대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
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기능성소화불량 환자에서 나타나는 정신적 증상의 한약 치료 : 체계적 문헌고찰과 메타분석

Herbal Medicine for Functional Dyspepsia with Psychological Symptoms: A Systematic Review and Meta-Analysis

  • 조윤재 (경희대학교 대학원 임상한의학과) ;
  • 이하늘 (경희대학교 대학원 임상한의학과) ;
  • 정해인 (경희대학교 대학원 임상한의학과) ;
  • 이현진 (경희대학교 대학원 임상한의학과) ;
  • 금창열 (경희대학교 대학원 임상한의학과) ;
  • 한아람 (경희대학교 대학원 임상한의학과) ;
  • 하나연 (경희대학교한방병원 위장소화내과) ;
  • 김진성 (경희대학교 대학원 임상한의학과)
  • Cho, Yun-jae (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Lee, Hanul (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Jeong, Hae In (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Lee, Hyun-Jin (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Keum, Chang-Yul (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Han, Aram (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Ha, Na-Yeon (Dept. of Digestive Diseases, Kyung Hee University Korean Medicine Hospital) ;
  • Kim, Jinsung (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University)
  • 투고 : 2021.07.21
  • 심사 : 2021.09.30
  • 발행 : 2021.09.30
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초록

Purpose: Functional dyspepsia (FD) is a chronic syndrome accompanied by repetitive digestive symptoms that appear in the upper gastrointestinal tract and are not caused by specific diseases. Psychological symptoms like anxiety, depression, insomnia, and somatization are frequently observed in FD. The purpose of this study was to review the effect of herbal medicine on the psychological symptoms that accompany FD. Methods: Database search (PubMed, EMBASE, KISS, Kmbase, KoreanMed, NDSL, OASIS, CNKI) was performed on February 24, 2021; a total of 1825 studies were searched. After the screening, 22 studies were included. Results: The studies were assessed by Cochrane RoB 2 and sorted into a table according to psychological symptoms. Meta-analysis was performed to estimate the effect of herbal medicine. Twenty of the twenty-two studies reported that herbal medicine was significantly more effective than the control group. Only three of the studies did not have a high risk of bias. Conclusion: Herbal medicine was significantly effective with or without Western medicine and had fewer adverse effects. Severe adverse effect was not reported. Psychological symptoms in FD affect onset and duration of FD, and some FD patients want to be treated for their anxiety before other symptoms. Reliable information about treatment for the psychological symptoms of FD is lacking. We reviewed the effect of herbal medicine treatment in this study, the results of which could be selected for primary or secondary treatment for FD.

키워드

참고문헌

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