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족관절 골절 환자의 골밀도 분석

Analysis of Bone Mineral Density of Ankle Fracture Patients

  • 김태형 (울산대학교 의과대학 서울아산병원 정형외과학교실) ;
  • 이재형 (울산대학교 의과대학 서울아산병원 정형외과학교실) ;
  • 박승환 (울산대학교 의과대학 울산대학교병원 정형외과학교실)
  • Kim, Tae Hyung (Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Jae Hyung (Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Park, Seung-Hwan (Department of Orthopedic Surgery, Ulsan University Hospital, University of Ulsan College of Medicine)
  • 투고 : 2020.11.27
  • 심사 : 2021.02.17
  • 발행 : 2021.08.30

초록

목적: 족관절 골절과 골다공증의 상관관계를 알아보기 위하여 족관절 골절 환자의 요추체와 대퇴골의 골밀도 값을 분석하였다. 대상 및 방법: 2002년 4월부터 2014년 7월까지 족관절 골절로 진단받고, 수상 후 1년 이내 골밀도 검사를 시행했던 100명의 환자를 분석하였다. 수상 당시 연령에 따라 50세 미만, 50세 이상 70세 미만, 70세 이상의 세 군으로 나누었고, 골절의 유형은 단과골절, 양과골절, 삼과골절로 분류하였다. 골밀도는 요추체(요추 1-4번 평균치), 대퇴골 경부, 대퇴골 전자부, 대퇴골 전체의 T점수, Z점수 및 골밀도 절대값(g/cm2)을 분석하였다. 결과: 족관절 골절 환자는 여자의 수가 남자보다 3.2배 많았다. 연령별 군에 따른 골다공증의 유병률은 50세 미만 군에서 0%, 50-69세 군에서 24.2%, 70세 이상 군에서 15%였고, 이중 50-69세 군에서 삼과골절 환자의 30%가 골다공증으로 나타났다. 전체 환자 군에서 연령이 낮을수록 단과 골절의 빈도가 높게 나타났다. 골밀도 값과 골절 유형과의 관계는 요추체의 T점수와 골밀도 절대값(g/cm2) 및 대퇴골 경부의 Z점수가 낮을수록 삼과 골절의 빈도가 증가하였으나, 이외의 다른 지표는 골절의 유형과 통계적으로 뚜렷한 상관관계를 보이지 않았다. 결론: 100명의 족관절 골절 환자를 분석한 결과, 여자의 수가 남자보다 많았으며 골다공증의 정도가 심하지 않을수록 삼과골절보다는 단과골절의 발생 빈도가 높은 경향을 보였지만, 족관절 골절과 대퇴골 및 요추의 골밀도 값과의 상관관계는 통계적으로 의미있게 나타나지 않았다.

Purpose: This study analyzed the bone mineral densities of the lumbar vertebrae and femurs of patients with ankle fractures to determine the correlation between ankle fractures and osteoporosis. Materials and Methods: From April 2002 to July 2014, one hundred consecutive ankle fracture patients with bone mineral density tests performed within post-traumatic one year were enrolled. The patients were divided into three age groups according to their age at the time of injury (group 1: <50, group 2: 50-69, group 3: ≥70). The types of ankle fractures were classified into unimalleolar, bimalleolar and trimalleolar fractures. The bone mineral density was analyzed using the T score, Z score, absolute value (g/cm2) of the lumbar spine (L1-L4), femur neck, femur intertrochanter, and total femur. Results: There were 3.2 times more females with ankle fractures than males, and the prevalence of osteoporosis according to age group was 0% in the group under 50 years, 24.2% in the 50 to 69-year-old group, and 15% in the group over 70 years. Osteoporosis was found in 30% of patients with a trimalleolar fracture in the 50 to 69-year-old group. In all patient groups, a lower age indicated a higher frequency of unimalleolar fractures. The relationship between the bone mineral density and the type of fracture is that the frequency of trimalleolar fracture increased with decreasing T score of the lumbar vertebrae and the absolute value of bone mineral density (g/cm2) and the Z score of the femur neck, but there were no other indicators. Conclusion: Among the 100 patients with ankle fractures, females were more common than males, because osteoporosis was less severe in males. The incidence of unimalleolar fracture was higher than that of trimalleolar fracture. On the other hand, the correlation between the ankle fractures and the bone mineral density of the femur and lumbar spine was not significant.

키워드

과제정보

This study was supported by a grant (2018IT0808) from the Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea.

참고문헌

  1. Yi H, Ha YC, Lee YK, Lim YT. National healthcare budget impact analysis of the treatment for osteoporosis and fractures in Korea. J Bone Metab. 2013;20:17-23. https://doi.org/10.11005/jbm.2013.20.1.17
  2. Cummings SR, Kelsey JL, Nevitt MC, O'Dowd KJ. Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev. 1985;7:178-208. https://doi.org/10.1093/oxfordjournals.epirev.a036281
  3. Jones G, Nguyen T, Sambrook PN, Kelly PJ, Gilbert C, Eisman JA. Symptomatic fracture incidence in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES). Osteoporos Int. 1994;4:277-82. https://doi.org/10.1007/BF01623352
  4. Hodkinson HM. Letter: osteomalacia and femoral fractures. Lancet. 1974;1:416. https://doi.org/10.1016/S0140-6736(74)93188-2
  5. Jahng JS, Moon SH. Measurement of bone mineral density in osteoporotic fracture of the spine using dual energy X-ray absorptiometry. J Korean Orthop Assoc. 1992;27:57-64. https://doi.org/10.4055/jkoa.1992.27.1.57
  6. Hasselman CT, Vogt MT, Stone KL, Cauley JA, Conti SF. Foot and ankle fractures in elderly white women. Incidence and risk factors. J Bone Joint Surg Am. 2003;85:820-4. https://doi.org/10.2106/00004623-200305000-00008
  7. Lee KM, Chung CY, Kwon SS, et al. Ankle fractures have features of an osteoporotic fracture. Osteoporos Int. 2013;24:2819-25. https://doi.org/10.1007/s00198-013-2394-6
  8. Therdyothin A, Phiphopthatsanee N, Wajanavisit W, Woratanarat P, Laohajaroensombat S, Tawonsawatruk T. Is ankle fracture related to low bone mineral density and subsequent fracture? A systematic review. Osteoporos Sarcopenia. 2020;6:151-9. https://doi.org/10.1016/j.afos.2020.08.003
  9. Bauer M, Bengner U, Johnell O, Redlund-Johnell I. Supination-eversion fractures of the ankle joint: changes in incidence over 30 years. Foot Ankle. 1987;8:26-8. https://doi.org/10.1177/107110078700800107
  10. Bengner U, Johnell O, Redlund-Johnell I. Epidemiology of ankle fracture 1950 and 1980. Increasing incidence in elderly women. Acta Orthop Scand. 1986;57:35-7. https://doi.org/10.3109/17453678608993211
  11. Patterson J, Rungprai C, Den Hartog T, et al. Cortical bone thickness of the distal part of the tibia predicts bone mineral density. J Bone Joint Surg Am. 2016;98:751-60. https://doi.org/10.2106/JBJS.15.00795
  12. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA. 2001;285:785-95. https://doi.org/10.1001/jama.285.6.785
  13. Compston JE, Cooper C, Kanis JA. Bone densitometry in clinical practice. BMJ. 1995;310:1507-10. https://doi.org/10.1136/bmj.310.6993.1507
  14. Moon SH, Kong GM, Suh BH, Cho HG. Comparison of bone mineral density in elderly patients according to presence of intertrochanteric fracture. J Clin Densitom. 2008;11:450.
  15. Cameron JR, Sorenson J. Measurement of bone mineral in vivo: an improved method. Science. 1963;142:230-2. https://doi.org/10.1126/science.142.3589.230
  16. Lee KH, Moon CW, Kim YS, Kim HM, Jung SL. Clinical comparison of ankle fractures between the young and the elderly. J Korean Foot Ankle Soc. 2005;9:105-9.
  17. Jung HG, Park HK, Yoo MJ, Kim TW. The evaluation of clinical and radiographic prognostic factors for the surgically treated unstable ankle fractures. J Korean Fract Soc. 2002;15:216-25. https://doi.org/10.12671/jksf.2002.15.2.216
  18. Rao YS, Ahmed S, Vardan KV, Ahmed KA, Gopal RR. Prospective study of ankle and foot fractures in elderly women. J Med Allied Sci. 2015;5:2-5.
  19. Seeley DG, Kelsey J, Jergas M, Nevitt MC. Predictors of ankle and foot fractures in older women. The Study of Osteoporotic Fractures Research Group. J Bone Miner Res. 1996;11:1347-55. https://doi.org/10.1002/jbmr.5650110920
  20. Lee DO, Kim JH, Yoo BC, Yoo JH. Is osteoporosis a risk factor for ankle fracture?: comparison of bone mineral density between ankle fracture and control groups. Osteoporos Sarcopenia. 2017;3:192-4. https://doi.org/10.1016/j.afos.2017.11.005
  21. Lee J, Lee S, Jang S, Ryu OH. Age-related changes in the prevalence of osteoporosis according to gender and skeletal site: the Korea National Health and Nutrition Examination Survey 2008-2010. Endocrinol Metab (Seoul). 2013;28:180-91. https://doi.org/10.3803/EnM.2013.28.3.180
  22. Lee YK, Jang S, Ha YC. Management of osteoporosis in South Korea. Crit Rev Eukaryot Gene Expr. 2015;25:33-40. https://doi.org/10.1615/CritRevEukaryotGeneExpr.2015012425