Journal of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회지)

Korean Society of Radiopharmaceuticals and Molecular Probes (대한방사성의약품학회)
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Calix-Arene based phase transfer catalysts fornucleophilic fluorination

  • Minji Nam (Department of Chemistry and Chemical Engineering, Inha University) ;
  • Dong Wook Kim (Department of Chemistry and Chemical Engineering, Inha University)
  • Received : 2021.06.07
  • Accepted : 2021.06.28
  • Published : 2021.12.30
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Abstract

With increasing interest in fluorinated compounds, nucleophilic fluorination reaction has been generally used for synthesizing fluorine-containing chemicals. However, alkali metal fluorides (MFs) generally have low solubility and reactivity in organic solvent. To overcome these problems, various phase transfer catalysts (PTCs) have been investigated. Calix-arene is known as to capture the metal cation(M+), and therefore in this review, we would like to introduce several kinds of calix-arene based PTCs, such as bis-tert-alcohol-functionalized crown-6-calix[4]arene (BACCA), oligo-ethylene glycol linked bis-triethyleneglycol crown-5-calix[4]arene (BTC5A), and ionic liquid functionalized calix-arene based catalyst, as well as ion-pair receptor crown-6-calix[4]arene-capped calix[4]pyrrole.

Keywords

Acknowledgement

This work was supported by the Basic Science Research Program (grant code:NRF20201AC1009017), administered through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and Future Planning, KOREA.

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