Journal of Genetic Medicine

  • 제18권1호
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  • Pages.1-7
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  • 2021
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  • 1226-1769(pISSN)
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  • 2383-8442(eISSN)
대한의학유전학회 (Korean Society of Medical Genetics and Genomics)
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Cumulus and granulosa cell biomarkers: a good predictor for successful oocyte and embryo developmental competence in human in vitro fertilization

  • Yu, Eun Jeong (Department of Obstetrics and Gynecology, CHA Fertility Center Seoul Station, CHA University School of Medicine) ;
  • Lyu, Sang Woo (Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University School of Medicine)
  • 투고 : 2021.05.24
  • 심사 : 2021.06.15
  • 발행 : 2021.06.30
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초록

The oocyte quality is of great importance in infertility as it reflects the follicle developmental potential and further affects the embryo development, clinical pregnancy outcomes. The analysis of gene expression in somatic cells is an important study to better clinical in vitro fertilization (IVF) outcomes in embryo selection reflecting the appropriate communication between the oocyte and somatic cells. Specifically, somatic cell transcriptomic technology can help assess biomarkers of oocyte and embryo ability. The present article aims to overview the basic aspect of folliculogenesis and review studies involving changes in candidate gene expression of cumulus or granulosa cell related to clinical outcomes in human IVF.

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참고문헌

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