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Anticancer Activity of Indeno[1,2-b]-Pyridinol Derivative as a New DNA Minor Groove Binding Catalytic Inhibitor of Topoisomerase IIα

  • Jeon, Kyung-Hwa (College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University) ;
  • Shrestha, Aarajana (College of Pharmacy, Yeungnam University) ;
  • Jang, Hae Jin (College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University) ;
  • Kim, Jeong-Ahn (College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University) ;
  • Sheen, Naeun (College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University) ;
  • Seo, Minjung (College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University) ;
  • Lee, Eung-Seok (College of Pharmacy, Yeungnam University) ;
  • Kwon, Youngjoo (College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University)
  • 투고 : 2020.12.18
  • 심사 : 2021.04.07
  • 발행 : 2021.09.01

초록

Topoisomerase IIα has been a representative anti-cancer target for decades thanks to its functional necessity in highly proliferative cancer cells. As type of topoisomerase IIα targeting drugs, topoisomerase II poisons are frequently in clinical usage. However, topoisomerase II poisons result in crucial consequences resulted from mechanistically induced DNA toxicity. For this reason, it is needed to develop catalytic inhibitors of topoisomerase IIα through the alternative mechanism of enzymatic regulation. As a catalytic inhibitor of topoisomerase IIα, AK-I-191 was previously reported for its enzyme inhibitory activity. In this study, we clarified the mechanism of AK-I-191 and conducted various types of spectroscopic and biological evaluations for deeper understanding of its mechanism of action. Conclusively, AK-I-191 represented potent topoisomerase IIα inhibitory activity through binding to minor groove of DNA double helix and showed synergistic effects with tamoxifen in antiproliferative activity.

키워드

과제정보

This work was supported by grants from National Research Foundation of Korea (NRF) grants funded by the Korean government (MSIT) (2018R1A5A2025286, 2017R1A2B2003944, and 2019R1I1A1A01050921).

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피인용 문헌

  1. AK-I-190, a New Catalytic Inhibitor of Topoisomerase II with Anti-Proliferative and Pro-Apoptotic Activity on Androgen-Negative Prostate Cancer Cells vol.22, pp.20, 2021, https://doi.org/10.3390/ijms222011246