Journal of Periodontal and Implant Science

  • 제51권3호
  • /
  • Pages.199-212
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  • 2021
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  • 2093-2278(pISSN)
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  • 2093-2286(eISSN)
대한치주과학회 (Korean Academy of Periodontology)
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Localized probiotic-guided pocket recolonization in the treatment of chronic periodontitis: a randomized controlled clinical trial

  • Kumar, Vikram (Department of Periodontology, Faculty of Dental Sciences, King George's Medical University) ;
  • Singhal, Rameshwari (Department of Periodontology, Faculty of Dental Sciences, King George's Medical University) ;
  • Rastogi, Pavitra (Department of Periodontology, Faculty of Dental Sciences, King George's Medical University) ;
  • Lal, Nand (Department of Periodontology, Faculty of Dental Sciences, King George's Medical University) ;
  • Pandey, Shivani (Department of Periodontology, Faculty of Dental Sciences, King George's Medical University) ;
  • Mahdi, Abbas Ali (Department of Periodontology, Faculty of Dental Sciences, King George's Medical University)
  • 투고 : 2020.05.30
  • 심사 : 2020.12.30
  • 발행 : 2021.06.30
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초록

Purpose: This randomized clinical placebo-controlled trial was conducted to evaluate the effectiveness of Lactobacillus reuteri as a probiotic in guided pocket recolonization (GPR) for the treatment of chronic periodontitis (CP) adjunctive to scaling and root planing (SRP). Methods: Forty-eight CP patients were randomly assigned to 3 treatment groups: group 1 (SRP+placebo), group 2 (SRP+single application of probiotic), and group 3 (SRP+incremental application of probiotic). Clinical parameters were evaluated at baseline and at 8, 12, and 24 weeks, whereas biochemical parameters were measured at baseline and 12 weeks. Results: At 24 weeks, the probing pocket depth and clinical attachment level improved in all 3 groups from baseline with no significant intergroup differences; however, a statistically significant difference was observed in localized plaque and gingival scores between groups 1 and 3 (P<0.05). At 12 weeks, matrix metalloproteinase-8 (MMP-8), nitric oxide (NO), and gingipains-R (Rgps) levels improved in all 3 groups, with statistically significant differences between groups 1 and 3 for MMP-8 and NO (P<0.05), but no difference for Rgps levels. Conclusions: Within its limitations, the results of this study show that incremental 3-time application of L. reuteri as a probiotic led to improvements in clinical and biochemical parameters. This protocol can be a useful adjunct to SRP in the non-surgical management of CP.

키워드

과제정보

This study was partially supported by an intramural research grant for a postgraduate dissertation, King George's Medical University, Lucknow, India (Grant No. 1149/R-cell16 dated December 26, 2016.)

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