참고문헌
- Liu J, Lian X, Liu F, Yan X, Cheng C, Cheng L, et al. Identification of novel key targets and candidate drugs in oral squamous cell carcinoma. Curr Bioinform 2020;15:328-337. https://doi.org/10.2174/1574893614666191127101836
- Maruccia M, Onesti MG, Parisi P, Cigna E, Troccola A, Scuderi N. Lip cancer: a 10-year retrospective epidemiological study. Anticancer Res 2012;32:1543-1546.
- Kerawala C, Roques T, Jeannon JP, Bisase B. Oral cavity and lip cancer: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol 2016;130(S2):S83-S89.
- Montero PH, Patel SG. Cancer of the oral cavity. Surg Oncol Clin N Am 2015;24:491-508. https://doi.org/10.1016/j.soc.2015.03.006
- Shield KD, Ferlay J, Jemal A, Sankaranarayanan R, Chaturvedi AK, Bray F, et al. The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. CA Cancer J Clin 2017;67: 51-64. https://doi.org/10.3322/caac.21384
- Gupta B, Bray F, Kumar N, Johnson NW. Associations between oral hygiene habits, diet, tobacco and alcohol and risk of oral cancer: a case-control study from India. Cancer Epidemiol 2017;51: 7-14. https://doi.org/10.1016/j.canep.2017.09.003
- Gupta B, Kumar N, Johnson NW. Relationship of lifetime exposure to tobacco, alcohol and second hand tobacco smoke with upper aero-digestive tract cancers in India: a case-control study with a life-course perspective. Asian Pac J Cancer Prev 2017; 18:347-356.
- Salehiniya H, Raei M. Oral cavity and lip cancer in the world: an epidemiological review. Biomed Res Ther 2020;7:3898-3905. https://doi.org/10.15419/bmrat.v7i8.619
- Merchant A, Husain SS, Hosain M, Fikree FF, Pitiphat W, Siddiqui AR, et al. Paan without tobacco: an independent risk factor for oral cancer. Int J Cancer 2000;86:128-131. https://doi.org/10.1002/(SICI)1097-0215(20000401)86:1<128::AID-IJC20>3.0.CO;2-M
- Pinero J, Queralt-Rosinach N, Bravo A, Deu-Pons J, Bauer-Mehren A, Baron M, et al. DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes. Database (Oxford) 2015;2015:bav028. https://doi.org/10.1093/database/bav028
- Shen LI, Liu L, Yang Z, Jiang N. Identification of genes and signaling pathways associated with squamous cell carcinoma by bioinformatics analysis. Oncol Lett 2016;11:1382-1390. https://doi.org/10.3892/ol.2015.4051
- Chin CH, Chen SH, Wu HH, Ho CW, Ko MT, Lin CY. cytoHubba: identifying hub objects and sub-networks from complex interactome. BMC Syst Biol 2014;8 Suppl 4:S11. https://doi.org/10.1186/1752-0509-8-S4-S11
- Wang J, Duncan D, Shi Z, Zhang B. WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013. Nucleic Acids Res 2013;41:W77-W83. https://doi.org/10.1093/nar/gkt439
- Pathan M, Keerthikumar S, Ang CS, Gangoda L, Quek CY, Williamson NA, et al. FunRich: an open access standalone functional enrichment and interaction network analysis tool. Proteomics 2015;15:2597-2601. https://doi.org/10.1002/pmic.201400515
- von Mering C, Huynen M, Jaeggi D, Schmidt S, Bork P, Snel B. STRING: a database of predicted functional associations between proteins. Nucleic Acids Res 2003;31:258-261. https://doi.org/10.1093/nar/gkg034
- Baschieri F, Confalonieri S, Bertalot G, Di Fiore PP, Dietmaier W, Leist M, et al. Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis. Nat Commun 2014;5:4839. https://doi.org/10.1038/ncomms5839
- Prior SL, Griffiths AP, Baxter JM, Baxter PW, Hodder SC, Silvester KC, et al. Mitochondrial DNA mutations in oral squamous cell carcinoma. Carcinogenesis 2006;27:945-950. https://doi.org/10.1093/carcin/bgi326
- Park EM, Park YM, Gwak YS. Oxidative damage in tissues of rats exposed to cigarette smoke. Free Radic Biol Med 1998;25:79-86. https://doi.org/10.1016/S0891-5849(98)00041-0
- Richter C, Park JW, Ames BN. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci U S A 1988;85:6465-6467. https://doi.org/10.1073/pnas.85.17.6465
- van Niel G, D'Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol 2018;19: 213-228. https://doi.org/10.1038/nrm.2017.125
- Kujan O, van Schaijik B, Farah CS. Immune checkpoint inhibitors in oral cavity squamous cell carcinoma and oral potentially malignant disorders: a systematic review. Cancers (Basel) 2020;12:1937. https://doi.org/10.3390/cancers12071937
- Weng LP, Wu CC, Hsu BL, Chi LM, Liang Y, Tseng CP, et al. Secretome-based identification of Mac-2 binding protein as a potential oral cancer marker involved in cell growth and motility. J Proteome Res 2008;7:3765-3775. https://doi.org/10.1021/pr800042n
- Nagler RM, Lischinsky S, Diamond E, Klein I, Reznick AZ. New insights into salivary lactate dehydrogenase of human subjects. J Lab Clin Med 2001;137:363-369. https://doi.org/10.1067/mlc.2001.114710
- Bahar G, Feinmesser R, Shpitzer T, Popovtzer A, Nagler RM. Salivary analysis in oral cancer patients: DNA and protein oxidation, reactive nitrogen species, and antioxidant profile. Cancer 2007; 109:54-59. https://doi.org/10.1002/cncr.22386
- Jourenkova-Mironova N, Mitrunen K, Bouchardy C, Dayer P, Benhamou S, Hirvonen A. High-activity microsomal epoxide hydrolase genotypes and the risk of oral, pharynx, and larynx cancers. Cancer Res 2000;60:534-536.
- Jourenkova-Mironova N, Voho A, Bouchardy C, Wikman H, Dayer P, Benhamou S, et al. Glutathione S-transferase GSTM1, GSTM3, GSTP1 and GSTT1 genotypes and the risk of smoking-related oral and pharyngeal cancers. Int J Cancer 1999;81:44-48. https://doi.org/10.1002/(SICI)1097-0215(19990331)81:1<44::AID-IJC9>3.0.CO;2-A
- Lopez-Lazaro M. The Warburg effect: why and how do cancer cells activate glycolysis in the presence of oxygen? Anticancer Agents Med Chem 2008;8:305-312. https://doi.org/10.2174/187152008783961932
- Todd R, Donoff RB, Wong DT. The molecular biology of oral carcinogenesis: toward a tumor progression model. J Oral Maxillofac Surg 1997;55:613-623. https://doi.org/10.1016/S0278-2391(97)90495-X
- Weiner T, Cance WG. Molecular mechanisms involved in tumorigenesis and their surgical implications. Am J Surg 1994;167:428-434. https://doi.org/10.1016/0002-9610(94)90129-5
- Spangle JM, Roberts TM, Zhao JJ. The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer. Biochim Biophys Acta Rev Cancer 2017;1868:123-131. https://doi.org/10.1016/j.bbcan.2017.03.002
- Patel KR, Vajaria BN, Begum R, Patel JB, Shah FD, Joshi GM, et al. VEGFA isoforms play a vital role in oral cancer progression. Tumour Biol 2015;36:6321-6332. https://doi.org/10.1007/s13277-015-3318-1
- Supic G, Jovic N, Zeljic K, Kozomara R, Magic Z. Association of VEGF-A genetic polymorphisms with cancer risk and survival in advanced-stage oral squamous cell carcinoma patients. Oral Oncol 2012;48:1171-1177. https://doi.org/10.1016/j.oraloncology.2012.05.023
- Nibali L, Fedele S, D'Aiuto F, Donos N. Interleukin-6 in oral diseases: a review. Oral Dis 2012;18:236-243. https://doi.org/10.1111/j.1601-0825.2011.01867.x
- Gasche JA, Hoffmann J, Boland CR, Goel A. Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells. Int J Cancer 2011;129:1053-1063. https://doi.org/10.1002/ijc.25764
- Peng Q, Deng Z, Pan H, Gu L, Liu O, Tang Z. Mitogen-activated protein kinase signaling pathway in oral cancer. Oncol Lett 2018;15:1379-1388.
- Goutzanis L, Vairaktaris E, Yapijakis C, Kavantzas N, Nkenke E, Derka S, et al. Diabetes may increase risk for oral cancer through the insulin receptor substrate-1 and focal adhesion kinase pathway. Oral Oncol 2007;43:165-173. https://doi.org/10.1016/j.oraloncology.2006.02.004
- Sahibzada HA, Khurshid Z, Khan RS, Naseem M, Siddique KM, Mali M, et al. Salivary IL-8, IL-6 and TNF-alpha as potential diagnostic biomarkers for oral cancer. Diagnostics (Basel) 2017;7:21. https://doi.org/10.3390/diagnostics7020021
- Peisker A, Raschke GF, Fahmy MD, Guentsch A, Roshanghias K, Hennings J, et al. Salivary MMP-9 in the detection of oral squamous cell carcinoma. Med Oral Patol Oral Cir Bucal 2017;22: e270-e275.
- Ha NH, Park DG, Woo BH, Kim DJ, Choi JI, Park BS, et al. Porphyromonas gingivalis increases the invasiveness of oral cancer cells by upregulating IL-8 and MMPs. Cytokine 2016;86:64-72. https://doi.org/10.1016/j.cyto.2016.07.013
- Xu Q, Zhang Q, Ishida Y, Hajjar S, Tang X, Shi H, et al. EGF induces epithelial-mesenchymal transition and cancer stem-like cell properties in human oral cancer cells via promoting Warburg effect. Oncotarget 2017;8:9557-9571. https://doi.org/10.18632/oncotarget.13771
- Peng X, Li W, Johnson WD, Torres KE, McCormick DL. Overexpression of lipocalins and pro-inflammatory chemokines and altered methylation of PTGS2 and APC2 in oral squamous cell carcinomas induced in rats by 4-nitroquinoline-1-oxide. PLoS One 2015;10:e0116285. https://doi.org/10.1371/journal.pone.0116285
- Yang B, Dong K, Guo P, Guo P, Jie G, Zhang G, et al. Identification of key biomarkers and potential molecular mechanisms in oral squamous cell carcinoma by bioinformatics analysis. J Comput Biol 2020;27:40-54. https://doi.org/10.1089/cmb.2019.0211
- Huang GZ, Wu QQ, Zheng ZN, Shao TR, Lv XZ. Identification of candidate biomarkers and analysis of prognostic values in oral squamous cell carcinoma. Front Oncol 2019;9:1054. https://doi.org/10.3389/fonc.2019.01054
- Wang J, Wang Y, Kong F, Han R, Song W, Chen D, et al. Identification of a six-gene prognostic signature for oral squamous cell carcinoma. J Cell Physiol 2020;235:3056-3068. https://doi.org/10.1002/jcp.29210