Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Transcranial magnetic stimulation parameters as neurophysiological biomarkers in Alzheimer's disease

  • Lee, Juyoun (Department of Neurology, Chungnam National University Hospital) ;
  • Lee, Ae Young (Department of Neurology, Chungnam National University Hospital)
  • Received : 2021.02.01
  • Accepted : 2021.03.29
  • Published : 2021.04.30
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Abstract

Transcranial magnetic stimulation (TMS) is a safe and noninvasive tool for investigating the cortical excitability of the human brain and the neurophysiological functions of GABAergic, glutamatergic, and cholinergic neural circuits. Neurophysiological biomarkers based on TMS parameters can provide information on the pathophysiology of dementia, and be used to diagnose Alzheimer's disease and differentiate different types of dementia. This review introduces the basic principles of TMS, TMS devices and stimulating paradigms, several neurophysiological measurements, and the clinical implications of TMS for Alzheimer's disease.

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References

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