Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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A Profile of Glucose-6-Phosphate Dehydrogenase Variants and Deficiency of Multicultural Families in Korea

  • Bahk, Young Yil (Department of Biotechnology, College of Biomedical and Health Science, Konkuk University) ;
  • Ahn, Seong Kyu (Infectious Diseases Investigation Division, Jeonnam Institute of Public Health and Environment) ;
  • Lee, Jinyoung (Department of Parasitology and Tropical Medicine & Global Resource Bank of Parasitic Protozoa Pathogens, Inha University School of Medicine) ;
  • Im, Jae Hyoung (Division of Infection Diseases, Department of Internal Medicine, Inha University School of Medicine) ;
  • Yeom, Joon-Sup (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Park, Sookkyung (Bureau of Infectious Disease Policy, Korea Disease Control and Prevention Agency) ;
  • Kwon, Jeongran (Bureau of Infectious Disease Policy, Korea Disease Control and Prevention Agency) ;
  • Kan, Hyesu (Bureau of Infectious Disease Policy, Korea Disease Control and Prevention Agency) ;
  • Kim, Miyoung (Bureau of Infectious Disease Policy, Korea Disease Control and Prevention Agency) ;
  • Jang, Woori (Department of Laboratory Medicine, Inha University School of Medicine) ;
  • Kim, Tong-Soo (Department of Parasitology and Tropical Medicine & Global Resource Bank of Parasitic Protozoa Pathogens, Inha University School of Medicine)
  • Received : 2021.07.20
  • Accepted : 2021.08.11
  • Published : 2021.10.31
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Abstract

Vivax malaria incidence in Korea is now decreased and showing a low plateau. Nowadays, vivax malaria in Korea is expected to be successfully eliminated with anti-malaria chemotherapy, primaquine, and vector control. The glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with potential hemolytic anemia after primaquine administration. This inborn disorder has a pivotal polymorphism with genetic variants and is the most prevalent X-chromosome-linked disorder. The prevalence of G6PD deficiency was previously reported negligible in Korea. As the population of multicultural families pertaining marriage immigrants and their adolescents increases, it is necessary to check G6PD deficiency for them prior to primaquine treatment for vivax malaria. The prevalence of G6PD variants and G6PD deficiency in multicultural families was performed in 7 counties and 2 cities of Jeollanam-do (Province), Gyeonggi-do, and Gangwon-do. A total of 733 blood samples of multicultural family participants were subjected to test the phenotypic and genetic G6PD deficiency status using G6PD enzyme activity quantitation kit and PCR-based G6PD genotyping kit. The G6PD phenotypic deficiency was observed in 7.8% of male adolescent participants and 3.2% of materfamilias population. Based on the PCR-based genotyping, we observed total 35 participants carrying the mutated alleles. It is proposed that primaquine prescription should seriously be considered prior to malaria treatment.

Keywords

Acknowledgement

This study was supported by the Korea Disease Control and Prevention Agency (4851-304-320) and the National Research Foundation of Korea (NRF) grants funded by the Korean Government (NRF-2019K1A3A9A01000005 and NRF-2017M3A9B8069530).

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