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Organometallic fluorine-18 bonds in 18F-radiochemistry

  • Joong-Hyun Chun (Department of Nuclear Medicine, Yonsei University College of Medicine) ;
  • Minju Lee (Department of Nuclear Medicine, Yonsei University College of Medicine) ;
  • Sungwon Jun (Department of Nuclear Medicine, Yonsei University College of Medicine) ;
  • Jeongmin Son (Department of Nuclear Medicine, Severance Hospital, Yonsei University Health System)
  • Received : 2021.06.07
  • Accepted : 2021.06.28
  • Published : 2021.06.30

Abstract

Fluorine-18 is by far the most widely exploited radionuclide in PET (positron emission tomography) radiochemistry. The physical half-life of fluorine-18 allows for chemical manipulation within a restricted timeframe, and cyclotron-produced fluoride ion has been widely applied in aliphatic and aromatic nucleophilic radiofluorinations to produce a variety of established radiotracers. Radiotracers have become more structurally complicated to address diverse targets in physiobiological systems. There is therefore an unmet need to complement traditional C-18F bond-forming radiofluorination with new and efficient radiolabeling techniques to tackle the myriad of possible chemical environments. This review discusses recent advances in organometallic fluorine-18 bond creation in 18F-radiochemistry. Although not widely employed, new radiolabeling strategies for constructing boron-18F, silicon-18F, aluminum-18F, and other metal-18F bonds are described in view of their potential use in the development of novel radiopharmaceuticals.

Keywords

Acknowledgement

이 논문은 한국연구재단의 재원으로 마련한 개인연구사업(NRF-2019R1F1A1058774)의 지원을 받아 수행되었으며, 이권에 대한 문제를 일으킬 수 있는 상업적인 관련성은 없음을 밝힙니다.

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