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Mycobacterium genavense induced mycobacteriosis in an Indian peafowl (Pavo cristatus)

  • Oh, Yeonsu (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Lee, Sang-Joon (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Tark, Dong-Seob (Korea Zoonosis Research Institute, Jeonbuk National University) ;
  • Cho, Ho-Seong (College of Veterinary Medicine and Bio-Safety Research Institute, Jeonbuk National University)
  • Received : 2021.06.19
  • Accepted : 2021.06.26
  • Published : 2021.06.30

Abstract

The report describes an avian mycobacteriosis in a captive wild bird. A 7-year-old female Indian peafowl (Pavo cristatus) maintained in a zoo of Korea presented a gradual cachexia and eventually was found dead. At necropsy, severely atrophied pectoral muscles exposing the keel bone were noticed. Yellowish thick nodules in varying sizes were scattered in all lobes of lungs, liver and spleen, suggesting mycobacteriosis. Histopathologically, multifocal to coalescing granulomas surrounded by multinucleated giant cells were observed. Numbers of acid-fast bacilli were revealed in granulomas. Then, a series of molecular diagnostic techniques were followed: a nested PCR, DNA sequencing and bioinformatics analysis. It resulted as Mycobacterium genavense. The identification of M. genavense as an etiological agent suggested that it might serve as a risk factor for other captive wild animals, and for a potential zoonotic risk since M. genavense have been a definite cause of disseminated mycobacterial infection in immunocompromised people. To the authors' knowledge, this is the first report of avian mycobacteriosis with M. genavense in a captive Indian peafowl.

Keywords

Acknowledgement

This work was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) through Animal Disease Management Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA)(Project no. 320067-02-1-CG000).

References

  1. Bartos M, Hlozek P, Svastova P, Dvorska L, Bull T, Matlova L, Parmova I, Kuhn I, Stubbs J, Moravkova M, Kintr J, Beran V, Melicharek I, Ocepek M, Pavlik I. 2006. Identification of members of Mycobacterium avium species by ACCU-Probes, serotyping, and single IS900, IS901, IS1245 and IS901-flanking region PCR with internal standards. J Microbiol Methods 64: 333-345. https://doi.org/10.1016/j.mimet.2005.05.009
  2. Casaubon HMT, Brugere-Picoux J. 2015. Bacterial Diseases. pp. 360-363. In: Brugere-Picoux J, Vaillancourt JP, Bouzouaia M, Shivaprasad HL, Venne D(ed.). Manual of Poultry Diseases. Association Francaise Pour L'Avancement Des Sciences. Paris, France.
  3. Chevrier D, Oprisan G, Maresca A, Matsiota-Bernard P, Guesdon JL. 1999. Isolation of a specific DNA fragment and development of a PCR-based method for the detection of Mycobacterium genavense. FEMS Immunol Med Microbiol 23: 243-252. https://doi.org/10.1016/S0928-8244(98)00143-6
  4. Dvorska L, Bull TJ, Bartos M, Maltova L, Svastova P, Weston RT, Kintr J, Parmova I, Soolingen DV, Pavlik I. 2003. A standardized restriction fragment length polymorphism (RFLP) method for typing Mycobacterium avium isolates links IS901 with virulence for birds. J Microbiol Methods 55: 11-27. https://doi.org/10.1016/S0167-7012(03)00092-7
  5. Dvorska L, Matlova L, Ayele WY. Fischer OA, Amemori RT, Alvarez J, Beran V, Moravkova M, Pavlik I. 2007. Avian tuberculosis in naturally infected captive water birds of the Ardeideae and Threskiornithidae families studied by serotyping, IS901 RFLP typing, and virulence for poultry. Vet Microbiol 119: 366-374. https://doi.org/10.1016/j.vetmic.2006.09.010
  6. Forster F, Gerlach H, Kosters J. 1988. Mycobacteria in parrots and parakeets (Psittaciformes). Dt Tierarztl Wochenschr 95: 338-342.
  7. Friend M. 1999. Bacterial Diseases. pp. 93-98. In: Friend M, Franson JC(ed.). Field Manual of Wildlife Diseases, General Field Procedures and Diseases of Birds. USGS Biological Resources Division National Wildlife Health Center. Washington, DC, USA.
  8. Fulton RM, Sanchez S. 2018. Other Bacterial Diseases. pp. 1033-1043. In: Swayne DE, Boulianne M, Logue CM, McDougald LR, Nair V, Suarez DL(ed.). Diseases of Poultry. 14th ed. American Association of Avian Pathologists. Hoboken, NJ, USA.
  9. Fulton RM, Thoen CO, Saif YM, Barnes HJ, Glisson JR, Fadly FM, McDougald LR, Swayne DE. 2003. Other Bacterial Diseases. pp. 836-844. In: Diseases of Poultry. 11th ed.
  10. Godoy SN, Sakamoto SM, Paula CDD, Catao-Dias JL, Matushima ER. 2009. Detection of Mycobacterium avium in pet birds. Braz J Microbiol 40(2): 265-268. https://doi.org/10.1590/S1517-838220090002000011
  11. Gyimezi ZS, Stalis IH, Miller JM, Thoen CO. 1999. Detection of Mycobacterium avium subspecies avium in formalin-fixed, paraffin-embedded tissues of captive exotic birds using polymerase chain reaction. J Zoo Wildl Med 30: 348-353.
  12. Hoop RK, Bottger EC, Ossent P, Salfinger M. 1993. Mycobacteriosis due to Mycobacterium genavense in six pet birds. J Clin Microbiol 31: 990-993. https://doi.org/10.1128/jcm.31.4.990-993.1993
  13. Hughes MS, James G, Ball N, Scally M, Malik R, Wigney DI, Martin P, Chen S, Mitchell D, Love DN. 2000. Identification by 16S rRNA gene analyses of a potential novel mycobacterial species as an etiological agent of canine leproid granuloma syndrome. J Clin Microbiol 38: 953-9. https://doi.org/10.1128/JCM.38.3.953-959.2000
  14. Hwang ES, Lee TU, Jung DY, Cho HS. 2011. Development of loop-mediated isothermal amplification method for the rapid and sensitive detection of bovine tuberculosis in Korea native cattle. Korean J Vet Serv 34: 333-339. https://doi.org/10.7853/kjvs.2011.34.4.333
  15. Inglis NF, Stevenson K, Heaslip DG, Sharp JM. 2003. Characterisation of IS901 integration sites in the Mycobacterium avium genome. FEMS Microbiol Lett 221: 39-47. https://doi.org/10.1016/S0378-1097(03)00136-8
  16. Johansen TB, Olsen I, Jensen MR, Dahle UR, Holstad G, Djonne B. 2007. New probes used for ISI2450 and ISI311 restriction fragment length polymorphism of Mycobacterium avium subsp. avium and Mycobacterium avium subsp. hominissuis isolates of human and animal origin in Norway. BMC Microbiol 7: 14. https://doi.org/10.1186/1471-2180-7-14
  17. Jordan FTW, Hampson DJ. 2008. Some other bacterial diseases. pp. 250-254. In: Pattison M, McMullin PF, Bradbury JM, Alexander DJ(ed.). Poultry Diseases. 6th ed. Elsevier Limited: Philadelphia, PA, USA.
  18. Manarolla G, Liandris E, Pisoni G, Sassera D, Grilli G, Gallazzi D, Sironi G, Moroni P, Piccinini R, Rampin T. 2009. Avian mycobacteriosis in companion birds: 20-year survey. Vet Microbiol 133: 323-327. https://doi.org/10.1016/j.vetmic.2008.07.017
  19. Marco I, Domingo M, Lavin S. 2000. Mycobacterium infection in captive-reared capercaillie (Tetrao urogallus). Avian Dis 44: 227-230. https://doi.org/10.2307/1592531
  20. Montali RJ, Bush M, Thoen CO, Smith E. 1976. Tuberculosis in captive exotic birds. J Am Vet Med Assoc 169: 920-927.
  21. Moravkova M, Hlozek P, Beran V, Pavlik I, Preziuso S, Cuteri V, Bartos M. 2008. Strategy for the detection and differentiation of Mycobacterium avium species in isolates and heavily infected tissues. Res Vet Sci 85: 257-264. https://doi.org/10.1016/j.rvsc.2007.10.006
  22. Pai S, Esen N, Pan X, Musser JM. 1997. Routine rapid Mycobacterium species assignment based on species-specific allelic variation in the 65-kilodalton heat shock protein gene (hsp65). Arch Pathol Lab Med 121: 859-64.
  23. Palmieri C, Roy P, Dhillon, AS, Shivaprasad HL. 2013. Avian mycobacteriosis in psittacines: A retrospective study of 123 cases. J Comp Pathol 148: 126-138. https://doi.org/10.1016/j.jcpa.2012.06.005
  24. Sato Y, Aoyagi T, Matsuura S, Fukui S, Kitazawa I, Nishimori K, Yokomizo Y. 1996. An occurrence of avian tuberculosis in hooded merganser (Lophodytes cucullatus). Avian Dis 40: 941-944. https://doi.org/10.2307/1592322
  25. Schmitz A, Korbel R, Thiel S, Worle B, Gohl C, Rinder M. 2018. High prevalence of Mycobacterium genavense within flocks of pet birds. Vet Microbiol 218: 40-44. https://doi.org/10.1016/j.vetmic.2018.03.026
  26. Schrenzel MD. 2012. Molecular epidemiology of mycobacteriosis in wildlife and pet animals. pp. 1-23. In: M. D. Saggese(ed.). Mycobacteriosis, Veterinary Clinics of North America: Exotic Animal Practice. Philadelphia, USA.
  27. Shivaprasad HL, Dhillon AS. 2005. Mycobacteriosis in psittacine birds. Proc Assoc Avian Vet: 293-295.
  28. Shivaprasad HL, Palmieri C. 2012. Pathology of mycobacteriosis in birds. pp. 41-55. In: M. D. Saggese(ed.). Mycobacteriosis, Veterinary Clinics of North America: Exotic Animal Practice. Philadelphia, USA.
  29. Singbeil BA, Bickford AA, Stoltz JH. 1993. Isolation of Mycobacterium avium from ringneck pheasant (Phasianus colchicus). Avian Dis 37: 612-615. https://doi.org/10.2307/1591698
  30. Thoen CO, Karlson AG. 1991. Tuberculosis. pp. 172-185. In: Calnek BW, Barnes HJ, Beard CW, Reid WM, Yoder HW Jr(ed.). Diseases of Poultry. 9th ed. Iowa State University Press, Ames, Iowa 50010, USA.
  31. Tsiouris V, Kiskinis K, Mantzios T, Dovas CI, Mavromati N, Filiousis G, Brellou G, Vlemmas I, Georgopoulou I. 2021. Avian Mycobacteriosis and Molecular Identification of Mycobacterium avium Subsp. avium in Racing Pigeons (Columba livia domestica) in Greece. Animals 11: 291. https://doi.org/10.3390/ani11020291
  32. Zhai W, Wu F, Zhang Y, Fu Y, Liu Z. 2019. The immune escape mechanisms of Mycobacterium tuberculosis. Int J Mol Sci 20: 340. https://doi.org/10.3390/ijms20020340