대한한방부인과학회지 (The Journal of Korean Obstetrics and Gynecology)

  • 제34권4호
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  • Pages.30-45
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  • 2021
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  • 1229-4292(pISSN)
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  • 2508-3619(eISSN)
대한한방부인과학회 (The Society of Korean Medicine Obstetrics and Gynecology)
권호 표지
DOI QR코드

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임신 관련 3종 한약 처방 물 추출물과 목단피 에탄올 추출물이 자궁내막과 태반세포에 미치는 영향

The Effects of Pregnancy-Related Water Extract of 3 Types Herbal Medicines and Ethanol Extract of Moutan Radicis Cortex on the Endometrial and Placental Cells

  • 박서예 (산부인과, 건양대학교 의과대학) ;
  • 노의정 (산부인과, 건양대학교 의과대학) ;
  • 서창섭 (한의과학연구부, 한국한의학연구원) ;
  • 이성기 (산부인과, 건양대학교 의과대학) ;
  • 신현규 (한의과학연구부, 한국한의학연구원)
  • Park, Seo-Ye (Dep. of Obstetrics and Gynecology, College of Medicine, Konyang University) ;
  • Noh, Eui-Jeong (Dep. of Obstetrics and Gynecology, College of Medicine, Konyang University) ;
  • Seo, Chang-Seob (KM Science Research Division, Korea Institute of Oriental Medicine) ;
  • Lee, Sung-Ki (Dep. of Obstetrics and Gynecology, College of Medicine, Konyang University) ;
  • Shin, Hyeun-Kyoo (KM Science Research Division, Korea Institute of Oriental Medicine)
  • 투고 : 2021.10.15
  • 심사 : 2021.11.26
  • 발행 : 2021.11.26
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초록

Objectives: This study was performed to investigate the effects of pregnancy-related four herbal medicines (Samul-tang, Onkyung-tang, Chokyungjongok-tang and Moutan Radicis Cortex) on the endometrial and placental cells. Methods: In this study, we examined viability and decidualization of telomerase immortalized human endometrial stromal cell lines (T-HESCs) and viability and invasion ability of human first trimester trophoblast cell lines Sw.71 by four herbal medicines (Samul-tang, Onkyung-tang, Chokyungjongok-tang and Moutan Radicis Cortex) Results: In the study, we showed that Samul-tang, Onkyung-tang, Chokyungjongok-tang increased decidualization marker prolactin (PRL) and insulin-like growth factor-binding protein 1 (IGFBP1) in T-HESCs. Moutan Radicis Cortex decreased the mRNA level of PRL and IGFBP1, and the protein level of PRL and IGFBP1 had no significant effect. Moreover, four herbal medicines reduced invasion ability of Sw.71 cells. Conclusions: These results suggest that Samul-tang, Onkyung-tang, and Chokyungjongok-tang have beneficial effects on successful embryo implantation and pregnancy maintenance by increasing decidualization markers such as PRL and IGFBP1. Moutan Radicis Cortex reduces the mRNA levels of PRL and IGFBP1, which may adversely affect pregnancy. Further investigations are needed to elucidate the significance of the decreased invasive ability of Sw.71 cells induced by four herbal medications.

키워드

과제정보

본 연구는 한국한의학연구원 기관고유 사업인 한방의료기관 한약처방 안전성·유효성 구축 사업(KSN2021310), 한국연구재단 기초연구사업(NRF-2017R1A6A1A03015713), 및 보건복지부(HI17C1238)으로 부터 지원 받았음.

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