Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Clinical Characteristics of Formal Thought Disorder in Schizophrenia

조현병에서 형식적 사고장애의 임상적 특성

  • Yang, Chaeyoung (Department of Psychiatry, Hanyang University College of Medicine) ;
  • Kim, Han-sung (Department of Psychiatry, Yong-In Mental Hospital) ;
  • Kim, Eunkyung (Department of Psychiatry, Hanyang University Guri Hospital) ;
  • Kim, Il Bin (Department of Psychiatry, Hanyang University Guri Hospital) ;
  • Park, Seon-Cheol (Department of Psychiatry, Hanyang University College of Medicine) ;
  • Choi, Joonho (Department of Psychiatry, Hanyang University College of Medicine)
  • 양채영 (한양대학교 의과대학 정신건강의학교실) ;
  • 김한성 (용인정신병원 정신건강의학과) ;
  • 김은경 (한양대학교 구리병원 정신건강의학과) ;
  • 김일빈 (한양대학교 구리병원 정신건강의학과) ;
  • 박선철 (한양대학교 의과대학 정신건강의학교실) ;
  • 최준호 (한양대학교 의과대학 정신건강의학교실)
  • Received : 2021.08.19
  • Accepted : 2021.09.28
  • Published : 2021.10.31
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Abstract

Objectives Our study aimed to present the distinctive correlates of formal thought disorder in patients with schizophrenia, using the Clinical Language Disorder Rating Scale (CLANG). Methods We compared clinical characteristics between schizophrenia patients with (n = 84) and without (n = 82) formal thought disorder. Psychometric scales including the CLANG, the Brief Psychiatric Rating Scale (BPRS), the Young Mania Rating Scale (YMRS), the Calgery Depression Scale for Schizophrenia (CDSS) and the Word Fluency Test (WFT) were used. Results After adjusting the effects of age, sex and total scores on the BPRS, YMRS and WFT, the subjects with disorganized speech presented significantly higher score on the abnormal syntax (p = 0.009), lack of semantic association (p = 0.005), discourse failure (p < 0.0001), pragmatics disorder (p = 0.001), dysarthria (p < 0.0001), and paraphasic error (p = 0.005) items than those without formal thought disorder. With defining the mentioned item scores as covariates, binary logistic regression model predicted that discourse failure (adjusted odds ratio [aOR] = 5.88, p < 0.0001) and pragmatics disorder (aOR = 2.17, p = 0.04) were distinctive correlates of formal thought disorder in patients with schizophrenia. Conclusions This study conducted Clinician Rated Dimensions of Psychosis Symptom Severity (CRDPSS) and CLANG scales on 166 hospitalized schizophrenia patients to explore the sub-items of the CLANG scale independently related to formal thought disorders in schizophrenia patients. Discourse failure and pragmatics disorder might be used as the distinctive indexes for formal thought disorder in patients with schizophrenia.

Keywords

Acknowledgement

The authors thank Dr. Jiyeong Kim (Lab. of Biostatistical Consulting and Research, Medical Research Collaborating Center, Industry-University Cooperation Foundation, Hanyang University) for the statistical advice. This work was supported by the research fund of Hanyang University (HY-202100000001303).

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