Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Tissue Adequacy and Safety of Percutaneous Transthoracic Needle Biopsy for Molecular Analysis in Non-Small Cell Lung Cancer: A Systematic Review and Meta-analysis

  • Bo Da Nam (Department of Radiology, Soonchunhyang University College of Medicine, Soonchunhyang University Seoul Hospital) ;
  • Soon Ho Yoon (Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Hyunsook Hong (Medical Research Collaborating Center, Seoul National University Hospital) ;
  • Jung Hwa Hwang (Department of Radiology, Soonchunhyang University College of Medicine, Soonchunhyang University Seoul Hospital) ;
  • Jin Mo Goo (Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine) ;
  • Suyeon Park (Department of Biostatistics and Data Innovation, Soonchunhyang University Seoul Hospital)
  • Received : 2021.03.25
  • Accepted : 2021.06.07
  • Published : 2021.12.01
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Abstract

Objective: We conducted a systematic review and meta-analysis of the tissue adequacy and complication rates of percutaneous transthoracic needle biopsy (PTNB) for molecular analysis in patients with non-small cell lung cancer (NSCLC). Materials and Methods: We performed a literature search of the OVID-MEDLINE and Embase databases to identify original studies on the tissue adequacy and complication rates of PTNB for molecular analysis in patients with NSCLC published between January 2005 and January 2020. Inverse variance and random-effects models were used to evaluate and acquire meta-analytic estimates of the outcomes. To explore heterogeneity across the studies, univariable and multivariable metaregression analyses were performed. Results: A total of 21 studies with 2232 biopsies (initial biopsy, 8 studies; rebiopsy after therapy, 13 studies) were included. The pooled rates of tissue adequacy and complications were 89.3% (95% confidence interval [CI]: 85.6%-92.6%; I2 = 0.81) and 17.3% (95% CI: 12.1%-23.1%; I2 = 0.89), respectively. These rates were 93.5% and 22.2% for the initial biopsies and 86.2% and 16.8% for the rebiopsies, respectively. Severe complications, including pneumothorax requiring chest tube placement and massive hemoptysis, occurred in 0.7% of the cases (95% CI: 0%-2.2%; I2 = 0.67). Multivariable meta-regression analysis showed that the tissue adequacy rate was not significantly lower in studies on rebiopsies (p = 0.058). The complication rate was significantly higher in studies that preferentially included older adults (p = 0.001). Conclusion: PTNB demonstrated an average tissue adequacy rate of 89.3% for molecular analysis in patients with NSCLC, with a complication rate of 17.3%. PTNB is a generally safe and effective diagnostic procedure for obtaining tissue samples for molecular analysis in NSCLC. Rebiopsy may be performed actively with an acceptable risk of complications if clinically required.

Keywords

Acknowledgement

This work was supported by the Soonchunhyang University Research Fund.

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