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The Role of Mobility of Cognition and Emotion in Elderly : A Conceptual Review

노인의 운동성과 인지 및 정서의 관계에 대한 개념적 고찰

  • Kim, Kayoung (Department of Geriatric Psychiatry, National Center for Mental Health)
  • Received : 2021.03.29
  • Accepted : 2021.04.08
  • Published : 2021.04.30

Abstract

Considering that the aged population increases and the mobility problem is pointed out as a factor that indisposes the quality of life, cognition, and mood, it is important to understand and evaluate the elderly's mobility. Factors that deteriorate mobility in the elderly include physical senility, various health changes including chronic diseases, polypharmacy as well as anticholinergics. Common mobility problems in old age are reduced gait speed, increased gait variability in walking length, careless walking, and frequent falls. Several studies have reported that decreased mobility and deterioration of gait can predict cognitive decline and emotional problems. Aerobic exercise, resistance exercise, and balance exercise are suggested as therapeutic interventions for mobility problems. Active correction for factors that reduce mobility in the elderly and prescribing physical activity can conserve the elderly's quality of life and help improve cognition and mood. There is a need for related research in the future.

Keywords

References

  1. Population Projections for Korea (2017-2067) [Internet]. Daejeon: Statistics Korea. 2019.
  2. Li L, Loo BPY. Mobility impairment, social engagement, and life satisfaction among the older population in China: a structural equation modeling analysis. Qual Life Res 2017;26:1273-1282. https://doi.org/10.1007/s11136-016-1444-x
  3. Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB. Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med 1995;332:556-562. https://doi.org/10.1056/NEJM199503023320902
  4. Lee S, Choi H. Impact of older adults' mobility and social participation on life satisfaction in South Korea. Asian Soc Work Pol Rev 2020; 14:4-10. https://doi.org/10.1111/aswp.12187
  5. Demnitz N, Zsoldos E, Mahmood A, Mackay CE, Kivimaki M, Singh-Manoux A, et al. Associations between Mobility, Cognition, and Brain Structure in Healthy Older Adults. Front Aging Neurosci [serial online]. 2017 [cited 2021 Mar 9];9. Available from URL: https://doi.org/10.3389/fnagi.2017.00155.
  6. Byun S, Han JW, Kim TH, Kim K, Kim TH, Park JY, et al. Gait variability can predict the risk of cognitive decline in cognitively normal older people. Dement Geriatr Cogn Disord 2018;45:251-261. https://doi.org/10.1159/000489927
  7. Hardy SE, Kang Y, Studenski SA, Degenholtz HB. Ability to walk 1/4 mile predicts subsequent disability, mortality, and health care costs. J Gen Intern Med 2011;26:130-135. https://doi.org/10.1007/s11606-010-1543-2
  8. Son KY, Shin DW, Lee JE, Kim SH, Yun JM, Cho B. Association of timed up and go test outcomes with future incidence of cardiovascular disease and mortality in adults aged 66years: Korean national representative longitudinal study over 5.7years. BMC Geriatr 2020; 20:111. https://doi.org/10.1186/s12877-020-01509-8
  9. Nutt JG, Marsden CD, Thompson PD. Human walking and higherlevel gait disorders, particularly in the elderly. Neurology 1993;43: 268-279. https://doi.org/10.1212/WNL.43.2.268
  10. Latt MD, Menz HB, Fung VS, Lord SR. Walking speed, cadence and step length are selected to optimize the stability of head and pelvis accelerations. Exp Brain Res 2008;184:201-209. https://doi.org/10.1007/s00221-007-1094-x
  11. Panel on Prevention of Falls in Older Persons, American Geriatrics Society and British Geriatrics Society. Summary of the updated American Geriatrics Society/British Geriatrics Society clinical practice guideline for prevention of falls in older persons. J Am Geriatr Soc 2011;59:148-157. https://doi.org/10.1111/j.1532-5415.2010.03234.x
  12. Muir SW, Gopaul K, Montero Odasso MM. The role of cognitive impairment in fall risk among older adults: a systematic review and meta-analysis. Age Ageing 2012;41:299-308. https://doi.org/10.1093/ageing/afs012
  13. Coppin AK, Shumway-Cook A, Saczynski JS, Patel KV, Ble A, Ferrucci L, et al. Association of executive function and performance of dual-task physical tests among older adults: analyses from the InChianti study. Age Ageing 2006;35:619-624. https://doi.org/10.1093/ageing/afl107
  14. Podsiadlo D, Richardson S. The timed "Up & Go": a test of basic functional mobility for frail elderly persons. J Am Geriatr Soc 1991; 39:142-148. https://doi.org/10.1111/j.1532-5415.1991.tb01616.x
  15. Berg K, Wood-Dauphine S, Williams JI, Gayton D. Measuring balance in the elderly: preliminary development of an instrument. Physiother Can 1989;41:304-311. https://doi.org/10.3138/ptc.41.6.304
  16. Okumiya K, Matsubayashi K, Nakamura T, Fujisawa M, Osaki Y, Doi Y, et al. The timed "up & go" test is a useful predictor of falls in community-dwelling older people. J Am Geriatr Soc 1998;46:928-929. https://doi.org/10.1111/j.1532-5415.1998.tb02737.x
  17. Beauchet O, Fantino B, Allali G, Muir SW, Montero-Odasso M, Annweiler C. Timed Up and Go test and risk of falls in older adults: a systematic review. J Nutr Health Aging 2011;15:933-938. https://doi.org/10.1007/s12603-011-0062-0
  18. Lima CA, Ricci NA, Nogueira EC, Perracini MR. The Berg Balance Scale as a clinical screening tool to predict fall risk in older adults: a systematic review. Physiotherapy 2018;104:383-394. https://doi.org/10.1016/j.physio.2018.02.002
  19. Guralnik JM, Ferrucci L, Pieper CF, Leveille SG, Markides KS, Ostir GV, et al. Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. J Gerontol A Biol Sci Med Sci 2000;55:M221-M231. https://doi.org/10.1093/gerona/55.4.M221
  20. Shumway-Cook A, Guralnik JM, Phillips CL, Coppin AK, Ciol MA, Bandinelli S, et al. Age-associated declines in complex walking task performance: the walking InCHIANTI toolkit. J Am Geriatr Soc 2007;55:58-65. https://doi.org/10.1111/j.1532-5415.2006.00962.x
  21. Forssberg H, Grillner S, Halbertsma J. The locomotion of the low spinal cat I. Coordination within a hindlimb. Acta Physiol Scand 1980; 108:269-281. https://doi.org/10.1111/j.1748-1716.1980.tb06533.x
  22. Lord SR, Clark RD, Webster IW. Postural stability and associated physiological factors in a population of aged persons. J Gerontol 1991;46:M69-M76. https://doi.org/10.1093/geronj/46.3.M69
  23. Segev-Jacubovski O, Herman T, Yogev-Seligmann G, Mirelman A, Giladi N, Hausdorff JM. The interplay between gait, falls and cognition: can cognitive therapy reduce fall risk? Expert Rev Neurother 2011;11:1057-1075. https://doi.org/10.1586/ern.11.69
  24. Winter DA, Patla AE, Frank JS, Walt SE. Biomechanical walking pattern changes in the fit and healthy elderly. Phys Ther 1990;70: 340-347. https://doi.org/10.1093/ptj/70.6.340
  25. Elble RJ, Thomas SS, Higgins C, Colliver J. Stride-dependent changes in gait of older people. J Neurol 1991;238:1-5. https://doi.org/10.1007/BF00319700
  26. Cruz-Jimenez M. Normal changes in gait and mobility problems in the elderly. Phys Med Rehabil Clin N Am 2017;28:713-725. https://doi.org/10.1016/j.pmr.2017.06.005
  27. Ko SU, Ling SM, Winters J, Ferrucci L. Age-related mechanical work expenditure during normal walking: the Baltimore Longitudinal Study of Aging. J Biomech 2009;42:1834-1839. https://doi.org/10.1016/j.jbiomech.2009.05.037
  28. Kafri M, Sasson E, Assaf Y, Balash Y, Aiznstein O, Hausdorff JM, et al. High-level gait disorder: associations with specific white matter changes observed on advanced diffusion imaging. J Neuroimaging 2013;23:39-46. https://doi.org/10.1111/j.1552-6569.2012.00734.x
  29. Mansfield A, Mochizuki G, Inness EL, McIlroy WE. Clinical correlates of between-limb synchronization of standing balance control and falls during inpatient stroke rehabilitation. Neurorehabil Neural Repair 2012;26:627-635. https://doi.org/10.1177/1545968311429688
  30. Brandler TC, Wang C, Oh-Park M, Holtzer R, Verghese J. depressive symptoms and gait dysfunction in the elderly. Am J Geriatr Psychiatry 2012;20:425-432. https://doi.org/10.1097/JGP.0b013e31821181c6
  31. Grober E, Dickson D, Sliwinski MJ, Buschke H, Katz M, Crystal H, et al. Memory and mental status correlates of modified Braak staging. Neurobiol Aging 1999;20:573-579. https://doi.org/10.1016/S0197-4580(99)00063-9
  32. Green RC, Cupples LA, Kurz A, Auerbach S, Go R, Sadovnick D, et al. Depression as a risk factor for Alzheimer disease: the MIRAGE study. Arch Neurol 2003;60:753-759. https://doi.org/10.1001/archneur.60.5.753
  33. Ownby RL, Crocco E, Acevedo A, John V, Loewenstein D. Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis. Arch Gen Psychiatry 2006;63:530-538. https://doi.org/10.1001/archpsyc.63.5.530
  34. Wang YC, Lin FG, Yu CP, Tzeng YM, Liang CK, Chang YW, et al. Depression as a predictor of falls amongst institutionalized elders. Aging Ment Health 2012;16:763-770. https://doi.org/10.1080/13607863.2012.678479
  35. Yogev-Seligmann G, Hausdorff JM, Giladi N. The role of executive function and attention in gait. Mov Disord 2008;23:329-342. https://doi.org/10.1002/mds.21720
  36. van Iersel MB, Verbeek ALM, Bloem BR, Munneke M, Esselink RA, Rikkert MGMO. Frail elderly patients with dementia go too fast. J Neurol Neurosurg Psychiatry 2006;77:874-876. https://doi.org/10.1136/jnnp.2005.084418
  37. Yogev G, Giladi N, Peretz C, Springer S, Simon ES, Hausdorff JM. Dual tasking, gait rhythmicity, and Parkinson's disease: which aspects of gait are attention demanding? Eur J Neurosci 2005;22:1248-1256. https://doi.org/10.1111/j.1460-9568.2005.04298.x
  38. Springer S, Giladi N, Peretz C, Yogev G, Simon ES, Hausdorff JM. Dual-tasking effects on gait variability: the role of aging, falls, and executive function. Mov Disord 2006;21:950-957. https://doi.org/10.1002/mds.20848
  39. Marcum ZA, Perera S, Thorpe JM, Switzer GE, Gray SL, Castle NG, et al. Anticholinergic use and recurrent falls in community-dwelling older adults: findings from the health ABC study. Ann Pharmacother 2015;49:1214-1221. https://doi.org/10.1177/1060028015596998
  40. Grande G, Tramacere I, Vetrano DL, Clerici F, Pomati S, Mariani C, et al. Role of anticholinergic burden in primary care patients with first cognitive complaints. Eur J Neurol 2017;24:950-955. https://doi.org/10.1111/ene.13313
  41. Campbell NL, Lane KA, Gao S, Boustani MA, Unverzagt F. Anticholinergics influence transition from normal cognition to mild cognitive impairment in older adults in primary care. Pharmacotherapy 2018;38:511-519. https://doi.org/10.1002/phar.2106
  42. Lopez-Alvarez J, Sevilla-Llewellyn-Jones J, Aguera-Ortiz L. Anticholinergic drugs in geriatric psychopharmacology. Front Neurosci 2019;13:1309. https://doi.org/10.3389/fnins.2019.01309
  43. Haroutunian V, Greig N, Pei XF, Utsuki T, Gluck R, Acevedo LD, et al. Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions. Brain Res Mol Brain Res 1997;46:161-168. https://doi.org/10.1016/S0169-328X(96)00297-5
  44. Jenraumjit R, Chinwong S, Chinwong D, Kanjanarach T, Kshetradat T, Wongpakaran T, et al. Anticholinergics and benzodiazepines on cognitive impairment among elderly with Alzheimer's disease: a 1 year follow-up study. BMC Res Notes 2020;13:4. https://doi.org/10.1186/s13104-019-4874-z
  45. Attoh-Mensah E, Loggia G, Schumann-Bard P, Morello R, Descatoire P, Marcelli C, et al. Adverse effects of anticholinergic drugs on cognition and mobility: cutoff for impairment in a cross-sectional study in young-old and old-old adults. Drugs Aging 2020;37:301-310. https://doi.org/10.1007/s40266-019-00743-z
  46. Jun K, Ah YM, Hwang S, Chung JE, Lee JY. Prevalence of anticholinergic burden and risk factors amongst the older population: analysis of insurance claims data of Korean patients. Int J Clin Pharm 2020;42:453-461. https://doi.org/10.1007/s11096-020-01010-7
  47. Deshpande N, Metter EJ, Bandinelli S, Guralnik J, Ferrucci L. Gait speed under varied challenges and cognitive decline in older persons: a prospective study. Age ageing 2009;38:509-514. https://doi.org/10.1093/ageing/afp093
  48. Montero-Odasso M, Speechley M, Muir-Hunter SW, Sarquis-Adamson Y, Sposato LA, Hachinski V, et al. Motor and cognitive trajectories before dementia: results from gait and brain study. J Am Geriatr Soc 2018;66:1676-1683. https://doi.org/10.1111/jgs.15341
  49. Beauchet O, Allali G, Annweiler C, Bridenbaugh S, Assal F, Kressig RW, et al. Gait variability among healthy adults: low and high strideto-stride variability are both a reflection of gait stability. Gerontology 2009;55:702-706. https://doi.org/10.1159/000235905
  50. Wennberg AMV, Savica R, Hagen CE, Roberts RO, Knopman DS, Hollman JH, et al. Cerebral amyloid deposition is associated with gait parameters in the Mayo Clinic Study of Aging. J Am Geriatr Soc 2017;65:792-799. https://doi.org/10.1111/jgs.14670
  51. Tian Q, Chastan N, Bair WN, Resnick SM, Ferrucci L, Studenski SA. The brain map of gait variability in aging, cognitive impairment and dementia-a systematic review. Neurosci Biobehav Rev 2017;74:149-162. https://doi.org/10.1016/j.neubiorev.2017.01.020
  52. Verghese J, Wang C, Lipton RB, Holtzer R. Motoric cognitive risk syndrome and the risk of dementia. J Gerontol A Biol Sci Med Sci 2013;68:412-418. https://doi.org/10.1093/gerona/gls191
  53. Shim H, Kim M, Won CW. Motoric cognitive risk syndrome is associated with processing speed and executive function, but not delayed free recall memory: the Korean Frailty and Aging Cohort Study (KFACS). Arch Gerontol Geriatr 2020;87:103990. https://doi.org/10.1016/j.archger.2019.103990
  54. Veronese N, Stubbs B, Trevisan C, Bolzetta F, De Rui M, Solmi M, et al. Poor physical performance predicts future onset of depression in elderly people: Progetto Veneto Anziani Longitudinal Study. Phys Ther 2017;97:659-668. https://doi.org/10.1093/ptj/pzx017
  55. Sherrington C, Michaleff ZA, Fairhall N, Paul SS, Tiedemann A, Whitney J, et al. Exercise to prevent falls in older adults: an updated systematic review and meta-analysis. Br J Sports Med 2017;51:1750-1758. https://doi.org/10.1136/bjsports-2016-096547
  56. Panza GA, Taylor BA, MacDonald HV, Johnson BT, Zaleski AL, Livingston J, et al. Can exercise improve cognitive symptoms of Alzheimer's disease? J Am Geriatr Soc 2018;66:487-495. https://doi.org/10.1111/jgs.15241
  57. Schuch FB, Vancampfort D, Rosenbaum S, Richards J, Ward PB, Veronese N, et al. Exercise for depression in older adults: a meta-analysis of randomized controlled trials adjusting for publication bias. Braz J Psychiatry 2016;38:247-254. https://doi.org/10.1590/1516-4446-2016-1915
  58. Borde R, Hortobagyi T, Granacher U. Dose-response relationships of resistance training in healthy old adults: a systematic review and meta-analysis. Sports Med 2015;45:1693-1720. https://doi.org/10.1007/s40279-015-0385-9
  59. Szuhany KL, Bugatti M, Otto MW. A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor. J Psychiatr Res 2015;60:56-64. https://doi.org/10.1016/j.jpsychires.2014.10.003
  60. Schuch FB, Deslandes AC, Stubbs B, Gosmann NP, da Silva CTB, Fleck MP. Neurobiological effects of exercise on major depressive disorder: a systematic review. Neurosci Biobehav Rev 2016;61:1-11. https://doi.org/10.1016/j.neubiorev.2015.11.012