Acknowledgement
This work was supported by United States National Institutes of Health grant R01 GM118122. Thanks are extended to K. Trisler for assistance in preparation of the manuscript and to Y. Tateishi for the paradigm shown in Fig. 4. This review is dedicated to an old friend, Dr. Anthony Y. H. Lu, who shared my enthusiasm of P450 research for many years and introduced me to many applications in the pharmaceutical industry, and to the memory of our mutual mentor, Professor Minor J. Coon (1921-2018), who taught us both well.
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