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Evaluation of craniofacial morphology in short-statured children: growth hormone deficiency versus idiopathic short stature

  • Kim, Ki Bong (Department of Dentistry, Yeungnam University College of Medicine) ;
  • Kim, Eun-Kyong (Department of Dental Hygiene, College of Science and Technology, Kyungpook National University) ;
  • Jang, Kyung Mi (Department of Pediatrics, Yeungnam University College of Medicine) ;
  • Kim, Min Seon (Department of Dentistry, Yeungnam University Hospital) ;
  • Park, Eun Young (Department of Dentistry, Yeungnam University College of Medicine)
  • Received : 2020.05.07
  • Accepted : 2020.06.11
  • Published : 2021.01.31

Abstract

Background: Short stature is defined as a height below the 3rd percentile or more than two standard deviations below the mean for a given age, sex, and population. There have been inconsistent results regarding craniofacial morphology in short-statured children. This study aimed to analyze the differences between short-statured children with growth hormone deficiency, idiopathic short-statured children, and normal children. Methods: Thirty-one short-statured children with growth hormone deficiency, 32 idiopathic short-statured children, and 32 healthy children were enrolled in this study. The measurements of their craniofacial structures from lateral cephalograms were evaluated. Results: There were statistically significant differences among the three groups seven variables (anterior cranial base length, posterior cranial base length, total cranial base length, upper posterior facial height, posterior total facial height, mandibular ramus length, and overall mandibular length) in the linear measurement and five variables (saddle angle, gonial angle, mandibular plane angle, position of mandible, and maxilla versus mandible) in the angular measurement. Conclusion: Compared to the control group, many linear and angular measurements of the craniofacial structures were significantly different in the two short-statured groups (p <0.05). Treatment plans by orthodontists should include these craniofacial structure characteristics.

Keywords

References

  1. Herpin N. Le pouvoir des grands: de l'influence de la taille des hommes sur leur statut social. Paris: Decouverte; 2006.
  2. You JB. "My son should be 175cm and daughter 165cm or more"… Parents worry about discrimination [Internet]. JungAng Ilbo; 2020 Oct 21 [cited 2020 Jun 10]. https://news.joins. com/article/18905427.
  3. Barstow C, Rerucha C. Evaluation of short and tall stature in children. Am Fam Physician 2015;92:43-50.
  4. Cox LA. The biology of bone maturation and ageing. Acta Paediatr Suppl 1997;423:107-8. https://doi.org/10.1111/j.1651-2227.1997.tb18386.x
  5. Cao F, Huang HK, Pietka E, Gilsanz V. Digital hand atlas and web-based bone age assessment: system design and implementation. Comput Med Imaging Graph 2000;24:297-307. https://doi.org/10.1016/S0895-6111(00)00026-4
  6. Bilgili Y, Hizel S, Kara SA, Sanli C, Erdal HH, Altinok D. Accuracy of skeletal age assessment in children from birth to 6 years of age with the ultrasonographic version of the Greulich-Pyle atlas. J Ultrasound Med 2003;22:683-90. https://doi.org/10.7863/jum.2003.22.7.683
  7. Lindsay R, Feldkamp M, Harris D, Robertson J, Rallison M. Utah Growth Study: growth standards and the prevalence of growth hormone deficiency. J Pediatr 1994;125:29-35. https://doi.org/10.1016/S0022-3476(94)70117-2
  8. Grote FK, Oostdijk W, De Muinck Keizer-Schrama SM, van Dommelen P, van Buuren S, Dekker FW, et al. The diagnostic work up of growth failure in secondary health care; an evaluation of consensus guidelines. BMC Pediatr 2008;8:21. https://doi.org/10.1186/1471-2431-8-21
  9. Lashari SK, Korejo HB, Memon YM. To determine frequency of etiological factors in short statured patients presenting at an endocrine clinic of a tertiary care hospital. Pak J Med Sci 2014; 30:858-61.
  10. Spiegel RN, Sather AH, Hayles AB. Cephalometric study of children with various endocrine diseases. Am J Orthod 1971; 59:362-75. https://doi.org/10.1016/0002-9416(71)90232-6
  11. Konfino R, Pertzelan A, Laron Z. Cephalometric measurements of familial dwarfism and high plasma immunoreactive growth hormone. Am J Orthod 1975;68:196-201. https://doi.org/10.1016/0002-9416(75)90208-0
  12. Cantu G, Buschang PH, Gonzalez JL. Differential growth and maturation in idiopathic growth-hormone-deficient children. Eur J Orthod 1997;19:131-9. https://doi.org/10.1093/ejo/19.2.131
  13. Kjellberg H, Beiring M, Albertsson Wikland K. Craniofacial morphology, dental occlusion, tooth eruption, and dental maturity in boys of short stature with or without growth hormone deficiency. Eur J Oral Sci 2000;108:359-67. https://doi.org/10.1034/j.1600-0722.2000.108005359.x
  14. Partyka M, Dunin-Wilczynska I, Chalas R. Disorders of the stomatognathic system in patients with short stature. PolMerkur Lekarski 2014;36:63-7.
  15. Broadbent BH Sr, Broadbent BH Jr, Golden WH. Bolton standards of dentofacial development growth. St. Louis: CV Mosby; 1975.
  16. Pirinen S, Majurin A, Lenko HL, Koski K. Craniofacial features in patients with deficient and excessive growth hormone. J Craniofac Genet Dev Biol 1994;14:144-52.
  17. Thilander B. Basic mechanisms in craniofacial growth. Acta Odontol Scand 1995;53:144-51. https://doi.org/10.3109/00016359509005964
  18. Nanda RS. The rate of growth of several facial components measured from serial cephalometric roentgenograms. Am J Orthod 1955;41:658-73. https://doi.org/10.1016/0002-9416(55)90112-3
  19. Bjork A, Helm S. Prediction of the age of maximum puberal growth in body height. Angle Orthod 1967;37:134-43.
  20. Baughan B, Demirjian A, Levesque GY, Lapalme-Chaput L. The pattern of facial growth before and during puberty, as shown by French-Canadian girls. Ann Hum Biol 1979;6:59-76. https://doi.org/10.1080/03014467900003371
  21. Chung SH, Kim JW, Park YH, Hwang CJ, Lee HK. The effect of growth hormone treatment on craniofacial growth in short stature children. Korean J Orthod 2010;40:227-38. https://doi.org/10.4041/kjod.2010.40.4.227
  22. Van Erum R, Mulier M, Carels C, de Zegher F. Short stature of prenatal origin: craniofacial growth and dental maturation. Eur J Orthod 1998;20:417-25. https://doi.org/10.1093/ejo/20.4.417
  23. Poole AE, Greene IM, Buschang PH. The effect of growth hormone therapy on longitudinal growth of the oral facial structures in children. Prog Clin Biol Res 1982;101:499-516.
  24. Grimberg A, Kutikov JK, Cucchiara AJ. Sex differences in patients referred for evaluation of poor growth. J Pediatr 2005; 146:212-6. https://doi.org/10.1016/j.jpeds.2004.09.009

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