Journal of Ginseng Research

  • 제45권3호
  • /
  • Pages.371-379
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  • 2021
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  • 1226-8453(pISSN)
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  • 2093-4947(eISSN)
고려인삼학회 (The Korean Society of Ginseng)
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DOI QR Code

Review of ginsenosides targeting mitochondrial function to treat multiple disorders: Current status and perspectives

  • Huang, Qingxia (Jilin Ginseng Academy, Changchun University of Chinese Medicine) ;
  • Gao, Song (Jilin Xiuzheng Pharmaceutical New Drug Development Co., Ltd) ;
  • Zhao, Daqing (Jilin Ginseng Academy, Changchun University of Chinese Medicine) ;
  • Li, Xiangyan (Jilin Ginseng Academy, Changchun University of Chinese Medicine)
  • 투고 : 2020.04.22
  • 심사 : 2020.12.09
  • 발행 : 2021.05.01
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⟨ 이전 논문 다음 논문 ⟩

초록

Mitochondrial dysfunction contributes to the pathogenesis and prognosis of many common disorders, including neurodegeneration, stroke, myocardial infarction, tumor, and metabolic diseases. Ginsenosides, the major bioactive constituents of Panax ginseng (P. ginseng), have been reported to play beneficial roles in the molecular pathophysiology of these diseases by targeting mitochondrial dysfunction. In this review, we first introduce the types of ginsenosides and basic mitochondrial functions. Then, recent findings are summarized on different ginsenosides targeting mitochondria and their key signaling pathways for the treatment of multiple diseases, including neurological disorders, cancer, heart disease, hyperglycemia, and inflammation are summarized. This review may explain the common targets of ginsenosides against multiple diseases and provide new insights into the underlying mechanisms, facilitating research on the clinical application of P. ginseng.

키워드

과제정보

This work was supported by the National Key Research and Development Program of China (No. 2017YFC1702103, 2019 YFC1709901), Regional Innovation and Development Joint Fund (U19A2013), National Natural Science Foundation of China (81602257), the Science and Technology Development Plan Project of Jilin Province (No. 20190101010JH, 202002053JC)), Jilin Provincial Administration of Traditional Chinese Medicine (2020168) and the Project for Science and Technology Bureau of Changchun (No. 18YJ013).

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