Journal of Mushroom (한국버섯학회지)

The Korean Society of Mushroom Science (한국버섯학회)
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Optimization of submerged culture conditions for roridin E production from the poisonous mushroom Podostroma cornu-damae

  • Lee, Dong Hwan (Division of Environmental Forest Science and Institute of Agriculture & Life Science, Gyeongsang National University) ;
  • Ha, Si Young (Division of Environmental Forest Science and Institute of Agriculture & Life Science, Gyeongsang National University) ;
  • Jung, Ji Young (Division of Environmental Forest Science and Institute of Agriculture & Life Science, Gyeongsang National University) ;
  • Yang, Jae-Kyung (Division of Environmental Forest Science and Institute of Agriculture & Life Science, Gyeongsang National University)
  • Received : 2021.05.20
  • Accepted : 2021.06.24
  • Published : 2021.06.30
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Abstract

Roridin E, produced by Podostroma cornu-damae, is a mycotoxin with anticancer activity. To increase the content of roridin E, submerged culture conditions were optimized using response surface methodology. Three factors, namely, medium initial pH, incubation time and agitation speed were optimized using a Box-Behnken design. The optimum submerged culture conditions to increase the content of roridin E included a medium with an initial pH of 4.0, an incubation time of 12.90 days, and an agitation speed of 63.03 rpm. The roridin E content in the submerged culture, under the aforementioned conditions, was 40.26 mg/L. The findings of this study can help lower the current price of roridin E and promote its related research.

Keywords

Acknowledgement

This study was carried out with the support of R&D Program for Forest Science Technology (Project No. "2020253A00-2021-0001") provided by Korea Forest Service (Korea Forestry Promotion Institute).

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