DOI QR코드

DOI QR Code

A Performance Comparison of Histogram Equalization Algorithms for Cervical Cancer Classification Model

평활화 알고리즘에 따른 자궁경부 분류 모델의 성능 비교 연구

  • Kim, Youn Ji (Department of Biomedical Engineering, Gachon University) ;
  • Park, Ye Rang (Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences and Technology (GAIHST), Gachon University) ;
  • Kim, Young Jae (Department of Biomedical Engineering, Gachon University) ;
  • Ju, Woong (Department of Obstetrics & Gynecology, Ewha Womans University Seoul Hospital) ;
  • Nam, Kyehyun (Department of Obstetrics & Gynecology, Soonchunhyang University, Bucheon Hospital) ;
  • Kim, Kwang Gi (Department of Biomedical Engineering, Gachon University)
  • 김윤지 (가천대학교 의용생체공학과) ;
  • 박예랑 (가천대학교 융합의과학과) ;
  • 김영재 (가천대학교 의용생체공학과) ;
  • 주웅 (이화여자대학교 산부인과) ;
  • 남계현 (순천향대학교 부천병원 산부인과) ;
  • 김광기 (가천대학교 의용생체공학과)
  • Received : 2021.03.11
  • Accepted : 2021.06.28
  • Published : 2021.06.30

Abstract

We developed a model to classify the absence of cervical cancer using deep learning from the cervical image to which the histogram equalization algorithm was applied, and to compare the performance of each model. A total of 4259 images were used for this study, of which 1852 images were normal and 2407 were abnormal. And this paper applied Image Sharpening(IS), Histogram Equalization(HE), and Contrast Limited Adaptive Histogram Equalization(CLAHE) to the original image. Peak Signal-to-Noise Ratio(PSNR) and Structural Similarity index for Measuring image quality(SSIM) were used to assess the quality of images objectively. As a result of assessment, IS showed 81.75dB of PSNR and 0.96 of SSIM, showing the best image quality. CLAHE and HE showed the PSNR of 62.67dB and 62.60dB respectively, while SSIM of CLAHE was shown as 0.86, which is closer to 1 than HE of 0.75. Using ResNet-50 model with transfer learning, digital image-processed images are classified into normal and abnormal each. In conclusion, the classification accuracy of each model is as follows. 90.77% for IS, which shows the highest, 90.26% for CLAHE and 87.60% for HE. As this study shows, applying proper digital image processing which is for cervical images to Computer Aided Diagnosis(CAD) can help both screening and diagnosing.

Keywords

Acknowledgement

This research was supported by the MSIT (Ministry of Science and ICT), Korea, under the ITRC (Information Technology Research Center) support program (IITP-2021-2017-0-01630) supervised by the IITP (Institute for Information & communications Technology Promotion), and by the Technology development Program (S2797147) funded by the Ministry of SMEs and Startups (MSS, korea).

References

  1. Korea Central Cancer Registry, National Cancer Center. Annual report of cancer statistics in Korea in 2017. Ministry of Health and Welfare. 2019; 33.
  2. http://opendata.hira.or.kr/op/opc/olap3thDsInfo.do. Accessed on 23 Feb 2021.
  3. https://www.hira.or.kr/bbsDummy.do;INTERSESSIONID=g4BoNr8ikGPGbzbX8V4OWHwPnvCxfaVCw8Ef9JZb9LzudJguEp37!1206362664!375626493?pgmid=HIRAA020041000100&brdScnBltNo=4&brdBltNo=9774. Accessed on 15 Feb 2021.
  4. https://www.cancer.gov/types/cervical/patient/cervical-treatment-pdq. Accessed on 5 Feb 2021.
  5. Coppleson, LW. Barry Brown. Estimation of the screening error rate from the observed detection rates in repeated cervical cytology. American Journal of Obstetrics and Gynecology. 1974;119(7):953-958. https://doi.org/10.1016/0002-9378(74)90013-1
  6. Zarchi MK, Binesh F, Kazemi Z, Teimoori S, Soltani HR, Chiti Z. Value of colposcopy in the early diagnosis of cervical cancer in patients with abnormal pap smears at Shahid Sadoughi Hospital, Yazd. Asian Pacific Journal of Cancer Prevention. 2011;12(12):3439-3441.
  7. https://www.ksog.org/public/index.php?sub=4. Accessed on 3 Feb 2021.
  8. Alyafeai Z, Ghouti L. A fully-automated deep learning pipeline for cervical cancer classification. Expert Systems with Applications. 2020;141.
  9. Wu M, Yan C, Liu H, Liu Q, Yin Y. Automatic classification of cervical cancer from cytological images by using convolutional neural network. Bioscience Reports. 2018;38(6):1-9.
  10. Kudva V, Prasad K, Guruvare S. Transfer Learning for Classification of Uterine Cervix Images for Cervical Cancer Screening. Lecture Notes in Electrical Engineering. 2020; 614:299-312. https://doi.org/10.1007/978-981-15-0626-0_25
  11. Lange H. Automatic detection of multi-level acetowhite regions in RGB color images of the uterine cervix. Medical Imaging 2005: Image Processing. 2005;5747:1004. https://doi.org/10.1117/12.596064
  12. Lee Y, Kim HJ, Kim GB, Kim N. Deep Learning-based Feature Extraction for Medical Image Analysis. 2014;1-12.
  13. Jeelani H, Martin J, Vasquez F, Salerno M, Weller DS. Image quality affects deep learning reconstruction of MRI. International Symposium on Biomedical Imaging. 2018;357-360.
  14. Guo P, Singh S, Xue Z, Long R, Antani S. Deep learning for assessing image focus for automated cervical cancer screening. 2019 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2019. 2019;2019-2022.
  15. Ulku EE, Camurcu AY. Computer aided brain tumor detection with histogram equalization and morphological image processing techniques. ICECCO 2013. 2013;48-51.
  16. Ullah Z, Farooq MU, Lee SH, An D. A hybrid image enhancement based brain MRI images classification technique. Medical Hypotheses. 2020;143:109922. https://doi.org/10.1016/j.mehy.2020.109922
  17. Ziaei A, Yeganeh H, Faez K, Sargolzaei S. A novel approach for contrast enhancement in biomedical images based on histogram equalization. BMEI 2008. 2008;1:855-858.
  18. Suralkar SR, Rajput, S. Enhancement of Images Using Contrast Image Enhancement Techniques. International Journal of Recent Advances in Engineering & Technology. 2020;8(3):16-20. https://doi.org/10.46564/ijraet.2020.v08i03.004
  19. Singh RP, Dixit M. Histogram Equalization: A Strong Technique for Image Enhancement. International Journal of Signal Processing, Image Processing and Pattern Recognition. 2015;8(8):345-352. https://doi.org/10.14257/ijsip.2015.8.8.35
  20. Gonzalez RC, Woods RE. Digital Image Processing 3rd Edition (Issue 3). New Jersey, Pearson Education, Inc. 2008;394-460.
  21. Russo F. Piecewise Linear Model-Based Image Enhancement. EURASIP J. Adv. Signal Process. 2004;983173.
  22. https://docs.opencv.org/3.4/d4/d1b/tutorial_histogram_equalization.html. Accessed on 17 Feb 2021.
  23. Yun JW. Deep Residual Learning for Image Recognition arXiv:1512.03385v1. Enzyme and Microbial Technology. 1996;19(2):107-117. https://doi.org/10.1016/0141-0229(95)00188-3
  24. Kurt B, Nabiyev VV, Turhan K. Medical images enhancement by using anisotropic filter and CLAHE. INISTA 2012 - International Symposium on INnovations in Intelligent SysTems and Applications. 2012;1-4.
  25. Kim M. Feature Extraction on a Periocular Region and Person Authentication Using a ResNet Model. Journal of Korea Multimedia Society. 2019;22(1):1347-1355
  26. Weiss K, Khoshgoftaar TM, Wang DD. A survey of transfer learning. In Journal of Big Data. Springer International Publishing. 2016;3(1).
  27. Hore A, Ziou D. Image quality metrics: PSNR vs. SSIM. International Conference on Pattern Recognition. 2010;2366-2369.
  28. Kang K, Lee J. PSNR Appraisal of MRI image. 2009;3(4): 13-20.
  29. Wang Z, Bovik AC, Sheikh HR, Simoncelli E.P. Image quality assessment: From error visibility to structural similarity. IEEE Transactions on Image Processing. 2004;13(4):600-612 https://doi.org/10.1109/TIP.2003.819861
  30. Nevriyanto A, Equalization AH. Enhancement, and Standard Median Filter (Noise Removal) with Pixel-Based and Human Visual System-Based Measurements. International Conference on Electrical Engineering and Computer Science. 2017;1(1): 114-119.
  31. Kugelman J, Alonso-Caneiro D, Read SA, Vincent SJ, Chen FK, Collins MJ. Effect of Altered OCT Image Quality on Deep Learning Boundary Segmentation. IEEE Access. 2020; 8:43537-43553. https://doi.org/10.1109/ACCESS.2020.2977355
  32. Kaur H, Rani J. MRI brain image enhancement using Histogram Equalization techniques. Proceedings of the 2016 IEEE International Conference on Wireless Communications, Signal Processing and Networking, WiSPNET 2016. 2016;1: 770-773.
  33. Srinivasan Y, Hernes D, Tulpule B, Yang S, Guo J, Mitra S, Yagneswaran S, Nutter B, Jeronimo J, Phillips B, Long R, Ferris D. A probabilistic approach to segmentation and classification of neoplasia in uterine cervix images using color and geometric features. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 2005;5747(2):995-1003.