhan of China. Clin Exp Allergy 2009;39:869-74. https://doi.org/10.1111/j.1365-2222.2009.03206.x
  116. Han YY, Forno E, Gogna M, Celedon JC. Obesity and rhinitis in a nationwide study of children and adults in the United States. J Allergy Clin Immunol 2016;137:1460-5. https://doi.org/10.1016/j.jaci.2015.12.1307
  117. Zhang YM, Zhang J, Liu SL, Zhang X, Yang SN, Gao J, et al. Prevalence and associated risk factors of allergic rhinitis in preschool children in Beijing. Laryngoscope 2013;123:28-35. https://doi.org/10.1002/lary.23573
  118. Lee SH, Choi JH, Suh JD, Chung S, Hong SC, Kim JK, et al. Natural Course of allergic and nonallergic rhinitis after 2 years in Korean children. Clin Exp Otorhinolaryngol 2016;9:233-7. https://doi.org/10.21053/ceo.2015.01130
  119. Lee KS, Yum HY, Sheen YH, Park YM, Lee YJ, Choi BS, et al. Comorbidities and phenotypes of rhinitis in Korean children and adolescents: a cross-sectional, multicenter study. Allergy Asthma Immunol Res 2017;9:70-8. https://doi.org/10.4168/aair.2017.9.1.70
  120. Ahn JY, Kim JE, Choi BS. Symptomatic differences between allergic and nonallergic rhinitis in children. Allergy Asthma Respir Dis 2015;3:341-5. https://doi.org/10.4168/aard.2015.3.5.341
  121. Kim DK, Rhee CS, Han DH, Won TB, Kim DY, Kim JW. Treatment of allergic rhinitis is associated with improved attention performance in children: the Allergic Rhinitis Cohort Study for Kids (ARCO-Kids). PLoS One 2014;9:e109145. https://doi.org/10.1371/journal.pone.0109145
  122. Won NH, Park SH, Ahn SH, Kim CB, Kwon JH, Seo WH, et al. Clinical characteristics of allergic rhinitis and nonallergic rhinitis in Korean children. Allergy Asthma Respir Dis 2020;8:20-9. https://doi.org/10.4168/aard.2020.8.1.20
  123. Molgaard E, Thomsen SF, Lund T, Pedersen L, Nolte H, Backer V. Differences between allergic and nonallergic rhinitis in a large sample of adolescents and adults. Allergy 2007;62:1033-7. https://doi.org/10.1111/j.1398-9995.2007.01355.x
  124. Kim SW, Han DH, Lee SJ, Lee CH, Rhee CS. Bronchial hyperresponsiveness in pediatric rhinitis patients: the difference between allergic and nonallergic rhinitis. Am J Rhinol Allergy 2013;27:e63-8. https://doi.org/10.2500/ajra.2013.27.3877
  125. Gelardi M, Iannuzzi L, Tafuri S, Passalacqua G, Quaranta N. Allergic and non-allergic rhinitis: relationship with nasal polyposis, asthma and family history. Acta Otorhinolaryngol Ital 2014;34:36-41.

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